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When the boss is away.......(CONTEST)

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joecski said:
I took taurine pre-workout with citrulline malate. Nice non-stim energy boost.
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Just i've heard a few guys using it to get rid of back pumps when used with some of the designer hormones, and i'd rather have the pump during workout, and loose it after
 
I was only able to scarf down 40g of protein (Chocolate Mint shake) with a scoop of Cycle Support (Chocolate Peanut Butter) and a yogurt parfait
 
IGF-2 (240 caps/700 mg)

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Immediate Growth Factor
Applied Nutriceuticals Research is proud to introduce the newest and most effective anabolic product on the market, IGF-2™. IGF-2™ is a powerful blend of the strongest legally available herbal compounds, perfectly standardized to provide the highest quality and effectiveness. IGF-2™ incorporates Safed Musli, Mucuna Pruriens, Dodder Seed, and Rhodiola Rosea combined into a specific, synergistic formula that produces amazing results faster than would ever be expected from an over-the-counter preparation.

Safed Musli is an Ayurvedic herb used for centuries to improve physical strength and male fertility. We now know that this due to the high concentrations of spirosta-steroidal saponins found in this compound, which have been shown to significantly increase testosterone levels (1,2,3,6). Mucuna Pruriens, another Ayurvedic herb, contains high concentrations of L-Dopa, a compound responsible for increasing endogenous GH and testosterone secretion (15). Dodder Seed (Cuscuta Chineses) is an herb used by the Chinese for centuries to treat male impotence and infertility, which has been shown to increase cAMP production (cyclic AMP – a precursor to ATP, the primary cellular energy molecule), as well as testosterone levels (26). Rhodiola Rosea is an adaptogenic herb that has been shown in animal studies to boost ATP, glycogen, and Creatine Phosphate levels, and has been shown in humans to decrease physiological stress while increasing memory, alertness, and energy (23,24,25).

Product Overview: IGF-2 and Hormonal Systems
The compounds contained in IGF-2™ stimulate a variety of complex reactions and messenger systems in the body, most notably through direct gene activation and the second messenger system. Safed Musli, Mucuna Pruriens, and Dodder Seed all have been shown to increase testosterone production in the body via a number of different mechanisms (1,2,26,27).

Testosterone Production
Safed Musli, in particular, contains large amounts of Spirosta-steroidal saponins: desoxydiosgenin, tigogenin, neotigogenin, which are intermediates to various hormonal pathways in the body (1,2). When ingested, desoxydiosgenin from Safed Musli is enzymatically converted to 11-oxa-5 alpha-androstane-3,17-dione, some of which is converted to testosterone through the testes. The increased testosterone produced by this process binds to the androgen receptor (AR), signaling the muscles via mRNA to increase protein synthesis and nitrogen retention, leading to greater strength, mass, and recovery (1,2,27).
Testosterone, which is lipid soluble, diffuses through the cell wall, binding to the intracellular androgen receptor (AR). The binding causes an activation of the hormone receptor, and the activated receptor complex continues on to the nucleus of the cell, where the hormone binds to a DNA receptor protein. This signals the transcription of DNA to produce mRNA(3). The mRNA is then transplanted to the ribosomes of the cell, signaling the body to increase protein synthesis in a variety of target tissues (skeletal muscle) (3).

L-Dopa and its effects on Testosterone and Human Growth Hormone
Another important chemical mechanism of IGF-2™ is L-Dopa-induced growth hormone (GH) release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can suppress the secretion of gonadotropins, which hinders testosterone production. By inhibiting prolactin, IGF-2 increases endogenous testosterone levels dramatically. The variety of Mucuna Pruriens used in IGF-2™ is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule (27). L-Dopa is a precursor to Dopamine, a powerful biogenic amine, and L-Dopa is the only method of transport of Dopamine through the blood-barrier(3,15,16). Dopamine is a potent GH and testosterone agonist, meaning that dopamine inhibits prolactin release and hypothalamic somatostatin secretion, which allows for a greater stimulatory effect of growth hormone-releasing hormone (GHRH) and secretion of testosterone by the testes. GHRH signals the pituitary to release GH, a polypeptide hormone produced by the somatotropic cells of the anterior pituitary (3,11,12,14,15,16). GH stimulates skeletal muscle cells to grow and, in some cases, divide. Acting directly, GH mobilizes fats from fat depots and decreases the rate of glucose intake and metabolism. In mammals, GH exerts most of its anabolic effects through being mediated by IGF; IGF is also known as somatomedin, which stimulates the uptake of amino acids from the blood and into skeletal muscle, providing for a variety of anabolic effects in the human body. This is important, as IGF-2™ provides the biochemical stimulus for the aforementioned muscle-building processes.

