So leanGLP is also going to help with hangovers........
I had mentioned that DHM, the ingredient you were referring to for hangovers, is an example of an ingredient that is so good at one thing that people stereotype it without realizing how good it is for others, but that luckily researchers didn't, and have done a great deal of research on it.
Here is the DHM information from post #4 in the Lean GLP intro thread:
https://anabolicminds.com/community...ultimate-glp-1-supplement-has-arrived.339058/
Dihydromyricetin (DHM):
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Dihydromyricetin (DHM) is a flavonoid found primarily in the Japanese raisin tree. DHM has been extensively studied for its ability to support liver health, improve alcohol metabolism, and more recently, its potential to boost GLP-1 levels.
DHM has been shown in studies to support fat loss and improved metabolic health via:
- Increasing GLP-1 Levels: Dihydromyricetin has been shown to both stimulate production of GLP-1 and to prolong its lifespan by decreasing the activity of DPP-4, the enzyme that breaks down GLP-1. This means that DHM both promotes GLP-1 secretion and protects it from degradation. A very exciting aspect of this is that DHM has been shown to do this both in vivo (within a living organism) and in vitro (in a laboratory setting).
- DPP-4 Inhibition: Research indicates that dihydromyricetin inhibits DPP-4, the enzyme that breaks down GLP-1.
- Promoting Insulin Sensitivity: Dihydromyricetin has been shown to improve insulin sensitivity, which is important for blood sugar regulation and preventing fat storage. By helping to enhance the body’s ability to use insulin more efficiently, DHM may help make sure that glucose is burned as energy rather than stored as fat.
- Increasing Fat Oxidation: Dihydromyricetin has been shown to activate AMPK, a key regulator of lipid metabolism, which promotes the breakdown of fatty acids and their utilization for energy production. DHM can potentially help reduce body fat by enhancing fatty acid oxidation and promoting the browning of white adipose tissue, essentially turning it into more metabolically active "brown fat" that burns calories more readily.
- Healthy Blood Sugar Levels: Dihydromyricetin has been shown to reduce blood sugar levels and improve insulin sensitivity. It has been shown to reduce fasting glucose, serum insulin, and glycated hemoglobin levels. It has also been shown to improve insulin resistance in skeletal muscle and in in the liver.
- Reducing Inflammation & Oxidative Stress: Chronic inflammation can hinder weight loss by affecting metabolic processes. DHM’s antioxidant properties may help reduce oxidative stress and inflammation, thereby creating a more ideal environment for fat loss to occur
Dihydromyricetin and GLP-1:
Dihydromyricetin (DHM) has been shown to boost GLP-1 levels. An increase in GLP-1 may translate into satiety (feeling fuller longer), less cravings, improved insulin sensitivity, healthy blood sugar levels, and enhanced fat-burning potential.
Dihydromyricetin has been shown to both stimulate production of GLP-1 and to prolong its lifespan by decreasing the activity of DPP-4, the enzyme that breaks down GLP-1. This means that DHM both promotes GLP-1 secretion and protects it from degradation.
A very exciting aspect of this is that DHM has been shown to stimulate GLP-1 secretion and inhibit DPP-4 activity both in vivo (within a living organism) and in vitro (in a laboratory setting).
Here are some of the ways that DHM is thought to influence GLP-1:
- Stimulates GLP-1 Secretion: Research suggests that DHM directly stimulates the secretion of GLP-1 from intestinal L-cells, the cells responsible for producing GLP-1.
- DPP-4 Inhibition: Studies have shown that DHM can increase GLP-1 levels by decreasing the activity of DPP-4, the enzyme that breaks down GLP-1, thereby prolonging its lifespan.
- Exercise Enhancement: Research suggests that DHM can further enhance the exercise-induced elevation of GLP-1 levels, potentially making it a more potent option for managing blood sugar with physical activity.
- Gut microbiota interaction: Some studies indicate that DHM may increase GLP-1 levels by influencing gut microbiota, primarily by promoting the growth of beneficial bacteria that produce short-chain fatty acids (SCFAs) which then stimulate the L cells to release GLP-1.
In summary, Dihydromyricetin has been shown to support fat loss and improved metabolic health by a number of key pathways and has been shown to both stimulate the secretion of GLP-1 through multiple pathways and also to help protect it from degradation.
DHM is included in Lean GLP for its exciting potential to support healthy blood sugar levels, increase satiety (feelings of fullness), reduced appetite, and improved fat burning.
