Triacetyl-Adenosine?

BigGame84

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Yes, very interested. Would purchase a lot.

Pump Spray was TAA with Ursolic Acid but I think Epicatechin is better for pumps than Ursolic Acid.

I've talked to Pat and Prototype has an oral version in the works (better than the previous version from years ago) but it's been taking Pat years to get it out.
 
nostrum420

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Adenosine
Michael P. DeNinno, in Annual Reports in Medicinal Chemistry, 1998

"Adenosine is essential for the proper functioning of every cell in the body. It is a component or precursor to a component of RNA and DNA, and in its native form, or in various phosphorylated states, acts as a neurotransmitter at the P1 and P2 purine receptors. The intra- and extra-cellular levels of adenosine are tightly regulated through its production from ADP and ATP, transport through specific nucleoside transporters, and catabolism."
 
BigGame84

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Oral TAA required at least 2g to notice much in the way of pumps and endurance. I'd guess transdermal might be more effective at a lower dose?
 
megadeth

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1000%
 
xR1pp3Rx

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im thinking.. its a yes!
 
BigGame84

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This is probably more geared to a pre-workout only type of product.
 

dcoen21

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Hopefully td will fix its main problem and increase half life, can we expect this is the coming months or are Raws still hard to find??
 
ANABOLICWRWLF

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I've never used TAA and couldn't find much info other than on Pump Spray specifically. Can some gracious brother hook it up with a link to a write up somewhere that's not just a product description?

Edit: if such a write up exists that is!
 
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nostrum420

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I've never used TAA and couldn't find much info other than on Pump Spray specifically. Can some gracious brother hook it up with a link to a write up somewhere that's not just a product description?

Edit: if such a write up exists that is!
"Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the world. There is growing evidence that they could also be promising therapeutic targets in a wide range of conditions, including cerebral and cardiac ischaemic diseases, sleep disorders, immune and inflammatory disorders and cancer. After more than three decades of medicinal chemistry research, a considerable number of selective agonists and antagonists of adenosine receptors have been discovered, and some have been clinically evaluated, although none has yet received regulatory approval. However, recent advances in the understanding of the roles of the various adenosine receptor subtypes, and in the development of selective and potent ligands, as discussed in this review, have brought the goal of therapeutic application of adenosine receptor modulators considerably closer."

 
ANABOLICWRWLF

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"Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the world. There is growing evidence that they could also be promising therapeutic targets in a wide range of conditions, including cerebral and cardiac ischaemic diseases, sleep disorders, immune and inflammatory disorders and cancer. After more than three decades of medicinal chemistry research, a considerable number of selective agonists and antagonists of adenosine receptors have been discovered, and some have been clinically evaluated, although none has yet received regulatory approval. However, recent advances in the understanding of the roles of the various adenosine receptor subtypes, and in the development of selective and potent ligands, as discussed in this review, have brought the goal of therapeutic application of adenosine receptor modulators considerably closer."

So if I had to take a stab at it, TAA is an adenosine antagonist like caffeine but without its vasoconstrictive qualities and perhaps actually causing dilation?
 
nostrum420

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So if I had to take a stab at it, TAA is an adenosine antagonist like caffeine but without its vasoconstrictive qualities and perhaps actually causing dilation?
Subjectively some people who have used TAA report some increases in energy or endurance but TAA is a prodrug to adenosine. So, it's going to turn into adenosine itself (which would obviously be an adenosine receptor agonist.) So, if there is an increase in energy, it's possible that the acetylated form is acting as an antagonist before it's metabolized into adenosine but I think if there is an energy boost from it, it's more likely due to some downstream effect.

If the above is the case, the most obvious explanation, in my opinion, would be that the adenosine is quickly metabolized into cAMP, ADP and ATP enhancing the capacity of the Krebs cycle to release stored energy by oxidizing carbohydrates, fats and proteins.
 
wfreiling

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So what does this do? Haha like really dumb it down for this guy(me)
 
nostrum420

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So what does this do? Haha like really dumb it down for this guy(me)
TBH, finding out what, if anything, peoples' subjective results were, (which is what I think you're asking for) is the reason I started this thread.

Like you want to know, if you take some what are you going to feel, right? It would appear the answer from the comments above is "pumps and endurance."
 
ANABOLICWRWLF

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It would appear the answer from the comments above is "pumps and endurance."
the most obvious explanation, in my opinion, would be that the adenosine is quickly metabolized into cAMP, ADP and ATP enhancing the capacity of the Krebs cycle to release stored energy by oxidizing carbohydrates, fats and proteins.
Seems like a logical correlation there and a promising one at that.
 
xR1pp3Rx

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i thought i remember this always being in fat burners back in the day. so it must produce some effects there too.. again like you said, maybe something with the cAMP or the Krebs cycle.
 
nostrum420

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i thought i remember this always being in fat burners back in the day. so it must produce some effects there too.. again like you said, maybe something with the cAMP or the Krebs cycle.
Quite possibly. It seems to me this hasn't really been fully explored. Almost all of the Adenosine supps whether its actually ATP, TAA or whatever else have been oral and probably only PAs was capable of being effectively dosed and that was only available for a short time, as I understand it.

So, I think if I can put out an effectively dosed TD, we may see some effects or applications that we don't currently associate with these products.

I'm putting the cart before the horse here seeing as the raws are still in transit but I'm interested in seeing before and after bloodwork, for a lot of reasons but I'm particularly interested in effects on lipids and BP.
 
JKVol

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If the above is the case, the most obvious explanation, in my opinion, would be that the adenosine is quickly metabolized into cAMP, ADP and ATP enhancing the capacity of the Krebs cycle to release stored energy by oxidizing carbohydrates, fats and proteins.
So it could also assist with fat loss?

Edit: just seen the post above
 

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