Dodder Seed, Rhodiola Rosea
Dodder Seed is another important component of IGF-2™ as it also activates the second messenger system, and subsequently causes adenylate cyclase to generate cAMP from ATP (3,26). cAMP generation has a variety of effects on tissue and glandular activity, but the most notable is the stimulation of the thyroid to produce thyroxin (promoting elevated fat burning). Increased cAMP levels to also activate the protein kinase enzyme, which in turn activates hormone-sensitive lipase (HSL) in targeted tissues(10,11,13) and signals for the production of luteinizing hormone, which elevates testosterone levels in males. Elevations in these two hormones can cause a marked increase in fat as body fuel, as well as a strong correlation to decreased body fat and increased muscle mass, density and strength.

Rhodiola Rosea also displays some individualistic qualities of greater ATP enhancement and creatine phosphate storage in animal studies. At the Tomsk State University and Medical Institute in Russia, mice were administered Rhodiola supplementation and made to swim to exhaustion twice a day for six days. At the end of the testing period, muscle biopsies were performed, with the Rhodiola-treated mice having 17% greater ATP levels 45% greater creatine phosphate stores, and 53% greater muscle glycogen levels, while having lower intramuscular concentrations of lactic acid and ammonia (23,24,25). The rosavin and salidroside content of Rhodiola Rosea has also been shown to have significant effects on stress reduction in human studies by reducing cortisol release, while optimizing levels of key brain chemicals such as serotonin and dopamine that function together to maintain a healthy response to stress (20-25). Blocking cortisol is a very important effect, as cortisol breaks down muscle tissue and increases body fat, slowing the metabolism and lowering immune function. Rhodiola has been shown to also have adaptogenic qualities, allowing the human body to work harder during stress, while at the same time maintaining higher energy reserves (20-25). This is important to hard-training athletes because intense stress and strain can cause significant increases in stress hormone levels like cortisol (20-25), thus diminishing results.

Synergy
The ingredients in IGF-2™, precisely blended to optimal ratios together produce a powerful synergistic combination. Synergism of hormones occurs in situations where more than one hormone produces the same effects at the target cell, and their combined effects are amplified. Safed Musli contains large amounts of the spirosta-steroidal saponins and Mucuna Pruriens, as mentioned before, converts to L-Dopa. L-Dopa converts to dopamine, which increases testosterone (via prolactin inhibition) and growth hormone through an increase in GHRH release (1,10,11,12,16,17,18,27). GH converts to IGF-1, and exerts anabolic effects in skeletal muscle. Also, and even more importantly, hormonal compounds (like desoxydiosgenin) can increase IGF-1 in muscle tissue as well, and maybe even aid in the ability of the skeletal muscles to use GH and IGF. Increased testosterone also tells the body to continue producing GH endogenously, stopping the negative feedback loop (10-12). In conclusion, IGF-2™ employs powerful inter-compound synergism, leading to more rapid muscular growth, along with increased recovery and noticeable strength increases.

