It's always suggested to take a break after running a product for 8-12 weeks. It lets your body re-adjust and you won't build up tolerances. That said, if you wanted to run True Shred for longer than suggested I don't see too many negative side effects other than you will likely plateau with results. I still would recommend taking a break after running it 8 to 12 weeks and you won't build up a tolerance to any of the compounds in true shred and should have good progress.