URSOL-XT

jwa254 said:
I went ahead and purchased two bottles. I've heard good things about FRL as a company so I figured the gamble is worth it. I have 1.5 bottles of ursobolic left that I'll be finishing up before I switch over to try Ursol-XT, though. I started out with 4 bottles of ursobolic and have been running at 9/day mostly (I've ran a few cheat days at 12/day). I know it's purely anecdotal (however, most customer reviews are), but I'm visibly leaner and weight hasn't fluctuated more than a pound. I've also noticed some appetite suppression as well. I figure, if anything, Ursol-XT will be sufficient enough to produce results regardless of whether the cyclodextrin truly helps or not.

If the dose of UA per 4 caps turns out to be too low for my tastes, I'll trying adding 1-2 caps of ursobolic with it.
Click to expand...

Ursolic Acid is really a good compound. We still think the big issues with it are the solubility. And getting it complexed will improve it greatly. Just so you guys dont think I'm full of it....here is the research:

Invalid Link Removed 2006 Feb 14;12(6):874-9.[h=1]Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana.[/h]Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed.
[h=3]Source[/h]Department of Pharmacology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China. [email protected]

[h=3]Abstract[/h][h=4]AIM:[/h]To investigate the anti-tumor activity of ursolic acid (UA) and its derivatives isolated from Aralia decaisneana on hepatocellular carcinoma both in vitro and in vivo.
[h=4]METHODS:[/h]In vivo cytotoxicity was first screened by 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay. Morphological observation, DNA ladder, flow cytometry analysis, Western blot and real time PCR were employed to elucidate the cytotoxic mechanism of UA. Implanted mouse hepatoma H22 was used to evaluate the growth inhibitory effect of UA in vivo.
[h=4]RESULTS:[/h]UA could significantly inhibit the proliferation of HepG2 and its drug-resistance strain, R-HepG2 cells, but had no inhibitory effect on primarily cultured normal mouse hepatocytes whereas all the six derivatives of UA could not inhibit the growth of all tested cell lines. Further study on mechanism demonstrated that apoptosis and G0/G1 arrest were involved in the cytotoxicity and cleavage of poly-(ADP-ribose)-polymerase (PARP). Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA. In addition, UA also could inhibit the growth of H22 hepatoma in vivo.
[h=4]CONCLUSION:[/h]UA is a promising anti-tumor agent, but further work needs to be done to improve its solubility.

PMID: 16521214 [PubMed - indexed for MEDLINE]

Free full text
Click to expand...


Invalid Link Removed 2009;10(4):1137-44. Epub 2009 Oct 16.[h=1]The influence of cosolvent on the complexation of HP-beta-cyclodextrins with oleanolic acid and ursolic acid.[/h]Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed.
[h=3]Source[/h]Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, People's Republic of China.

[h=3]Abstract[/h]The present work was aimed at the influence of ethanol on the complex formation of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) with oleanolic acid (OA) and ursolic acid (UA), two insoluble isomeric triterpenic acids. Phase solubility studies were carried out to evaluate the solubilizing power of HP-beta-CD, in association with ethanol, toward OA and UA. A mathematical model was applied to explain and predict the solubility of OA and UA influenced by HP-beta-CD and ethanol. The solid complexes were prepared by evaporating the filtrate of samples which was prepared in different complexing media. The solubility of OA is much higher than that of UA in all the tested aqueous solutions. The solubility of OA and UA can be increased over 900 and 200 times, respectively, by forming complex with HP-beta-CD. Ethanol (0.5%, v/v) can help the formation of OA-HP-beta-CD complex, but is harmful to the formation of UA-HP-beta-CD complex. Increasing solubility in water can be achieved by adding ethanol into the complexing media, but the concentration of ethanol should be optimized. The ring E of the chemical compounds has a great influence on the complexing process.

PMID: 19834815 [PubMed - indexed for MEDLINE] PMCID: PMC2799583

Invalid Link Removed
Click to expand...
 
Royd The Noyd said:
Ursolic Acid is really a good compound. We still think the big issues with it are the solubility. And getting it complexed will improve it greatly. Just so you guys dont think I'm full of it....here is the research:
Click to expand...