1. Salvi VS, Mukhurjee D, Engel CR (1986). Steroids and related products LIV. The synthesis of 11-oxa steroids VI. The Synthesis of
11-oxatestosterone. Steroids 48(1-2):47-53.
2. Johns W (1970) The 12a,13b-Etiojervance Analog of Testosterone. J. Org. Chem. 36(5): 711-19.
3. Marieb, E. Human Anatomy and Physiology, 6th Edition. (2004). Pearson Benjamin Cummings, San Francisco.
4. Singh R, Artaza WE, Taylor WE (2005) Testosterone inhibits adipogenic differentiation in 3t3-L1 cells: nuclear translocation of androgen
rec. complex w/ catenin. Endocrinology 16210377.
5. Hikim, Bashim, Taylor (2004) Androgen Receptor in Human Skeletal Muscle and Cultured Muscle Cells: Up regulation by androgen
treatment. The J. of Clin. Endo. And Metab. 89: 5245-5255.
6. Kaushik, N (2005) Saponins of Chlorophytum Species. Phytochemistry Reviews. 4(2-3): 191-196.
7. Rath, S (2003) Botanical source of safed musli. Sachitra Ayurved. 55(11): 866-869.
8. Deepak and Bhatnagar (2004) Pharmacognostical evaluation of Chlorophytum borivillanum root, Ancient Science of Life. 24(1): 30-37.
9. Richelsen B (1999) Effect of growth hormone on adipose tissue and skeletal muscle lipoprotein lipase activity in humans. J Endocronol
Invest. 22(5):10-15.
10. Dimaraka EV, Jaffe CA, Bowers CY, Marbach P (2003) Pulsatile and nocturnal growth hormone secretions in men do not require
periodic declines of somatostatin. Am J Phsiol Endocrinol Metab. 285(1): 163-170.
11. Jensen MD (2003) Effects of growth hormone administration on human obesity. Obes. Res. 11(2). 170-5.
12. The thyroid gland. Endocrinology: An Integrated Approach by Stephen Nussey and Saffron Whitehead (2001). Published by BIOS
Scientific Publishers Inc.
13. Eggo MC, Bachrach LK, Burrow GN. (1990) Interaction of TSH, insulin and insulin-like growth factors with thyroid growth and function.
Growth Factors. 2(2-3). 99-109.
14. Rathi SS, Grover JK, Vats V. (1999) The effect of momordica charantia and Mucuna pruriens in experimental diabetes and their effect
on key metabolic enzymes involved in carbohydrate metabolism. Department of Pharmacology, All India Institute of Medical Sciences,
Ansari Nagar, New Delhi.
15. Parikh et al, (1990) Indian Drugs. Chem Abs 27: 353. \
16. Ahmad S et al (1991) Conference of Pharmacology and Simposium on Herbal Drugs (New Delhi), March 1991, 15:26.
17. Manyam BV (1995) J. Altern. Completment Med. Fall. 1(3) 244-255.
18. Takahashi Y, Kipnis M, Daughaday WH (1968) Growth hormone secretion during sleep. J Clin Invest 47(9): 2079-2090.
 
Lipotrophin-AM (120 capsules/600 mg)

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Applied Nutriceuticals has developed a powerful new fat burning compound through extensive research and application of the most modern scientific principles. Our research team invested the last year and a half in product development and testing, filtering through the countless ingredients available on the market in order to find the most effective product possible. The team finally concluded that the active ingredients in this formula, when specially titrated and synergistically proportioned to optimized dosage levels, creates the most effective fat metabolizer available today without a prescription. The result is Lipotrophin AM™.

Lipotrophin-AM contains methylxanthine anhydrous caffeine (MXAC), a xanthine alkaloid compound that acts as a metabolic stimulant that has been used by humans since the Stone Age (1,2,3). Additionally, it incorporates Green Tea, a compound used in China for thousands of years to promote health in the mind and body. Green Tea has strong anti-oxidant properties, and its main ingredient, EGCG, has been shown to have significant metabolic benefits (5). Lipotrophin AM also contains Bacopa Monnieri, an Ayurvedic herb that boosts thyroid function and conversion, which is a potent fat-burning stimulus and also been shown to reduce stress levels (22). Mucuna Pruriens, the final ingredient in Lipotrophin-AM, contains large amounts of L-Dopa, a potent compound that allows for greater growth hormone release (13). The combination of the ingredients in Lipotrophin-AM are specially titrated into a powerful synergistic compound, designed to turn your body into a fat-burning machine!

