Here is a little on coq10
[FONT=Arial, Helvetica, sans-serif]Coenzyme Q10 is involved in energy production at the cellular level, is vital for sustaining life and is found in greatest abundance in the heart. The heart requires more CoQ10 to provide energy needed to pump blood throughout the body. It is also most sensitive to CoQ10 deficiency. Numerous clinical trials have shown that patients with congestive heart failure have low CoQ10 blood levels. Generally, the worse the heart condition, the lower the CoQ10 level. In addition, studies have shown that when administered orally, CoQ10 is an effective therapeutic agent in the prevention and treatment of heart disease.
Clinical studies have also shown that CoQ10 can treat periodontal disease. CoQ10 is also being investigated in treating cancer, diabetes, neurodegenerative diseases like Parkinson’s, Huntington’s and Alzheimer’s and even immune system disorders including AIDS.
While critics claim that there is insufficient evidence in support of CoQ10, proponents point out to the several hundred studies conducted worldwide during the past 35 years. The multi-center study in Italy where 2,664 heart patients clearly showed an improvement in cardiovascular functions is perhaps the most widely known and most definitive study.
A careful analysis of these studies shows that many of them had serious design flaws and shortcomings – namely low daily Q10 dosage, too short a duration, poor bioavailability of CoQ10 used, subjects with long-standing disease, and so on.
Some contend that if CoQ10 is so effective, why isn’t it more popular in medicine. CoQ10 is widely used in Japan, Europe (particularly Germany) and Israel, but it is still not accepted as an effective complementary therapeutic modality in the U.S. In Japan, the site of the world’s first clinical studies on CoQ and heart failure, CoQ10 is an approved and recognized therapeutic agent. While CoQ10 has been accepted by some cardiologists in the U.S., it is not widely used in conventional medical treatments. Some, like Dr. Peter Langsjoen, MD, FACC, speculate that the problem is not medical or scientific, but rather political and economic. Since CoQ10 is a natural product, it cannot be patented. This leaves no economic incentive for pharmaceutical companies to conduct large (expensive) controlled trials necessary to obtain FDA approval.
While it is easier to recommend a specific dose amount (usually 2 mg per 2.2 lbs. of body weight is recommended), the real issue is the bioavailability of CoQ10 or the amount of CoQ10 that enters the bloodstream, and eventually the tissues.
CoQ10 is a fat soluble compound that is poorly absorbed. While some suggest taking it with fats, and some companies have formulated wafers of CoQ10 with essential fatty acids to improve absorption, the most innovative dosage form is available through Tishcon Corp. Tishcon has the exclusive worldwide rights to the BioSolv™ process that dramatically reduces the particle size of CoQ10 and renders it virtually water soluble (“hydrosoluble”). The BioSolv™ process is used in Tishcon’s Q-Gel® Coenzyme Q10, and is available to professionals under the NutriMedika™ label. Human clinical trials published in peer reviewed journals compared the absorption of Q-Gel® with other dosage forms, and the results indicate that Q-Gel® is up to three times more bioavailable than all the other products tested. This breakthrough makes CoQ10 treatment more affordable and more effective. Patients need to take less CoQ10 to obtain optimum blood levels. Compliance is greater as patients experience the benefits in less time.
There have been only a few minor reports of any side effects using CoQ10. These include complaints of having too much energy, diarrhea or nausea. Those experiencing such mild side effects are less than 1% of all those who participated in human clinical trials. Since CoQ10 has been shown to be effective in treating cardiovascular disease as well as other age-related diseases, the popularity of CoQ10 is likely to grow as more baby boomers enter their golden years.
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