[SPONSORED] Supreme Labs USA Tada Drive (tadalafil) citrate/Cialis)

StarScream66

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So, Supreme Labs was kind enough to send me a bottle of their 30mg/ml liquid Cialis product. It's called TADA Drive and it has 30 doses in the bottle.




They also sell it in capsules if you prefer.

Cialis is an erectile dysfunction (ED) drug that can help you overcome that problem in bed, due to age, loss of libido, and AAS usage. It's something you don't want to be using all the time as you can become dependent on it. Cialis lasts a whopping 36 hours in the body, so you'll have 1 and a half day to get your groove on.

CLINICAL PHARMACOLOGY
Mechanism Of Action
Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation.

The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The mechanism for reducing BPH symptoms has not been established.

Studies in vitro have demonstrated that tadalafil is a selective inhibitor of PDE5. PDE5 is found in the smooth muscle of the corpus cavernosum, prostate, and bladder as well as in vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas.

In vitro studies have shown that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. These studies have shown that tadalafil is >10,000-fold more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7 enzymes, which are found in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle, and other organs. Tadalafil is >10,000-fold more potent for PDE5 than for PDE3, an enzyme found in the heart and blood vessels. Additionally, tadalafil is 700-fold more potent for PDE5 than for PDE6, which is found in the retina and is responsible for phototransduction. Tadalafil is >9,000-fold more potent for PDE5 than for PDE8, PDE9, and PDE10. Tadalafil is 14-fold more potent for PDE5 than for PDE11A1 and 40-fold more potent for PDE5 than for PDE11A4, two of the four known forms of PDE11. PDE11 is an enzyme found in human prostate, testes, skeletal muscle and in other tissues (e.g., adrenal cortex). In vitro, tadalafil inhibits human recombinant PDE11A1 and, to a lesser degree, PDE11A4 activities at concentrations within the therapeutic range. The physiological role and clinical consequence of PDE11 inhibition in humans have not been defined.
https://www.rxlist.com/cialis-drug.htm#clinpharm


TL;DR
Tadalafil is a PDE5 inhibitor which increases blood flow to the penis with sexual arousal.[2] It also dilates blood vessels in the lungs, which lowers the pulmonary artery pressure.[2]


...
Mechanism of action[edit]
Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells. cGMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.

The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5. However, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil's inhibition of PDE5 will have no effect without direct sexual stimulation of the penis.

Duration of action[edit]
Although sildenafil, vardenafil, and tadalafil all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.5 hours),[11] compared to sildenafil and vardenafil, which are both 4–5 hours.[12] This translates to a longer duration of action, which is partly responsible for "The Weekend Pill" nickname. Furthermore, the longer half-life is the basis for tadalafil's daily therapeutic use in treating pulmonary arterial hypertension.

Comparison with actions of other PDE5 inhibitors[edit]
Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 enzyme, but these drugs also inhibit PDE enzymes 6, 1, and 11 in varying degrees.

Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil.[13] Some sildenafil users see a bluish tinge and have a heightened sensitivity to light because of PDE6 inhibition.[14]

Sildenafil and vardenafil also inhibit PDE1 more than tadalafil.[13] PDE1 is found in the brain, heart, and vascular smooth muscle.[13] It is thought that the inhibition of PDE1 by sildenafil and vardenafil leads to vasodilation, flushing, and tachycardia.[13]

Tadalafil inhibits PDE11 more than sildenafil or vardenafil.[13] PDE11 is expressed in skeletal muscle, the prostate, the liver, the kidney, the pituitary gland, and the testes.[13] The effects on the body of inhibiting PDE11 are not known.[13]
Source

Here's an excellent article from the Life Extension Foundation on ED and some of it's pharmacological treatments, as well as natural ones.

Interesting, as we all probably know Cialis increase NO2 levels in the body, which you could assume you could get the natural experience with something like arginine and citrulline, but in my experience, although this is a good amino acid combination, it simply doesn't work to produce results for ED. Although arginine and citrulline increase NO2 levels, there is a rate limiting factor in how many enzymes i takes to convert the NO2 to an erection. So, although it might give you a good pump in the gym, it unfortunately won't help give you that same pump in the 'jim'.

Typically, I take my Cialis with yohimbine HCl 2.5mg, which incidentally is sold as it's own erectile aid called Aphrodyne, along with the original Bulgarian Tribulus, Tribestan. You can read more about the OG Bulgarian Tribestan on their website. I feel it gives me a little bit of a libido boost.