Energy Metabolism, Caffeine, and Green Tea
Methylxanthine anhydrous caffeine (MXAC) is a central nervous system and metabolic stimulant that temporarily restores alertness and reduces physical fatigue. It also improves general body coordination and exerts many beneficial effects on the body, such as fat loss and.energy metabolism. Methylxanthine anhydrous caffeine has been shown to increase lipolysis (fat burning), by liberating glycerol and free fatty acids from triglycerides (stored fat). This is important because when free fatty acids and glycerol enter the blood stream they can be readily disposed of as energy. MXAC accomplishes lipolysis through a multifaceted system, starting with an increase in norepinephrine (NE), a neurotransmitter responsible for alertness and also for fat loss. Once NE is activated, it allows cAMP (cyclic AMP, an energy molecule necessary for fat liberation) to build up in cells. NE begins this process of cAMP build-up by combining with beta receptors on a target cell to stimulate cAMP-phosphodiesterase (PDE), an enzyme that allows cAMP levels to increase in cells. Increased levels of cAMP within the cell ultimately result in greater amounts of fatty acids being liberated from triglycerides through the following mechanism: Increased cAMP levels cause the protein kinase enzyme PKA to activate production Hormone-Sensitive Lipase (HSL), a hormone responsible for fat loss. HSL then triggers the release of fatty acids from triglycerides (fat tissue). These resulting fatty acid chains are broken down within the fat cell, which are subsequently broken down even further into acetyl-CoA. Acetyl-CoA is an important energy substrate that is in a form that can be readily utilized during the Krebs Cycle, which is active during aerobic exercise. This is am primary mechanism of how fat is disbursed as fuel for the body, but is just one of the many ways that Lipotrophin-AM facilitates fat metabolization (1,2,3). Green Tea is a versatile herb used for many centuries for a variety of maladies. Recent studies have determined Green Tea to be a strong fat burner that works through several different complementary mechanisms. It is composed mainly of catechins, pheophytins, chlorophylls, carotenoids, theanine, and a small amount of caffeine (1,2,4,5). EGCG, a catechin found in high amounts in Lipotrophin, is the most relevant compound, because in exerts a variety of important metabolic, nutrient partitioning, and appetite-controlling effects that contribute to significant weight loss. Green tea is a potent appetite suppressant, as the EGCG triggers the brain to secrete higher amounts of cholecystokinin (CCK), a peptide hormone that is vital in control of the appetite and the digestion of fat and protein (3,7). Green Tea also seems to have a nutrient-repartitioning quality, which means it has the ability to allow for the metabolism and utilization of macronutrients (carbohydrates and bound triglycerides as fuel), while disallowing others (like dietary fat) to be digested and stored. This nutrient-repartitioning quality is extremely important during weight and body fat loss, as EGCG allows the body to preferentially utilize fat as fuel over carbohydrates. Clinical studies on human subjects have confirmed this, showing that increases of preferential fatty acid oxidation over glucose have been noted in the majority of subjects while taking Green Tea. Another important piece of this puzzle has to do with the fact that the EGCG in Green Tea has been shown to inhibit the production of catechol-0-methyl-transferase (COMT). COMT is important to fat loss, because it is the enzyme that breaks down norepinephrine; therefore limiting the production of COMT allows norepinephrine to exert much stronger effects on the fat-burning cascade (4,6,7).

Mucuna Pruriens and Bacopa Monnieri
Another important mechanism of action in the Lipotrophin-AM fat loss arsenal is the release of L-Dopa-induced growth hormone (GH) and L-Dopa-related control of carbohydrate cravings and blood sugar (8,10,11,12). The mucuna pruriens contained in Lipotrophin-AM is of the highest quality, and is standardized to 25% L-Dopa. There is plentiful documentation of L-Dopa’s potent neurotransmitter-boosting effects, including its conversion to dopamine and its blood sugar controlling effects, both of which are very noteworthy for weight loss. Low neurotransmitter levels (mainly dopamine and serotonin) can result in cravings for sugars and sweets and depression, to which to most common response is “comfort eating”. Obviously, uncontrolled cravings can wreck any diet or weight loss plan. Mucuna helps stem this problem due to its properties that attenuate blood sugar levels, which is important because high blood sugar triggers higher insulin secretion and which results in high insulin levels. The inclusion of mucuna pruriens allows for a greater control of cravings and glucose utilization, benefiting the user by allowing for greater weight loss.

While mucuna limits blood sugar and controls cravings, it positively effects GH levels as well. As mentioned earlier, Lipotrophin-AM contains large amounts of L-Dopa, and L-Dopa is the only form of Dopamine that can cross the blood/brain barrier. Once L-Dopa is converted to Dopamine in the brain, it allows for a greater stimulation of GHRH (growth hormone releasing hormone), which directly stimulates increased growth hormone production. Acting directly, GH mobilizes fats from fat depots and decreases the rate of glucose intake and metabolism, and higher dopamine levels allow for control of cravings. Growth Hormone mobilizes fats through the regulation of HSL (Hormone Sensitive Lipase), which we have discussed earlier (8,13,14,15,16). This is extremely important part of the fat loss equation, as the more HSL released to liberate fatty acids that can be burned as fuel, the more significant your fat loss will be.

Bacopa Monnieri is the final ingredient in Lipotrophin. Studies have shown that Bacopa can increase T4 (thyroxine, a thyroid hormone) synthesis by up to 41% in mice, while allowing the uninterrupted conversion of T4 to T3. This is noteworthy, because thyroid hormone is metabolically active, and is an important component of fat loss. Conversion of T4 to T3 is an important aspect of this process, and is affected by increased levels of GH, which occurs during the usage of Lipotrophin-PM. T4 is synthesized from free tyrosine, and combined with iodine, and upon stimulation by TSH (Thyroid Stimulating Hormone), T3 and T4 are formed ((18,25). Thyroid hormone produced is about 90% T4 and 10% T3, and T3 is considered the biologically active component of thyroid, as T4 must be converted down to T3 for it to be active in target tissues (12). The production of thyroxine is regulated by TSH, and TSH is suppressed when T4 levels are high. GH decreases T4 levels due to heightened conversion to T3, and when T4 levels become too low, thyroid function becomes altered. The mechanism of action of Bacopa is crucial to this process, as it stimulates the continued synthesis of T4, providing a constant and readily available source of convertible material that will ultimately become T3 (25). This is extremely important to fat loss, because T3 is roughly ten times more biologically active than T4, and T3 increases basal metabolic rate and body heat production, resulting in greater fat loss.

