Random thoughts about Ostarine

CatSnake

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In reading through some of the threads lately, it seems like a lot of guys are having some odd effects from Ostarine, namely gyno and erectile dysfunction, even after full PCT's.

now, Ostarine is suppresive to the HPTA. 3 mg has been shown to be moderately suppressive to the HPTA.

http://www.ergo-log.com/enobosarmtrial.html

but it does not aromatize to estrogen or convert to DHT. in fact, the above study shows a significant reduction of estradiol while on cycle.


so how to we get gyno? the only theory I've read there, is that Ostarine lowers SHBG, thereby freeing estrogen to bind to the ER.


and why the ED? my assumption is that it's partially due to a drop in DHT (although the lowered testosterone and E2 levels undoubtedly would affect this as well).


^so, how are these issues managed the most effectively?
 
netflixNchill

netflixNchill

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I think you hit the nail on the head with your presumptions
 
skinnybones

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for the gyno issue, I would make sure to have nolva, ralox or DHT topical cream on-hand to address that if it occurs.
Address the gyno/symptoms with Nolva during or even after pct but what about during the cycle?
 

CatSnake

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Address the gyno/symptoms with Nolva during or even after pct but what about during the cycle?
I'm thinking actually using that on cycle. Ralox might be best, but Nolva should work.... I'd transition to Clomid for PCT, tho.


kind of a weird scenario..... E2 will be lower on Ostarine, so taking an AI will likely crash that to a rather uncomfortable level.
 
jgntyce

jgntyce

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A cycle support such as CEL CYCLE ASSIST and TUDCA is recommended on any cycle that suppresses your system.
 
skinnybones

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I'm thinking actually using that on cycle. Ralox might be best, but Nolva should work.... I'd transition to Clomid for PCT, tho.


kind of a weird scenario..... E2 will be lower on Ostarine, so taking an AI will likely crash that to a rather uncomfortable level.
Cool. I thought that’s what you meant, Nolva “on” cycle but just want to make sure for me and everyone else.
Thanks bro
 
Eight

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Dunno. But my SHBG was through the ****ing roof after an ostarine cycle.

Blood test was a few weeks after I finished, so I guess you could argue that it went up during PCT... But if ostarine had lowered it then that would have been one hell of a rebound to reach twice the "normal" max.
 

CatSnake

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Dunno. But my SHBG was through the ****ing roof after an ostarine cycle.

Blood test was a few weeks after I finished, so I guess you could argue that it went up during PCT... But if ostarine had lowered it then that would have been one hell of a rebound to reach twice the "normal" max.
interesting.... makes me wonder if the SHBG theory is accurate then.

I kinda wondered if the SARM managed to activate the ER somehow, but that seems unlikely....
 
Eight

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interesting.... makes me wonder if the SHBG theory is accurate then.
Or I could just be a freak case.

Prolactin went high during that time too, but other than that I had no issues with that run. Well, aside from not sleeping for two months. :)
 

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