The study was a randomized comparative clinical trial of Noopept and piracetam performed on two groups totaling 53 patients. One group contained 37 patience who were over 50 years old, with central nervous system diseases. The other group contained 16 patients, aged 18-60 years old, with post-tramuatic CNS damage.
To be included in the study, patients had to have a diagnosed cognitive insufficiency, a score not more than 27 points on the MMSE, and no other neurological diseases. They also excluded people with severe dementia, delusions, hallucinations, alcoholics, etc.
The study lasted 56 days, with patients either receiving piracetam 3 times a day or noopept 2 times a day. Out of the 37 patients with CNS disorders, 21 received Noopept (16 received piracetam). Out of the 16 with post-concussional syndrome 10 received not (6 received piracetam).
A total of 41 patients completed their 56-day treatment and most of them experienced decreases in neurosis-like symptoms and cognitive disorders. In the patients with organic emotionally labile (asthenic) disorder of vascular origin, the effects of Noopept were apparent from the first week of treatment, with reductions in irritability and improvements in going to sleep. From the second week of treatment there were reductions in fatigue, listlessness, weakness, tiring, apathy, and daytime drowsiness. From the third week on there were reductions in anxiety, depressed mood, and hyperesthesia. These changes were seen in addition to autonomic-system normalizing that took place, and is consistent with previous data showing that Noopept has anxiolytic and psychostimulatory effects.
For patients with post-concussional syndrome, they also had a positive effect on their irritability, anxiety, and affective lability, as well as with fatigue, weakness, apathy and listlessness. The results in these patients were seen slightly later than in the group with emotionally labile (asthenic) disorder, at 3-4 weeks. Noopept also did not negatively effect their ability to go to sleep, or to the depth and duration of sleep.