OP to your original question regarding toxicity, I would only be concerned about the potential heavy metal contamination (for starters) in some supps, especially herbals. Many of these ingredients originate in countries where pollution and contamination are endemic to the soil or storage of said compounds. Not to mention the potential pesticide contamination. Thus, I'd worry more about brain health than liver and kidneys. As a rule, the liver can recover and you have two kidneys.