We were very surprised when we started looking into forskolin. It's very popular as a pharmaceutical probe compound for cell-line experiments, but it turns out that the data on its use in humans or animals is very poor.
There's Invalid Link Removed -- as far as I can tell, available only in Chinese -- which states that the oral bioavailability of Forskolin in rats is 0.52%. (Table 2, F(%). I can't read Chinese, either, but that part's fortunately clear!)
The fulltext of the paper I linked to previously is Invalid Link Removed, and its reference #4 is that Chinese paper. This newer paper indicates that solubility, not permeability, is what limits forskolin's oral bioavailability. That, in other words, it's a classic Invalid Link Removed -- and a very extreme example of that type, as its solubility in water seems to be somewhere under 0.01mg per ml.
Forskolin also happens to be a P-gp substrate, which means that there's a protein that tries to block its absorption -- and, if absorbed, tries to kick it out of circulation. This, in itself, typically reduces bioavailability quite markedly.
And then there's the twist. The paper closes with: "Unfortunately, no studies describing the metabolism of forskolin in vivo have been reported so far." As far as I can tell, this was true at the time the paper was written, and it remains true now. Even if forskolin is absorbed, what happens to it from that point on is anybody's guess.
So forskolin is a compound with near-zero solubility, which also happens to be a P-gp substrate, and nobody knows how it's metabolized. Seems to me that 0.52% bioavailability is pretty good, under the circumstances! But it still means that of a 50mg dose of forskolin, only ~250mcg can be utilized.
Back on topic: I don't think that people who buy Ultratest are "N=1 labrats." Tongkat Ali is already very highly regarded and well-studied as a testosterone booster, and here it's combined with liquid VD3 and K2 -- the latter at a real solid dose. In addition to that already solid base, the product contains a couple of innovative ingredients, which we're very proud of, and which should impart many additional benefits.
Does this need to be cycled? Its a hell of big dose of K2.
Can this be combined with other boosters if there is no ingredient overlap? I am finishing another brand that is Aswaganda heavy which will remain unspoken.
How do/does test boosters/this product more specifically stack with other "Bulking" supplements? I've never supplemented with a "test booster" since I've always read that they were for the most part a waste. Libido gains are of no concern to me.
For reference, I have a 3 month bulk I will beginning in 2 weeks stacking Vector & Follidrone. I also typcially supplement in 50mg of forskolin while bulking. Would this product work well with those supplements or is there not much to be gained by stacking it?
Does this need to be cycled? Its a hell of big dose of K2.
Can this be combined with other boosters if there is no ingredient overlap? I am finishing another brand that is Aswaganda heavy which will remain unspoken.
Guys we have reached the final Day! If you have been on the fence, get off and get some!
View attachment 171484
He is a nice looking man, but I am not so sure I would go that far..Just watching the bottle gives me T increase.
Sexy design !
He is a nice looking man, but I am not so sure I would go that far..
Oh, the bottle. Yes, very sharp!
I was going to order this morning because when I got on at 9 last night it said 15 hours left
Why did you have to put vitiman d in it? I have a calcium disorder I can't take vitamin d. They already put it in damn near everything why can't you guys just stick to the novel ingredients and leave the basic crap thats in everything out of it?
Ill be able to take this for a couple weeks thats about it. Its my own fault for not checking the label more carefully. I thought this was a single ingredient product.
Why did you have to put vitiman d in it? I have a calcium disorder I can't take vitamin d. They already put it in damn near everything why can't you guys just stick to the novel ingredients and leave the basic crap thats in everything out of it?
Ill be able to take this for a couple weeks thats about it. Its my own fault for not checking the label more carefully. I thought this was a single ingredient product.
Why did you have to put vitiman d in it? I have a calcium disorder I can't take vitamin d. They already put it in damn near everything why can't you guys just stick to the novel ingredients and leave the basic crap thats in everything out of it?