Haha no worries, big man. I hope you guys can get it complexed. Like I said, I'm loving UA right now and I'm only a few weeks in, so add forskolin and piperine in it and I think some sweet synergy will occur.
 
SynergyIre said:
So you're still going to ship it as is and then later come out with the version you intended?
Click to expand...

I'm assuming they're shipping as is as the batches have been made already. If they find some one to complex it for them, they'll release that later.
 
So the product was pitched one way but doesn't actually meet the claims as admitted. Does the product still go out at the same price? I think half off sounds like a good deal to clear stock and rush the new batch into production.
 
Would dosing it a little higher be bad because of the extra forskolin in there?

BTW, mad props to you guys for living up to your mistake. Takes a lot to do that. Though I have yet to try a product from you guys Ill be more inclined to try one now that I know how legit you guys are.

Good job guys!
 
mattrag said:
Would dosing it a little higher be bad because of the extra forskolin in there?

BTW, mad props to you guys for living up to your mistake. Takes a lot to do that. Though I have yet to try a product from you guys Ill be more inclined to try one now that I know how legit you guys are.

Good job guys!
Click to expand...

As long as you work up to the dose you will be fine. Forskolin causes some toilet issues for some people.

I promise you our next product will be perfect.
 
Royd The Noyd said:
That's correct. We are not advertising any improved solubility since it is irrelevant
Click to expand...

Hmm hope you guys didn't have to pay for a botched job :( . Think I'll be waiting for logs to come out now. Little sad you guys have decided to accept second best on this, hoping it still works great though.
 
SynergyIre said:
Hmm hope you guys didn't have to pay for a botched job :( . Think I'll be waiting for logs to come out now. Little sad you guys have decided to accept second best on this, hoping it still works great though.
Click to expand...

I'll probably run a log. If so, I'll post a link in here.
 
If there is no significantly improved solubility, can we have an idea of how much ursolic acid is in each serving. I would like to know so I can continue the dosing protocol with this instead of ursobolic. If the solubility was better I'd be willing to experiment with dosing, but for now I would keep it steady.
 
johnfaceman said:
If there is no significantly improved solubility, can we have an idea of how much ursolic acid is in each serving. I would like to know so I can continue the dosing protocol with this instead of ursobolic. If the solubility was better I'd be willing to experiment with dosing, but for now I would keep it steady.
Click to expand...

Agreed

I want to try this for the forskolin addition.. But need to know how much ua I'm Getting per cap to match my current 9 pills daily of ursobolic. Thanks
 
HMMM just herd from Royd that there is a pre order sale going on right now for Ursol-XT :)
 
Lol got it.. Any number yet on amt of ua per cap/serving?? Would like to at least make the minimum I'm at with 450mg daily right now
 
Royd The Noyd said:
Hey guys sorry for the delays in replies. We had all sorts of issues come up and we needed to fix them.

Originally the plan was to complex the UA in cyclodextrin. We wanted to do this because it increases the solubility of UA 200 times. But we got bad news.

We used a new manufacturer, who basically priced it as complexed. We thought we were good to go. By the time they completed and we had labels printed and we tested the final product we found all they did was blend our UA with cyclodextrins. They didn't actually complex it which is what really matters. At this point we went back to them but they want to charge a ridiculous amount for complexing the product. Egh

So where does that leave us. The cyclo in the product doesn't actually improve solubility. So this is just plain ole UA.

However the additions of piperine and forskolin still work well with UA. We are also continuing to pursue a manufacturer who can appropriately complex the cyclos.


FRL sincerely apologizes for this error. But hopefully this provides some clarification.
Click to expand...

:(

so when can we expect the better version?
 
Royd The Noyd said:
Hey guys sorry for the delays in replies. We had all sorts of issues come up and we needed to fix them.

Originally the plan was to complex the UA in cyclodextrin. We wanted to do this because it increases the solubility of UA 200 times. But we got bad news.

