The whole point of methylation is bioavailability, otherwise it wouldn't be more than just a factor for increased hepatoxicity. It's not necessary to take with a fatty meal, but it couldn't hurt (although it will likely slow absorption). I would concentrate more on clean carbs with superdrol doses. Sweet potatoes, oats, waxy maize, etc.
As far as dosing, I would take the doseages separately. This should help levels stay more constant and help avoid harsher than necessary sides.
Are you already on cycle or are you still planning everything. What do you have for support supps and pct?