Trestolone as a PH or DS “Base”
There has been an increasing amount of “base” threads lately so I’m going to copy and paste a few snippets from one of my blog articles.
Trestolone is a new compound currently being used in trials for various purposes by pharmaceutical companies. The possible uses for this compound reside in the fields of hormone replacement therapy and a possible male contraceptive (I’ve waited long enough for one of these lol). The excitement surrounding this compound is its abilities to fulfill the mechanisms that testosterone does.
To understand the implications of this we will take a quick look at testosterone and a few of the processes it is involved in. Testosterone is a precursor to the hormones DHT (dihydrotestosterone) – the primary androgen - and estrogen. DHT and estrogen are synthesized via testosterone reduction by specific enzymes. The enzymes for these reactions are 5AR (5-alpha reductase) and estrogen synthetase (aromatase). Both of these hormones must be biosynthesized to maintain homeostasis (normal bodily balance/operation). Testosterone is reduced quite significantly in the body via conversion to other hormones and being bound up substantially by SHBG (sex hormone-binding globulin).
ENTER TRESTOLONE
Trestolone from what we have seen in the studies fulfills these roles with great efficiency, either by direct conversion to a potent estrogen (7-alpha-methyl-estradiol) via aromatase or by the high androgenic nature of the hormone, making up for the absence of DHT conversion. 7-alpha-methyl-estradiol, has much greater binding affinity for the ER (estrogen receptor) making it a more potent estrogen than estradiol itself. This does indicate the need for an aromatase inhibitor ran concurrently to minimize high estrogen side effects. Remember though guys we want to control estrogen not crush it.
Trestolone unlike testosterone does not bind to 5AR, which limits the conversion to DHT. DHT again is important due to its androgenic effects. From early anecdotal feedback (the logs), we have seen that even with the absence of DHT conversion the high androgenic nature of Trestolone seems to make up for the lack of this conversion. Trestolone also holds no affinity for SHBG, which allows for high levels of the circulating hormone to be bound to the receptor instead of SHBG. The high affinity for the AR (androgen receptor) is likely the pathway that makes up for its lack of DHT conversion. I have seen it posted that DHT is more androgenic than Trestolone however, where Trestolone may lack an androgenic ratio comparable to that of DHT it seems to make up for by not binding to SHBG. DHT like testosterone does bind strongly to SHBG whereas Trestolone does not.
Now the translation into why Trestolone is the best choice for an on cycle “base”. As we all well know or may not know. When consuming an exogenous hormone source our own natural testosterone production (testosterone biosynthesis) is downregulated. Once suppression occurs, what we are left with is the hormone in which we have introduced to our system. Some of these hormones can have side effects such as loss of libido, fatigue, mood decreases etc. What some are not aware of is that these side effects can sometimes be directly attributed to the fact that downregulation has occurred giving you little to no endogenous testosterone.
With the absence of testosterone, is the absence of the previously mentioned testosterone metabolites – DHT and estrogen. When all of these hormones, including testosterone, are downregulated, you will feel the effects of suppression, which can directly affect mood, libido, energy, and so forth. To correct this problem many people resort to using exogenous testosterone (out of body). The problem with this is you are either toeing the line of legality, straight up breaking the law or using prohormones that have low conversion rates to testosterone such as 4 DHEA etc. Other possible bases that people use are prohormones to stanolone (DHT), DHEA products, and the like. These options have been used with success for quite some time. That is until now.
Trestolone as seen in the studies and anecdotal feedback can indeed be used as a viable and potent option for a base alternative. The reason for this is the ability to fulfill the mechanisms outlined in this article. It can convert to estrogen, albeit a more potent estrogen but estrogen none the less. What this does for you is keeps your body in a homeostatic (normal operating) state. You still have adequate estrogen levels keeping your mood, libido, erection function and quality up etc. Due to the androgenic nature and lack of SHBG affinity of Trestolone you also get the androgenic benefits that you would with DHT conversion, which can also effect libido, mood, aggression, energy etc.
Any other questions post them up or to add input post it up.
Good luck
-V