Ill be able to take this for a couple weeks thats about it. Its my own fault for not checking the label more carefully. I thought this was a single ingredient product.
Danes is right. VD3 is in the product because vitamin D deficiency is common, and is associated with low testosterone levels in males. Raising vitamin D levels (a) helps the other ingredients work to their fullest potential and (b) may knock out a potentially causative factor for low testosterone levels in the first place.
But, having said all of that, I understand your frustration, and I'll see what we can do for you. I know that we're going to start work on a new batch of product next week. It may be possible for our production facility to bottle a few units before the vitamins D and K are added into the mix. If we can, and if you don't mind waiting a couple of weeks, we should be able to get those vitamin-free bottles over to you. If you're interested, PM me.
THIS is what I call customer service
THIS is what I call customer service
Yeah...absolutely unreal!Customer service at its best
Very limited so far...I know it’s still early... but- any other feedback on this stuff?
I know it’s still early... but- any other feedback on this stuff?
Any side effects?
Surely if this works will it need PCT?
Any side effects?
Surely if this works will it need PCT?
Can everyone just relax a bit? I can’t count how many posts I’ve seen with this sentiment. The stuff hasn’t even been shipping for a week yet. That means people that have bought it, who might not even be running it right away because they’re in the middle of other stuff and bought it to take advantage of the intro sale, have had it for a couple of days AT BEST. Exactly what type of feedback could you possibly expect after a couple of days with a test booster? Give it a month before you start asking where the feedback is. You’re just not going to get it right now.
Huh? I’m not looking for an extensive review pal. The main ingredient is rather unexplored... there may be immediate effects.
this would work by stimulating endogenous testosterone production, one could almost think of this AS pct (in a way)
Surely if it does what it says it does we’re going to get side effects
Interesting...4th day on ultra test. It may be placebo but i'm feeling all around better in and out of the gym. I'm on a cut and i feel like my strength is hanging in there a bit better than before. Libido is increasing... I got 3 bottles of this stuff. Excited to see what i feel like in another two weeks or so.
Surely if it does what it says it does we’re going to get side effects
Some more info from the manufacturer:
"The core ingredient is Geranylgeraniol. This is a terpene which is ubiquitous in nature and vital to animal life, but it is everywhere in trace amounts, so it was extremely difficult to isolate and extract.
Geranylgeraniol has been shown, in several recent papers out of Japan, to increase testosterone levels in animals to a truly remarkable extent -- in fact, to such an extent that animals receiving geranylgeraniol saw their testosterone levels double. This can be attributed to the following mechanism of action: Geranylgeraniol potently increases cyclic AMP (cAMP) levels, which then activate the cAMP-dependent protein kinase (PKA), which then boosts mRNA and protein levels of steroidogenic acute regulatory protein (StAR)... and StAR is the rate-limiting gatekeeper of steroid biosynthesis in Leydig cells.
It's worth mentioning that boosting cAMP/PKA can also induce a wide variety of other effects which have, in themselves, little to do with enhanced testosterone biosynthesis -- and that all of these additional effects are positive. They include enhanced fatty acid oxidation, enhanced muscle glycogen synthesis, and vasodilation.
It may be tempting to compare geranylgeraniol to forskolin -- another known PKA-boosting substance -- but forskolin has essentially zero oral bioavailability, and its use is primarily associated with GI distress, whereas geranylgeraniol is very well absorbed, has good oral bioavailability, and won't induce uncomfortable side effects at any dose.
Geranylgeraniol is, for good reason, the core ingredient in Ultratest."
I ordered a single bottle to try out and use while the test subject cycles off Provi. Starting day 2 so hopefully will have more info in a couple of days.
Grondi
So I may step aside on reporting on Ultra Test... I forgot my doc had me start up on DHEA and I fear that will skew any results I think I might be getting.
I will say that after each 1ml dose of U/T, I notice I get a little sleepy for an hour so after ingesting. Seems to be pretty consistent after each dose.
My .01 worth.
Grondi