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We just released a new product TOTAL FOCUS with Zynamite, and I understand there's a lot of questions about the ingredient; what it does, and how it works - so here's a write-up that might help you out.
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ZYNAMITE IS NOW AVAILABLE AS A STANDALONE OR IN TOTAL FOCUS. CLICK HERE TO GET YOURS.
The Definitive Guide to Zynamite (Mangiferin): The Next (Superior) Caffeine Replacement?
ORIGINALLY PUBLISHED BY AZOTH ON: https://medium.com/azoth/the-definitive-guide-to-zynamite-mangiferin-the-next-superior-caffeine-replacement-9309d67b6bd1
Society runs on caffeine.
It’s in our coffee, pre workout, and energy drinks.
Caffeine is even working its way into other “functional foods” like protein powders and peanut butter.
And, make no mistake, I enjoy my caffeine (and in a multitude of ways).
But, not everyone reacts well to caffeine, or can handle the ever-increasing doses that are working their way into dietary supplements and energy drinks.
As a result, a number of caffeine alternatives have been investigated over the years, with some being a bit more “effective” than others.
Notable examples of these caffeine alternatives include TeaCrine and Dynamine, both of which you’ve heard me talk about before.
Today, we’re going to cover another intriguing new caffeine alternative/replacement/synergist is Zynamite®.
WHAT IS ZYNAMITE®?
Zynamite® is a patent-pending proprietary extract of Mangifera indica (mango) standardized to 60% mangiferin.[1]
To date, Zynamite® has been the subject of seven clinical studies and noted for both its nootropic and sports performance benefits.
More on Mangifera indica (Mango)
Mangifera indica has long been used in ayurvedic medicine for a wide variety of ailments due to its antiseptic, astringent, diaphoretic (inducing perspiration — “sweat”), stomachic (improves appetite or digestion), vermifuge (anti-parasitic), tonic, diuretic, and laxative properties.[2]
As a result, various parts of the plant have been used as a remedy for anaemia, asthma, bronchitis, cough, dysentery, hypertension, insomnia, rheumatism, and toothache.
The plant have also been used to treat stings, snakebites, abscesses, blisters, wonds, diarrhea, colic, liver disorders, excessive urination, tetanus and asthma.[2]
Mangiferin, the “Magic” in Mango
Mangiferin is the primary active compound in mangifera indica, found in the leaves, bark, fruit and roots. It can also be found in several other plants, including Salacia chinensis, Swertia chirata, and Hypericum aucheri.[3]
Fig. 1: Structure of Mangiferin[24]
It is a xanthone glycoside, possessing strong antioxidant, antidiabetic, hypotensive, anti-lipid peroxidation, immunomodulatory, cardiotonic, wound healing, and anti-degenerative activities.[2]
Mangiferin is also considered to be a “super antioxidant” capable of specifically protecting against free radical production via the Fenton reaction due to its iron-chelating properties.
Moreover, mangiferin can cross the blood-brain barrier and modulate neurotransmission, K+ channels and nociception.
HOW DOES ZYNAMITE® WORK?
Zynamite® is a catechol-o-methyltransferase (COMT) inhibitor that activates brain waves and increases Long-Term Potentiation (LTP) in a manner similar to caffeine.[21]
COMT is the enzyme that metabolizes neurotransmitters and catecholamines, including dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). It also metabolizes levodopa (L-Dopa), the direct precursor to dopamine.
By inhibiting COMT, the bioavailability of L-Dopa is significantly increased, promoting stronger, longer-lasting dopamine and norepinephrine levels in the central nervous system.
FYI, pharmaceutical-grade COMT inhibitors are also used alongside carbidopa-levodopa therapy in the treatment of symptoms of Parkinson’s disease.
Long-Term Potentiation can be thought of as the “strengthening” of synaptic connections between neurons, which benefit both space and time dependent memory.
While caffeine boosts feelings of energy, mood, and alertness via antagonism of adenosine receptors, Zynamite® acts non-selectively to modulate various CNS targets and stimulate brain activity.[1]
Animal studies note that a dose of 25 mg/kg of Zynamite® attenuates alpha2 and beta1 spectral frequencies in the brain during the first hour after administration, indicating that Zynamite has a fairly quick onset of action (again, similar to caffeine).
Additionally the pattern of frequency changes induced by Zynamite administration mimics those observed following administration of caffeine.
Fig. 8: Direct comparison of the frequency changes observed in the presence of Zynamite® and caffeine alone and in the presence of the combinations during the second hour after administration. Frequency ranges are depicted as coloured bar graphs on the abscissa representing delta (red), theta (orange), alpha1 (yellow), alpha2 (green), beta1a (light blue) and beta1b (dark blue) and gamma spectral power (violet) from left to right within the four brain areas as mentioned on top of the graph. Statistical significance in comparison to control (vehicle) is documented by stars: * = p < 0.10; ** = p < 0.05; *** = p < 0.01.[1]
Interestingly, you’ll notice that when Zynamite and caffeine are combined, there is a synergistic and additive effect on brain waves (but, more on that in a bit).
Based on the data, researchers suggest that at least part of Zynamite’s stimulating properties are due to activation of dopamine, since alpha2 waves are under the control of dopamine.
Researchers also noted a sustained attenuation of alpha1 spectral power during their testing, which can be interpreted as a higher state of wakefulness.
