If you've had gyno for 10+ years, nothing over the counter will really fix it. I've been down that road and had it removed surgically. I tried Letro which does make them less puffy for the time 'on' Letro, but once off, it slowly returned. Axis Lab's Furazdrol flared up my nipple so I suggest staying away from that. I'm trying Epidrol now and may be feeling something in my left nip again so I may stop if it's still there tomorrow. But I'm not using Epi to remove the gyno, I'm using it to put on a little weight. If you're using it to remove it, it probably won't do anything.