It's definitely something off, I'm very muscular, very low bodyfat, everything is in order. I inject testosterone for trt, and have zero sex drive the first day or two after injection. I've never had physical e2 sides, I've blasted 1000mg test-e per week before and didn't have a single physical side, no gyno whatsoever with an e2 level of 136. Normally it stays around 20. Psychologically is a different story though, raising my e2 makes me EXTREMELY anxious, and ridiculously angry/irritable. I'd kill for a high sex drive that lasts. I've tried AI's, and anastrozole gives me flu like symptoms, dead emotionally, dead dick etc. so frustrating and depressing, dealing with this sh-t for 4 years.