I will be taking TADA alone and with combinations of the above supplements I mentioned and see how the pros and cons are. So, stay tuned to this thread and when I get a chance to try TADA, I'll post about the results I have.
 
cheftepesh1

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In to see this
 
cheftepesh1

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Amazing write up to start.
 
cheftepesh1

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Sounds like it works well.
 
GQdaLEGEND

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nice .. in for some penile pumps

dosing it 30mg/ml ?
i saw the caps .. im kinda glad they make it 5mg would be perfect for those who gets horrible sides from the stuff but at the same time works like a charm.
 
enhanced

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I'll be following.. Interesting that you take yohimbine w/ it.. I may have to try that.
 

Ybcano

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First time ordering. Can anyone advise me on how the ordering process is. Do you get an email with payment options?
 
StarScream66

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I'll post some experiences, once I get the experience to have them. Here's hoping! 🤞
 
StarScream66

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Keep in mind you can become dependent on Cialis, Viagra and the other ED drugs. You have to take a break from it or you can get permanent ED unless you're taking the ED drugs.
 
jgraves31

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Keep in mind you can become dependent on Cialis, Viagra and the other ED drugs. You have to take a break from it or you can get permanent ED unless you're taking the ED drugs.
Do you mind a reference or link to more information about this? I’m not finding a source anywhere.
 
StarScream66

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Do you mind a reference or link to more information about this? I’m not finding a source anywhere.
I really couldn't find much about Cialis, but this is the same concept.


This guy was just an idiot. Always measure your dosages with a oral syringe.



There's probably more about there. Do a search for "viagra overuse can't get an erection" or replace viagra with cialis.
 
hman85

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Wondered about trying them out. Let me know your final results
 
StarScream66

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Wondered about trying them out. Let me know your final results
Results are still working very well. The formula itself looks very clean, and all the powder isn't suspended at the bottom like I've seen some Cialis I've seen in the past. I would highly recommend it.
 

Jstrong20

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Keep in mind you can become dependent on Cialis, Viagra and the other ED drugs. You have to take a break from it or you can get permanent ED unless you're taking the ED drugs.
Some studies actaully show daily use improves elections and cure ed form some even after the drug is stopped.
 
StarScream66

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Some studies actaully show daily use improves elections and cure ed form some even after the drug is stopped.
That seems to be what I found with Cialis. People apparently use it for years with no problem. It's also prescribed for BPH (Benign prostatic hyperplasia) https://en.wikipedia.org/wiki/Benign_prostatic_hyperplasia which is the enlargement of the prostate. Although, they obviously won't prescribe it to you for this, it is one side benefit of the drug that is highly beneficial.

Most of the problems I saw with ED abuse was specific to Viagra.
 
hman85

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Results are still working very well. The formula itself looks very clean, and all the powder isn't suspended at the bottom like I've seen some Cialis I've seen in the past. I would highly recommend it.
What dose are you taking?
 
hman85

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The dosage on the bottle is 30mg/ml,so I just took 1ml to start. Now I'm cutting that in half to15mg with half a ml.
I got some of the 5 mg caps I took two definitely a increase but maybe not what I thought last time i took some it was some other rc on am and I had to take a lot it was underdosed. I ended up taking so much i had no clue how much I actually took but it was serious non stop bones. It was too much lol
 
cheftepesh1

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I usually good pills for easy dosing
 
thebigt

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That seems to be what I found with Cialis. People apparently use it for years with no problem. It's also prescribed for BPH (Benign prostatic hyperplasia) https://en.wikipedia.org/wiki/Benign_prostatic_hyperplasia which is the enlargement of the prostate. Although, they obviously won't prescribe it to you for this, it is one side benefit of the drug that is highly beneficial.

Most of the problems I saw with ED abuse was specific to Viagra.
damned VA doesn't have cialis on formulary, but at my age they had no problem prescribing viagra even though i didn't have ED. i've been getting 12 100mg pills every 3 months for last 6 years, i split them into quarters and get 4 uses out of each pill.

no issues when i don't take even after this long-i have 4 bottles of the real blue pills[before they switched to generic] i haven't even used...i think the study might be dose dependent say taking 100mg 2-3 times a week?
 

trumac

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How did this go? Pictures of before and after would be helpful
 

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