I don't think Curcumin or its metabolites are inhibiting androgen receptors in healthy tissue but I did see it suggested that this may be the case in cancer tissue.
"Curcumin analogues may facilitate degradation of androgen receptor (AR)
in prostate cancer [
17], "
My thinking is that if curcumin were acting as an androgen inhibitor we would see at least some finasteride-like side effects. I think androgens are being allowed to bind in healthy tissues but the curcumin ( or metabolites thereof) is preventing that tissue from having a negative response to that binding,
"Curcumin shows suppressive effect on HIF1a [
19,
20], which was suggested as a key molecule for transition from prostatitis to BPH [
21]. Moreover, it was proven to be a potent TNF blocker [
7], and its antioxidant effect may suppress LOX1 [
22]. Administration of curcumin was investigated as liposomal-formulated curcumin in Parkinson’s disease (PD) [
11], and lecithinized curcumin delivery system in BPH [
23]. "
Background Benign prostatic hyperplasia (BPH) is one of the common male diseases, which is provoked by dihydrotestosterone (DHT) and androgen signals. Several studies showed that curcumin has various effects of prevention and treatment to diseases. We investigated whether curcumin may repress...
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