We used a new manufacturer, who basically priced it as complexed. We thought we were good to go. By the time they completed and we had labels printed and we tested the final product we found all they did was blend our UA with cyclodextrins. They didn't actually complex it which is what really matters. At this point we went back to them but they want to charge a ridiculous amount for complexing the product. Egh

So where does that leave us. The cyclo in the product doesn't actually improve solubility. So this is just plain ole UA.

However the additions of piperine and forskolin still work well with UA. We are also continuing to pursue a manufacturer who can appropriately complex the cyclos.

FRL sincerely apologizes for this error. But hopefully this provides some clarification.
Click to expand...
Buuuuummmmmer....
 
Sooo I'm glad you his didn't leave this hidden and have fold assume they were getting a complexed cyclo product.... But I don't think I'll be picking until its released in that form...

Really the differences will bee absurd between the 2 given the increased adsorption...
 
Sounds excititing......

Im on this if it means gulping down less ursobolic pills (18per day)

any idea when the first or improved batch will be avail in the UK ?

does this have more promise than c20 ? (still unsure if this actually contains any UA)

and do we know exactly how much actual UA is in each serving of 4 pills?
or is the amount of UA per serving just 25% of the whole prop blend (not alot)

In simple terms what was the prob with the first batch and how will the second be better?

coleus forskolin (standardised) is known to boost t levels hence why label apparantly mentions drug testing

Thanks
 
I really hope you guys can bring out the complexed version soon. I was looking forward to this product.
 
SynergyIre said:
Is this 600mg of 25% Ursolic Acid? I ask considering it says 1280mg serving for 4 caps, meaning 320mg per cap and the ingredient list says Ursolic Acid 25%.
Click to expand...

Exactly, 600mg of a 25% extract? That means 150mg of ursolic acid per serving(4 caps). That's equivalent to 3 ursobolic caps. I also wonder why piperine is dosed higher than forskolin and what extract the foskolin is.
 
Ev52 said:
Exactly, 600mg of a 25% extract? That means 150mg of ursolic acid per serving(4 caps). That's equivalent to 3 ursobolic caps. I also wonder why piperine is dosed higher than forskolin and what extract the foskolin is.
Click to expand...

Wondering why no one else is asking this... If it's only 150mg then not having something added absorption is kinda a big deal. Really a question of how much piperine helps, but the complex seems to be what they were really banking on.

Didn't notice piperine above forskolin... Good question :)
 
SynergyIre said:
Wondering why no one else is asking this... If it's only 150mg then not having something added absorption is kinda a big deal. Really a question of how much piperine helps, but the complex seems to be what they were really banking on.Didn't notice piperine above forskolin... Good question :)
Click to expand...
Hmm, I bought this based on the post below Royd's post saying 4 caps (FRL)= 12 caps (E-pharm)
schizm said:
= to 12 caps of Urso...for those keeping track ;) Outstanding FRL :veryhappy:
Click to expand...
If this was not a correct statement someone should have clarified. I know it wasn't from Royd's mouth, but I may have just paid almost 2 times (compared to e-pharms) more for something that will last me 5 days at the dose I intended to run it. This would be awful. Not trying to bad mouth as i am a fan of FRL. But if this is true I really wish FRL would have clarified these questions. Please clarify ASAP Royd as I will deny shipment if this is true. Can't quite afford $138 for a months worth of ursolic acid
 
johnfaceman said:
Hmm, I bought this based on the post below Royd's post saying 4 caps (FRL)= 12 caps (E-pharm) If this was not a correct statement someone should have clarified. I know it wasn't from Royd's mouth, but I may have just paid almost 2 times (compared to e-pharms) more for something that will last me 5 days at the dose I intended to run it. This would be awful. Not trying to bad mouth as i am a fan of FRL. But if this is true I really wish FRL would have clarified these questions. Please clarify ASAP Royd as I will deny shipment if this is true. Can't quite afford $138 for a months worth of ursolic acid
Click to expand...

That post would be from schizm who's a rep for SNS. This question was brought up in a different way on page 7, where if it was 25% Ursolic Acid, if the whole formula was 25% UA, since the full dose of 4 caps is 1280mg the MAXIMUM dose possible would be 320mg of pure ursolic acid, and again that assumes there's nothing else in the formula. I'm sure piperine increased the absorption of the UA, the question is still by how much.

