SNS MitoBurn

[Irishobrien]

SNS/Steve:

love MitoBurn, but have you seen this?

https://www.sciencedirect.com/science/article/pii/S0006291X24012750?via%3Dihub

“In this study, we introduce Oct-B, a novel BAIBA ester compound, which exhibits 80-fold greater efficacy than L-BAIBA in alleviating obesity”

“The qRT-PCR results indicated Oct-B alleviates obesity by downregulating lipogenic genes (PPARγ, ACC1, FAS), upregulating lipolysis related genes (PPARα, HSL) and thermogenic gene UCP1. Additionally, quantitative mass spectrometry reveals a marked increase in L-BAIBA levels in white fat, brown fat, serum, and muscle following Oct-B administration. These findings suggest that Oct-B is an efficient L-BAIBA substitute, offering a promising therapeutic approach for preventing and treating high-fat diet-induced obesity.”

Looks like synthesis would be relatively easy.

 

[zaareleq]

In for the ride on this

 

[djbombsquad]

Nice find. How do we get this ?

 

[NutButter]

Count me in for some SNS Oct-B XT

 

[sns8778]

SNS/Steve:

love MitoBurn, but have you seen this?

https://www.sciencedirect.com/science/article/pii/S0006291X24012750?via%3Dihub

“In this study, we introduce Oct-B, a novel BAIBA ester compound, which exhibits 80-fold greater efficacy than L-BAIBA in alleviating obesity”

“The qRT-PCR results indicated Oct-B alleviates obesity by downregulating lipogenic genes (PPARγ, ACC1, FAS), upregulating lipolysis related genes (PPARα, HSL) and thermogenic gene UCP1. Additionally, quantitative mass spectrometry reveals a marked increase in L-BAIBA levels in white fat, brown fat, serum, and muscle following Oct-B administration. These findings suggest that Oct-B is an efficient L-BAIBA substitute, offering a promising therapeutic approach for preventing and treating high-fat diet-induced obesity.”

Looks like synthesis would be relatively easy.

Thank you. Sorry it took me a couple days to see it.

I had seen it mentioned, but hadn't seen the full text. Thank you for the link.

I'll look into this and check around and see if anyone is working on it on the raw side and if not, how hard they would expect it to be.

 

[megadeth]

Discussed this with Patrick Arnold a few months ago. He said "reading the article it appears the ester syntheses are laborious and use some pretty toxic reagents. So its not practical unfortunately".

 

[sns8778]

Discussed this with Patrick Arnold a few months ago. He said "reading the article it appears the ester syntheses are laborious and use some pretty toxic reagents. So its not practical unfortunately".

In context, I could imagine it would be very difficult in a private lab setting like his, but it may be a lot easier for larger suppliers to do. Maybe, maybe not, but I know some things can be easier on a small scale but some things can be much harder. I'll be curious to find out.