EricMM
Well-known member
Guys,
I am one of the formulators for LG Sciences and I wanted to explain the products. Each one of the prohormones has 50mg minimum of Epicatechin (EC) and this is a great addition to the LG Sciences DHEA prohormones. Each prohormone uses the Liposomal delivery technology which helps bypass liver metabolism and clearance while the EC increases 17bHSD activity in the testes and likely in the entire body:
"EC, one of the catechins increased the testosterone secretion by rat LCs via the enzyme activities of 17β-hydroxysteroid dehydrogenase (17β-HSD)"
This means increased conversion, increased activity and better utilization than prohormone formulations that use more active. Pouring more active into a supplement without the addition of cofactors vastly reduces the conversion rate!
Just thought you would like to know why LG is worth the money compared to other prohormones! This is one study but for an ingredient that inhibits myostatin and increases conversion, you can't beat LG prohormones with this amazing ingredient!
Invalid Link Removed
†Shyi-Wu Wang and Paulus S. Wang contributed equally.
Abstract
Catechins have been reported to have many pharmacological properties such as the effects of anti-oxidative, anti-inflammatory, anti-carcinogenic, anti-ultraviolet, and reduction of blood pressure as well as glucose and cholesterol levels. However, the effect of catechins on the reproductive mechanism is still unknown. In the present study, the effects of catechins on testosterone secretion in rat testicular Leydig cells (LCs) were explored. Both in vivo and in vitro investigations were performed. Purified LCs were incubated with or without catechin (CCN), epicatechin (EC), epigallocatechin gallate (EGCG, 10−10–10−8 M) under challenge with human chorionic gonadotropin (hCG, 0.01 IU/ml), forskolin, SQ22536 (an adenylyl cyclase inhibitor), 8-bromo-adenosine 3′:5′-cyclic monophosphate (8-Br-cAMP), A23187 (a calcium ionophore), and nifedipine (10−5 M), respectively. To study the effects of catechins on steroidogenesis, steroidogenic precursors-stimulated testosterone release was examined. The functions of the steroidogenic enzymes including protein expression of cytochrome P450 side chain cleavage enzyme (P450scc) and steroidogenic acute regulatory (StAR) protein were investigated and expressed by Western blotting. Catechins increased plasma testosterone in vivo in male rats. In vitro, low-dose concentration of catechins increased gonadotropin releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release by anterior pituitary gland and hCG-stimulated testosterone release by LCs of male rats. These results suggested that catechins stimulated testosterone production by acting on rat LCs via the mechanism of increasing the action of cAMP, but not P450scc, StAR protein or the activity of intracellular calcium. EC, one of the catechins increased the testosterone secretion by rat LCs via the enzyme activities of 17β-hydroxysteroid dehydrogenase (17β-HSD). J. Cell. Biochem. 110: 333–342, 2010. © 2010 Wiley-Liss, Inc.
I am one of the formulators for LG Sciences and I wanted to explain the products. Each one of the prohormones has 50mg minimum of Epicatechin (EC) and this is a great addition to the LG Sciences DHEA prohormones. Each prohormone uses the Liposomal delivery technology which helps bypass liver metabolism and clearance while the EC increases 17bHSD activity in the testes and likely in the entire body:
"EC, one of the catechins increased the testosterone secretion by rat LCs via the enzyme activities of 17β-hydroxysteroid dehydrogenase (17β-HSD)"
This means increased conversion, increased activity and better utilization than prohormone formulations that use more active. Pouring more active into a supplement without the addition of cofactors vastly reduces the conversion rate!
Just thought you would like to know why LG is worth the money compared to other prohormones! This is one study but for an ingredient that inhibits myostatin and increases conversion, you can't beat LG prohormones with this amazing ingredient!
Invalid Link Removed
†Shyi-Wu Wang and Paulus S. Wang contributed equally.
Abstract
Catechins have been reported to have many pharmacological properties such as the effects of anti-oxidative, anti-inflammatory, anti-carcinogenic, anti-ultraviolet, and reduction of blood pressure as well as glucose and cholesterol levels. However, the effect of catechins on the reproductive mechanism is still unknown. In the present study, the effects of catechins on testosterone secretion in rat testicular Leydig cells (LCs) were explored. Both in vivo and in vitro investigations were performed. Purified LCs were incubated with or without catechin (CCN), epicatechin (EC), epigallocatechin gallate (EGCG, 10−10–10−8 M) under challenge with human chorionic gonadotropin (hCG, 0.01 IU/ml), forskolin, SQ22536 (an adenylyl cyclase inhibitor), 8-bromo-adenosine 3′:5′-cyclic monophosphate (8-Br-cAMP), A23187 (a calcium ionophore), and nifedipine (10−5 M), respectively. To study the effects of catechins on steroidogenesis, steroidogenic precursors-stimulated testosterone release was examined. The functions of the steroidogenic enzymes including protein expression of cytochrome P450 side chain cleavage enzyme (P450scc) and steroidogenic acute regulatory (StAR) protein were investigated and expressed by Western blotting. Catechins increased plasma testosterone in vivo in male rats. In vitro, low-dose concentration of catechins increased gonadotropin releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release by anterior pituitary gland and hCG-stimulated testosterone release by LCs of male rats. These results suggested that catechins stimulated testosterone production by acting on rat LCs via the mechanism of increasing the action of cAMP, but not P450scc, StAR protein or the activity of intracellular calcium. EC, one of the catechins increased the testosterone secretion by rat LCs via the enzyme activities of 17β-hydroxysteroid dehydrogenase (17β-HSD). J. Cell. Biochem. 110: 333–342, 2010. © 2010 Wiley-Liss, Inc.