Hopefully Royd can speak to this a bit. I would hope that they wouldn't put out the product if they didn't think it would perform at this amount. Would be nice to have a response to this from someone more involved in the formulation.
 
Yea unfortunately I'm holding off til the formula is corrected n we get some numbers.. Gonna finish off my 3 remaining bottles of urso and hopefully by then things here will be settled up
 
Doubt its 25% of the total formula as UA is very commonly standardized to 25%. I can't be certain but i would assume the 25% is simply the extract percentage. I really hope someone can clear up these speculations.
 
chedapalooza said:
Yea unfortunately I'm holding off til the formula is corrected n we get some numbers.. Gonna finish off my 3 remaining bottles of urso and hopefully by then things here will be settled up
Click to expand...

Yeah, I truely hope I'm wrong, just more worried about the silence on the matter...
 
chedapalooza said:
Yea unfortunately I'm holding off til the formula is corrected n we get some numbers.. Gonna finish off my 3 remaining bottles of urso and hopefully by then things here will be settled up
Click to expand...
Now I really wish I did the same. I'm just praying I'm not stuck with 2 bottles that will only last me 10 days total. Does anyone know if BRSupps has a return policy?
 
Seeing as how the product was pitched one way when this thread started and then all the sudden the delivery system is a bust I would not buy it. I do applaud the admission of the problem, but I still wouldn't purchase it. As far as I can tell the pricing etc was done with the delivery system in mind and then it's useless and the price stays the same. I don't know maybe I'm seeing it wrong, but with so much confusion over what this product is and isn't I will be staying away from it most likely.
 
johnfaceman said:
Now I really wish I did the same. I'm just praying I'm not stuck with 2 bottles that will only last me 10 days total. Does anyone know if BRSupps has a return policy?
Click to expand...

If it comes down to UA being underdosed, just pick up some Ursobolic and dose along side the 4 caps a day of Ursol-XT. That way you get benefit of the piperine not to mention the forskolin which should be an awesome stack anyways, which for the money might still work out to be a decent deal at the price.

There are still ways to make this supplement workable either way, would just be nice to know all the facts :)
 
Yea the forskolin is the biggest draw IMO.. Maybe just add it alongside urso.. I'm gonna be taking something soon with it anyway so.. Well see how it works out
 
unfortunately I'll be waiting until the next batch..

I'll probably just add some piperine with my current ursobolic and see if it does anything.
 
dlucks said:
unfortunately I'll be waiting until the next batch..

I'll probably just add some piperine with my current ursobolic and see if it does anything.
Click to expand...

I wouldn't expect it to by much given its more likely absorbed predominantly through the lymphatic system, not the liver.... Thus the suggestion to take with fats...

Had it actually been complexed with the cyclo then we would have a whole different animal on our hands...

I think it would be worth the costs to do that just cause of the increased adsorption alone.... Mg:mg there would be way more value in cyclo complexed ursobolic then standard...

Please make this happen guys, I'm sure it will wind up being something special...
 
Hey guys sorry to bring up such an uproar my bad :) But like Royd said it was a mnf/label issue that i posted incorrect about mg/per caps...etc.. I was doing some research and all that multitasking got me screwed up.. so i apologize for any wrong info that i posted.. I honest did not mean that by any wrong doing. We stand behind our products 100% with any or all actives we provide. As for any more questions you might have, i will be sure to pass along to Royd as the hopes he can answer asap. This is why FRL was big on Alpha Mass sales by providing high quality products at lowest possible price. When we sold out AM within months of retailers getting, thats telling me our fans/customers are TRULY THE BEST OF THE BEST. We can't wait for all of you to see our entire line to come out to be all of you happy. Ok so as far as me, i'm old and decrepit was trying to do to much at one time. So again, i apologize on my behalf and hope for continued support from Anabolic Minds posse.. PLEASE again we will be more happy to get back asap with any questions...ok im going back to bed as the flu has kick my elder ass
 
You must log in or register to reply here.
Back
Top