SSRI'S and supps
- Thread starter allday54
- Start date
mr.cooper69
Legend
There are plenty of supplements that you should be cautious with (i.e. yohimbine). Post them here if you're uncertain
J19891
Member
Only one I can think to avoid off hand would be St. John's Wort and possibly mucuna pruriens/L-dopa. STJW is essentially a weak herbal SSRI, and mucuna/L-dopa effects your neurotransmitters as well.
Aleksandar37
Well-known member
Yohimbine and Rauwolscine. Those will directly interfere, but you also need to address why you are taking the SSRI. If it is for depression, fine, but if you are taking it for anxiety, you might want to stay away from things like stims that will exacerbate your symptoms without actually interacting with your medication.
bdcc
Legend
allday54, if there is anything you are unsure of in regards to interactions, Aleks is the man to ask!
RecompMan
Well-known member
Invalid Link Removed
2 dietary ingredients affecting 5-htt,
5-htt backround on diabetes.. showing that 5-htt increases can aid in serotonin resistance ect.
Major depression as a disorder of serotonin resistance: inference from diabetes mellitus type II
the association between antidepressant use and disturbances in glucose homeostasis; evidence from spontaneous reports
2 dietary ingredients affecting 5-htt,
5-htt backround on diabetes.. showing that 5-htt increases can aid in serotonin resistance ect.
Major depression as a disorder of serotonin resistance: inference from diabetes mellitus type II
the association between antidepressant use and disturbances in glucose homeostasis; evidence from spontaneous reports
Aleksandar37
Well-known member
Under normal circumstances, serotonin is released into the synapse between two neurons and then taken back up. If you have a problem (often depression or anxiety) that might require a boost in serotonin, then SSRIs simply inhibit the presynaptic neuron from taking it back up, so that it has more time to work on the targeted cell. But then if you add something like yohimbine or rauwolscine, which can act on serotonin receptors (you might see them listed as 5-HT receptors), you're going to have too much and could go into the region of experiencing serotonin syndrome. The syndrome itself can be fatal, but, with an SSRI and a supplement, more than likely you're just going to have headaches and nausea.
Those are just two examples of ones that act directly though and the CNS is not that black and white. If you change levels of another neurotransmitter, that may also boost serotonin indirectly, but probably not enough to cause sickness (at least not with supplements).
Aleksandar37
Well-known member
Excellent! Some people are more sensitive to stims than others and pre-workouts should be fine for most. It's when you get into the stim supps that are meant more as fat burners that you might or might not have increased anxiety.
mr.cooper69
Legend
Aleksander hit the nail on the head. Chances are the if you're using SSRIs, you're using them for a reason that yohimbine definitely works against.
mr.cooper69
Legend
Yes
schroedes
Active member
i take 100mg zoloft a day, i know with the androseries products it can be a problem cause of the grapefruit content, what about the new alpha series from FRL?, uses berberine to inhibit cyp34a, think this would increase blood levels of the medication? would like to try the stuff
Aleksandar37
Well-known member
It's a lot to list, but here is what you get from searching over at nutraplanet: Invalid Link Removed
Some of those that are listed don't have yohimbine, but do contain rauwolscine, which is a stereoisomer of yohimbine. One of those products is Alpha-T2. That is why I recommend Shift instead to people using SSRIs.
Aleksandar37
Well-known member
I wouldn't use them together. I recommend asking your pharmacist though.
schroedes
Active member
guys have said they used the androseries with ssri's with no problems, took the meds as far as possible from the supp, too bad a FRL rep couldnt chime in on this and the inhibition of the enzyme. ive also read that zoloft and a couple others arent strongly affected by the cyp34a enzyme anyways so maybe it wouldnt be a problem
Mrpersinality
Member
lboston said:
How is the Lexapro with labido? I got off of Zoloft (hell coming off of that ****) for anxiety but it's coming back big time so i was gonna see about Lexapro
Aleksandar37
Well-known member
There are some meds that are affected more than others. If you were taking something like Buspar, I would say don't mess with it, but you might be fine with the Zoloft. It's just at your own risk of course.
Aleksandar37
Well-known member
10mg is a fairly low dose and pre-workouts for the most part are not going to directly conflict with the Lexapro. My point was that if you're taking it for anxiety, something like a stim which raises your heart rate may trigger a panic attack in some people, but not all. If you're fine though, then keep doing what you're doing
Aleksandar37
Well-known member
The research isn't very clear on a direct connection between the two. The topic does come up because SSRIs can cause sexual dysfunction, which can be an indirect measure of test levels, but not always. If you're not experiencing any issues with libido or erections, I wouldn't worry about it.