What is Peg-HGH ??
- Thread starter Whacked
- Start date
Bobaslaw
Member
In short it is Pegylated HGH. Pegylation (binding of Polyethylene glycol to the HGH peptide) increases the half life of the peptide in the body thus reducing the frequency of injections.
Read this for more detailed info:
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Take Care.
Whacked
Well-known member
Bobaslaw
Member
the big question is will it work better than regular HGH in our bodies. give me a supply and i will let you know.
Well, take a look at Chart #10 towards the bottom that shows actual serum levels of IGF after a single 180mcg dose/rat of Peg-HGH (filled circles on chart), vs daily 30mcg/rat dose of regular HGH (unfilled squares on chart).
Seems very nice to me. Also, IGF levels were higher with Peg vs HGH (thus GH was higher) for 7 days, where finally both concentrations met at the same levels. Seems that you can use much less Peg (mg per mg) than regular HGH to achieve similar levels....
Chart #10
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BTW, there seem to be many variants of Peg-HGH. Some have more than one peg molecule bound to the HGH portion. This does impact the longevity of the HGH to different degrees.
pumbertot
Active member
sounds really good, thanks for the info(once again).
no I dont believe he is using it. Im not sure if its widely available as of yet but will be harrassing my supplier for this.
Bobaslaw
Member
sounds really good, thanks for the info(once again).
no I dont believe he is using it. Im not sure if its widely available as of yet but will be harrassing my supplier for this.
Yep, I'm still in harrasment mode here too
djbombsquad
Board Sponsor
Looks interesting. Stack that with pegmgf maybe? I see some future logs comming around the bin.
Bobaslaw
Member
It's HGH, so apply it to whatever protocol you would use HGH with.... No need to guess here.
SOLARUS
Member
AGREED - the research i've done on PEG-HGH strongly suggest that it's the dog's balls (bee's knees if you prefer)...i expect that if the price ever comes down enough to make its use widespread, the only limiting factor besides cost will be SIDES, as that much of an increase is bound to cause even more of the often-unwanted GH sides (forearm pain, sleep difficulty, hypoglycemia, water retention, etc)sounds really good, thanks for the info(once again).
no I dont believe he is using it. Im not sure if its widely available as of yet but will be harrassing my supplier for this.
Bobaslaw
Member
Going by the graph of IGF levels from one 180mcg/rat injection (peg) vs daily 30mcg/rat injections(reg. HGH), I can see the possibility that dosage frequency could be increased (twice/week) and dosage amount could be decreased to half (more or less). Possibly even 1/3 dosage E3D...
Similar tweaking could get more stable baseline levels than one injection every 7 days...
IGF Chart is at the very bottom
Filled Circles= one 180mcg Peg-HGH Injection
Open Squares=daily 30mcg Regular HGH injections
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SOLARUS
Member
so weird that 300 mics of HGH didnt elevate IGF, even immediately after injection.
off topic - anybody ever heard of a peptide that binds to the IGF-1 binding protein?
Bobaslaw
Member
Bobaslaw
Member
I assume that IGF production increases much more significantly with a constant "around the clock" GH agonism as with Peg-HGH, than with even a single higher dose of GH which would spike and be gone very quickly.
The difference is pretty amazing.
Bobaslaw
Member
Here is one link to a study about IGFBP displacers. The do not however divulge the exact peptides they used, just said that these novel synthetic peptides show promise... Depends also which IGFBP as IGFBP-3 primarily binds to IGF.
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Some info on NBI-31772 non specific IGFBP inhibitor:
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Ligand Inhibitors of IGFBPs:
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Some more possible info:
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SOLARUS
Member
it looks like the only thing that even significantly increased IGF-1 in that study is peg-HGH. none of the other protocols exceed baseline. very odd.
SOLARUS
Member
thanks for the research my man...