2kvette You definitely should be proud of your education and being considered an expert in this area. I just I wish you would have spent those words educating me on WHY I was wrong instead of telling me why you are sure that I am wrong... I would prefer to learn than just be told I am wrong.
I am going to take a few guesses and explain my thoughts on some of the things you mentioned I had wrong. Maybe you can tell me a little more as to why I would be wrong on them so I can learn from this.
1. DHT has a very high binding affinity to the AR especially in breast tissue it is up to 3 times more likely to bind to the AR than estrogen. When in higher amounts it will typically bind to the breast tissue, take up the space that estrogen would, causing less estrogen binding so less estrogenic activity at the breast tissue level. Is this not correct? It is why I said that DHT can help avoid gyno from trest. Yes, I also understand that a lot of the gyno from 19-nors is prolactin related as well, and I did not address that in my post but probably should have. Depending on dose I would recommend a supplement or compound that reduced prolactin as well to avoid gyno. At least have something on hand anyway...
From reading a little on intrinsic activity it is how effectively the Receptors can produce a response to the agonist, as opposed to affinity which is the likelihood of the agonist binding to the Receptor. I was only speaking to the affinity from this explanation.
Do you mind telling me the difference between binding affinity and intrinsic activity in your own words, and what that has to do with how DHT taking up a space on the breast tissue AR keeping estrogen from binding to it and expressing itself. Reason being I am only considering DHT as an estrogen blocker in this scenario, if it binds then estrogen can not, therefore the estrogen can not act on it. This is what I have learned inmy research and stiudies anyway, is this not correct?
Anyway, not trying to be a D1ck back, I would just rather be corrected than simply told I am wrong. Nothing can be corrected without learning why I was wrong. Help a brother out if you don't mind. I definitely don't have your education but love to learn.