What is the best legal estrogen inhibitor on the market !?

YoungBodyBuil said:
i thought formestanes conversion rate to 4-hydroxy is rather low?
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To the contrary. Seems as though it's fairly significant. See, for instance: docdro.id/yrwT4El & docdro.id/67l4uLz
To sum up in a couple of sentences: Via the oral route, in humans, formestane and 4-OHT were indistinguishable -- they had the same exact metabolites -- which suggests ready interconversion. In rhesus monkeys, intravenously, a very significant fraction of the formestane administered converted to 4-OHT.

...Which is not to say that formestane is much of an anabolic. But, via conversion to 4-OHT, it's very likely to have a positive impact where mood, energy levels, sex drive, etc. are concerned.
 
JakeAntaeus said:
To the contrary. Seems as though it's fairly significant. See, for instance: docdro.id/yrwT4El & docdro.id/67l4uLz
To sum up in a couple of sentences: Via the oral route, in humans, formestane and 4-OHT were indistinguishable -- they had the same exact metabolites -- which suggests ready interconversion. In rhesus monkeys, intravenously, a very significant fraction of the formestane administered converted to 4-OHT.

...Which is not to say that formestane is much of an anabolic. But, via conversion to 4-OHT, it's very likely to have a positive impact where mood, energy levels, sex drive, etc. are concerned.
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Well what would you say about it being used in a PCT Scenario?
 
JakeAntaeus said:
To the contrary. Seems as though it's fairly significant. See, for instance: docdro.id/yrwT4El & docdro.id/67l4uLz
To sum up in a couple of sentences: Via the oral route, in humans, formestane and 4-OHT were indistinguishable -- they had the same exact metabolites -- which suggests ready interconversion. In rhesus monkeys, intravenously, a very significant fraction of the formestane administered converted to 4-OHT.

...Which is not to say that formestane is much of an anabolic. But, via conversion to 4-OHT, it's very likely to have a positive impact where mood, energy levels, sex drive, etc. are concerned.
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I've used it three times, and I'd def agree with that. I didn't feel it leaned me out as well as other AIs but the "alpha" feeling was very present while using it. Slept better, had more energy, sex drive was increased.
 
Personally I have used Inhibit-E in the past with pretty good results. The only other I have heard really good about is formastane.
 
JakeAntaeus said:
Incorrect. It's because a rather significant amount of formestane would convert to 4-hydroxy-testosterone, which is, of course, an androgen.

Invalid Link Removed
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Would you agree that this data suggests that the majority of both form and 4-OHT's activity are via their 5a reduced metabolites?

I was also wondering if I could pick your brain on how to form cyclodextrin complexes... Not to derail here but via PM if you're willing.
 
nostrum420 said:
Would you agree that this data suggests that the majority of both form and 4-OHT's activity are via their 5a reduced metabolites?

I was also wondering if I could pick your brain on how to form cyclodextrin complexes... Not to derail here but via PM if you're willing.
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:D too late. The threas is already derailed.

But I'd say that feel free to discuss it here. I think many would be interested.
Just add a simple summary too if you get too technical.
 
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nostrum420 said:
Would you agree that this data suggests that the majority of both form and 4-OHT's activity are via their 5a reduced metabolites?

I was also wondering if I could pick your brain on how to form cyclodextrin complexes... Not to derail here but via PM if you're willing.
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No. The major 5a-reduced metabolites of formestane have been tested for aromatase inhibitory activity, and appear to be completely inactive. See: "Pharmacokinetics and metabolism of formestane in breast cancer patients", available at docdro.id/jtu0Ewl

What's more, formestane's potency has been demonstrated in dozens of aromatase enzyme assays, where such metabolites would not play any role. Its potency in these assays roughly predicts its real-world potency: In vitro, it's about 50x less potent than letrozole -- in vivo, accounting for bioavailability and pharmacokinetic differences, it's about 50x weaker than letrozole. We must therefore infer that it is inherently active, and we have no basis for supposing that it's a prodrug to a "real" aromatase inhibitor like a 5a-reduced metabolite.

The situation is not different where 4-OHT is concerned. 4-hydroxy-5α-dihydrotestosterone would be, almost certainly, a reasonably potent anabolic. But 4-OHT doesn't appear to convert to it -- that particular molecule is not shown on the chart, nor mentioned among the list of metabolites. All of the metabolites shown and mentioned are, almost certainly, inherently inactive as anabolic agents. Or very nearly so.

Please feel free to PM me.
 
Female Hormone Panel with 15% off coupon is like $42-45. Isn't comprehensive but is enough to determine if you've recovered in PCT.
 
Just use cats claw and Resveratrol both 500mg daily and see if it stops your morning woods because estrogen being too low
 
619sss said:
Why? High dose? Side effects? Better option? I want to learn.
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There are definitely better options ITT than either of those.
 
619sss said:
Why? High dose? Side effects? Better option? I want to learn.
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The cats claw I'd be very wary of relying on for E control. In general, I only believe in standardized extracts for herbal stuff.

As for the Rez, again I wouldn't rely on it. Yes it's been shown have some anti-E properties but I doubt it would be sufficient on its own to achieve the intended effect.

Also if you're pushing your E so low that it causes ED/lack of morning wood, you're doing it wrong.
 
nostrum420 said:
Also if you're pushing your E so low that it causes ED/lack of morning wood, you're doing it wrong.
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Shameless plug on Invalid Link Removed here.

Direct from the writeup:
Remember, maintaining normal levels of estrogen is an important part of maintaining libido, muscle recovery, and testicular function. Therefore, it is undesirable to overly suppress estrogen levels. The natural anti-estrogens in Sustain Alpha gently balance and control estrogen levels, without overly suppressing them.
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nostrum420 said:
The cats claw I'd be very wary of relying on for E control. In general, I only believe in standardized extracts for herbal stuff.

As for the Rez, again I wouldn't rely on it. Yes it's been shown have some anti-E properties but I doubt it would be sufficient on its own to achieve the intended effect.

Also if you're pushing your E so low that it causes ED/lack of morning wood, you're doing it wrong.
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Yes I know I dropped my E too much but I didn't know how much the dosage must be and how long, I looked it up in examine, well it worked but too much.... I just wanted to get the extra test from estrogen for strength. But it was a high dose compared to commercial anti estrogen products
 
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