I am Vforcer2 on the Mesorx forums.
Before I started the subq shots I had tried creams, IM Cyp, and pellets. I never had any E2 problems with those methods.
When I started the subq shots with 50mg E3D everything was fine for about a month to six weeks. I then blood tested and my T levels were in the 900 range and my E2 was high so I backed off to 42 or 44 mgs(can't remember)to try to get down around 750-800 TT. Not long after I started getting SERIOUS acne(indicating high e2) and breast tenderness(I sound like my wife), so I backed down again to 36mg. When that still did not resolve the problem I started extending a day or 2 before my next shot. I then ordered some liquidex and started taking it at .25 mg twice per week.
I finally gave up on trying to tweak this protocol as it clearly was not meant to be for me.
Tom at Solutions Pharmacy, whom knows Shippen, warned me in the beginning and told me that the release rate for subq is FASTER, NOT SLOWER than IM (Phil said he was wrong) and that it would cause my T levels to spike. I finally surmised he must be correct because of my inability to control the E2. I also had serious hair shedding while on subq.
I went back to 1600mgs of fused pellets and am once again a happy camper.