In summary, our exhaustive research into fat metabolization has produced the creation of an effective, powerful new fat burning formulation that outperforms the big brands, providing you with a wide range of benefits from reducing physical fatigue and restoring mental alertness to dramatic increases in fat metabolism, even while at rest, allowing your body to use fat as fuel.

1. Nehlig A, Daval JL, Debry, G (1992). Caffeine and the CNS: Mechanisms of Action, biochemical, metabolic, and psychostimulant effects. Brain Res Rev 17(2): 139-170.
2. Weinberg BA, Belar BK (2001). The World of Caffeine. Routledge. ISBN 0-415-92722-6.
3. Bolton PHd. Sanford GN (1981). Caffeine: Psychological Effects, Use and Abuse. Orthomolecular Psychiatry 10(3): 202-211.
4. Nagua T, Komine Y, Soga S, Meguro S, Hase T, Tanaka Y, Tokimitsu I (2004). Anti-obesity actions of green tea: possible involvements in modulation of the glucose uptake system and suppression of the adipogenesis-related transcription factors. Biofactors 22(1-4): 135-140.
5. Carlson A (2005). Ingestion of a tea rich in catchechins leads to a reduction in body fat and malondialhyde-modified LDL in men. Am J Clin Nutri 81(1): 122-129.
6. Greenough A, Cole G, Lewis J, Lockton A, Blundell J (1998). Untangling the effects of hunger, anxiety, and nausea on energy intake during IV cholecystokinin octapeptide (CCK-8) infusion. Physiol Behav 65(2): 303-310.
7. Fink A, Rex A, Voits M, Voight JP (1999). Major biological actions of CCK- a critical evaluation of research findings. Exp Brain Res 123(1-2): 77-83.
8. Chantre P, Lairon D (2002). Phytomedicine. Recent findings of green tea extract AR 25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 9(1): 3-8.
9. Dulloo AG, Seydoux J Girardier L, Chantre P (2000). Green tea and thermogenesis: Interactions between catechin-polyphenols, caffeine, and sympathetic activity. Int J Obes Relat Metab Dis 24 (2): 252-258.
10. Kao YH, Hilpakka RA, Liao S (2000) Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 141(3): 980-7.
11. Richelsen B (1999) Effect of growth hormone on adipose tissue and skeletal muscle lipoprotein lipase activity in humans. J Endocronol Invest. 22(5):10-15.
12. Dimaraka EV, Jaffe CA, Bowers CY, Marbach P (2003) Pulsatile and nocturnal growth hormone secretions in men do not require periodic declines of somatostatin. Am J Phsiol Endocrinol Metab. 285(1): 163-170.
13. Jensen MD (2003) Effects of growth hormone administration on human obesity. Obes. Res. 11(2). 170-5.
14. The thyroid gland. Endocrinology: An Integrated Approach by Stephen Nussey and Saffron Whitehead (2001). Published by BIOS Scientific Publishers Inc.
15. Eggo MC, Bachrach LK, Burrow GN. (1990) Interaction of TSH, insulin and insulin-like growth factors with thyroid growth and function. Growth Factors. 2(2-3). 99-109.
16. Rathi SS, Grover JK, Vats V. (1999) The effect of momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
17. Parikh et al, (1990) Indian Drugs. Chem Abs 27: 353. \
18. Ahmad S et al (1991) Conference of Pharmacology and Simposium on Herbal Drugs (New Delhi), March 1991, 15:26.
19. Manyam BV (1995) J. Altern. Completment Med. Fall. 1(3) 244-255.
20. Takahashi Y, Kipnis M, Daughaday WH (1968) Growth hormone secretion during sleep. J Clin Invest 47(9): 2079-2090.
21. Kar A, Panda S, Bharti S (2002) Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol 81(2): 281-85.
22. Rai D, Bhatia P, Palit G, Pal R, Singh S, Singh HK (2003) Adaptogenic effect of Bacopa Monnieri. Pharmacol Biochem. Behavior 75(4): 823-830.
 
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