In case you were curious, Alpha1 waves are under the control of the neurotransmitter serotonin.
----
ZYNAMITE IS NOW AVAILABLE AS A STANDALONE OR IN TOTAL FOCUS. CLICK HERE TO GET YOURS.
The Definitive Guide to Zynamite (Mangiferin): The Next (Superior) Caffeine Replacement?
ORIGINALLY PUBLISHED BY AZOTH ON: https://medium.com/azoth/the-definitive-guide-to-zynamite-mangiferin-the-next-superior-caffeine-replacement-9309d67b6bd1
Society runs on caffeine.
It’s in our coffee, pre workout, and energy drinks.
Caffeine is even working its way into other “functional foods” like protein powders and peanut butter.
And, make no mistake, I enjoy my caffeine (and in a multitude of ways).
But, not everyone reacts well to caffeine, or can handle the ever-increasing doses that are working their way into dietary supplements and energy drinks.
As a result, a number of caffeine alternatives have been investigated over the years, with some being a bit more “effective” than others.
Notable examples of these caffeine alternatives include TeaCrine and Dynamine, both of which you’ve heard me talk about before.
Today, we’re going to cover another intriguing new caffeine alternative/replacement/synergist is Zynamite®.
WHAT IS ZYNAMITE®?
Zynamite® is a patent-pending proprietary extract of Mangifera indica (mango) standardized to 60% mangiferin.[1]
To date, Zynamite® has been the subject of seven clinical studies and noted for both its nootropic and sports performance benefits.
More on Mangifera indica (Mango)
Mangifera indica has long been used in ayurvedic medicine for a wide variety of ailments due to its antiseptic, astringent, diaphoretic (inducing perspiration — “sweat”), stomachic (improves appetite or digestion), vermifuge (anti-parasitic), tonic, diuretic, and laxative properties.[2]
As a result, various parts of the plant have been used as a remedy for anaemia, asthma, bronchitis, cough, dysentery, hypertension, insomnia, rheumatism, and toothache.
The plant have also been used to treat stings, snakebites, abscesses, blisters, wonds, diarrhea, colic, liver disorders, excessive urination, tetanus and asthma.[2]
Mangiferin, the “Magic” in Mango
Mangiferin is the primary active compound in mangifera indica, found in the leaves, bark, fruit and roots. It can also be found in several other plants, including Salacia chinensis, Swertia chirata, and Hypericum aucheri.[3]
Fig. 1: Structure of Mangiferin[24]
It is a xanthone glycoside, possessing strong antioxidant, antidiabetic, hypotensive, anti-lipid peroxidation, immunomodulatory, cardiotonic, wound healing, and anti-degenerative activities.[2]
Mangiferin is also considered to be a “super antioxidant” capable of specifically protecting against free radical production via the Fenton reaction due to its iron-chelating properties.
Moreover, mangiferin can cross the blood-brain barrier and modulate neurotransmission, K+ channels and nociception.
HOW DOES ZYNAMITE® WORK?
Zynamite® is a catechol-o-methyltransferase (COMT) inhibitor that activates brain waves and increases Long-Term Potentiation (LTP) in a manner similar to caffeine.[21]
COMT is the enzyme that metabolizes neurotransmitters and catecholamines, including dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). It also metabolizes levodopa (L-Dopa), the direct precursor to dopamine.
By inhibiting COMT, the bioavailability of L-Dopa is significantly increased, promoting stronger, longer-lasting dopamine and norepinephrine levels in the central nervous system.
FYI, pharmaceutical-grade COMT inhibitors are also used alongside carbidopa-levodopa therapy in the treatment of symptoms of Parkinson’s disease.
Long-Term Potentiation can be thought of as the “strengthening” of synaptic connections between neurons, which benefit both space and time dependent memory.
While caffeine boosts feelings of energy, mood, and alertness via antagonism of adenosine receptors, Zynamite® acts non-selectively to modulate various CNS targets and stimulate brain activity.[1]
Animal studies note that a dose of 25 mg/kg of Zynamite® attenuates alpha2 and beta1 spectral frequencies in the brain during the first hour after administration, indicating that Zynamite has a fairly quick onset of action (again, similar to caffeine).
Additionally the pattern of frequency changes induced by Zynamite administration mimics those observed following administration of caffeine.
Fig. 8: Direct comparison of the frequency changes observed in the presence of Zynamite® and caffeine alone and in the presence of the combinations during the second hour after administration. Frequency ranges are depicted as coloured bar graphs on the abscissa representing delta (red), theta (orange), alpha1 (yellow), alpha2 (green), beta1a (light blue) and beta1b (dark blue) and gamma spectral power (violet) from left to right within the four brain areas as mentioned on top of the graph. Statistical significance in comparison to control (vehicle) is documented by stars: * = p < 0.10; ** = p < 0.05; *** = p < 0.01.[1]
Interestingly, you’ll notice that when Zynamite and caffeine are combined, there is a synergistic and additive effect on brain waves (but, more on that in a bit).
Based on the data, researchers suggest that at least part of Zynamite’s stimulating properties are due to activation of dopamine, since alpha2 waves are under the control of dopamine.
Researchers also noted a sustained attenuation of alpha1 spectral power during their testing, which can be interpreted as a higher state of wakefulness.
In case you were curious, Alpha1 waves are under the control of the neurotransmitter serotonin.
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