Ok, well heres what I understand so far after research.
SHBG can be good and bad. Ideally we all want a lower SHBG so that or total testosterone and all hormones are the most bioavailable. However, SHBG is responsible for how long and sustained the hormones are in your body. This must explain why the doctor advised to take 150mg morning and 150mg at night because I felt like my T was wearing off by night time.
I'm also understanding that low SHBG is a sign of insulin insensativity or oversensative insulin reponse. It seems that my SHBG is not too low to the point of serious concern. My blood glucose levels are always fine. My TSH was 1.6, my T3 was at the very top of the range. Earlier when I was on clomid for 10 weeks my SHBG shot up to the 30's.
My doc suggested that I because my SHBG is on the lower end I simply need to dose more frequently as I may metabolize hormones faster. I guess this is why some are suggesting that patients with low SHBG need to have much lower E2 levels as the estrogen is more bioavailable??
Before TRT my E2 was always extremely low, like single digits...and my TT was low like 300ng/dl. However, I still had a decent sex drive and energy to get through life. Most people with levels that low would have serious noticable issues. This must be because my SHBG is low.
You're certainly down the right path in terms of the interplay, and it's good that you took the time to educate yourself.
But we dont all want low SHBG. We want it in the middle. And when are T, DHT, and E2 levels get higher, we want it even higher. You'll be good on the E2 side, as long as you don't take it much lower (given that SHGB will go lower). On the T side, the bioavailability of the T and the DHT could cause some problems if your T & DHT go up more, and SHGB and E2 go down even more, making the former even more bioavailable. If you drop that E2 much lower, you could harm your lipid profile and your bone strength. Low E2 is far harder on the body than high E2.
If you want to be in a highly anabolic and androgenic state, you are absolutely right about wanting very low SHGB. But you need to appreciate, E2 and SHGB are normally higher in someone with high DHT and T for a reason. It's protective.
Note, your other numbers, such as thyroid look good now, but that was before having sustained higher hormone levels, which are about to go even higher, and will place you pretty close to someone that is on cycle, albeit not a very potent one. That's fine for a cycle, but not for a lifetime, as I assume you are contemplating.
I don't think you are at any immediate risk (I'm not fear mongering), but I would suggest some caution. Maybe HAN could step in and illuminate things. Dr. Mariano has written some good things on this subject over on Meso.
Hope that helps. Happy playoffs.
P.S. Gutterpump, this is why the Zols can be dangerous, among other reasons, I assume.
