The Birth of Orig1n:
This thread has very Nice and detailed info about this "inovative" and pretty potencial supplement but I will Write a short "story" how actually Orig1n was born.
Japan is well known for their KAMPO medicine (prescription drugs made of Herbs/plants based on ancient Chinese Medicine). Those medicines are actually approved by government and they really do the job!
Tsumura & CO is one of the biggest KAMPO Pharma in Japan and they have plenty of KAMPO medicines for different illness/issues.
One of the most interesting medicines they have is Rikkunsh|to.
RIkkunsh|to is a Japanese prescription drug made of 8 Herbs. It is a Natural oral Ghrelin Secretagogue and is prescribed for many things such as weak digestion, no appetite, fullness and epigastric distress, lack of stamina, anemia, cold hands and feet, gastritis, gastric catarrh, indigestion, stomachache,vomiting and it is actually approved and used by anorexia–cachexia cancer patients! (Anamorelin, MK677 and other Oral ghrelin agonists are made for Anorexia-Cachexia Cancer patients).
So which Herbs/plants does Rikkunsh|to contain:
one dose of Rikkunsh|to extract granules (7.5g) is made of :
1. Atractylodes Lancea Rhizome (4g)
2. Ginseng (4g)
3. Pinellia Tuber (4g)
4. Poria Sclerotium (4g)
5. Jujube (2g)
6. Citrus Unshiu peel (2g)
7. Glycyrrhiza (1g)
8. Ginger (0,5g)
Even its made of Herbs/plants, it is not side effects free. Doctors are carefully monitoring patients when they are on Rikkunsh|to because Rikkunsh|to contain solid dose of Glycyrrhiza (Glycyrrhizinic Acid/Glycyrrhizinates), it has negative impact on Serum Potassium Levels, blood pressure and more.
So Hypokalemia is very likely to occur and it can lead to Myopathy and Pseudoaldosteronism too.
It is effective drug but monitoring by doctor is needed. (bloodWorks etc).
Are all those 8 Herbs/plants increasing Ghrelin ? No, it is actually just 2 compounds in Rikkunsh|to and Patrick Arnold wrote this on his blog:
"Two chemical constituents of Rikkunsh|to proposed to be responsible for these effects are Hesperidin and Atractylodin. Hesperidin is thought to increase Ghrelin secretion via antagonizing a subtype serotonin receptor known as the 5-HT2b/2c receptor. Atractylodin is believed to sensitize the ghrelin receptor, thereby amplifying the physiological effects of the increased ghrelin secreted into the bloodstream"
Rikkunsh|to has Citrus Unshiu Peel (Hesperidin) and Atractylodes Lancea Rhizome (Atractylodin). Those two are responsible for Ghrelin secretion and that is why Orig1n contain those two compounds to give Ghrelin boost which may also secrete GH and IGF1.
Orig1n has Atractylodes Chinesis Koidz oil (containing 20% Atractylodin. Not sure how much Atractylodin it is in Rikkunsh|to) and it has SOLID dose of Hesperidin Methyl Chalcone. (it is more Hesperidin in Orig1n than in Rikkunsh|to).
Personaly, I really love this idea because this is like Rikkunsh|to but containing just those compounds for Ghrelin secretion. We are actually avoiding many sides such as High blood pressure, Hypokalemia and other which would occur With Rikkunsh|to due to Liquorice Root.
This is actually very inovative Product and it has pretty good potencial to be honest! I would run it at least 2 months (longer would be better).
The other very good thing is : Orig1n does not contain any ingredient which need to be cycled off so you can run this pretty long
It does not stop there!
Orig1n also contain Gentian Root. Many who has tried it felt amazing appetite increase. But it is not the only positive thing it does. It also optimalizes Stomach and Gastric juices giving one amazing digestion. we all know how important a good digestion is. Better digestion=better gains due to better nutrient uptake.
Many would say "appetite boost while cutting is bad". But is it? It would be even easier eating pretty clean.
Gentian Root may secrete Ghrelin too. Since it is one of the bitter herbs,it regulate/activate bitter taste receptors (TAS2R) and bitter taste receptors regulate the secretion of ghrelin!
Robuvit is very interesting and I mean this is a Nice add to Orig1n!
Orig1n is really interesting Product and it is potencial Ghrelin secretagogue. I do understand there are many sceptical guys but honestly It is really Worth trying before bashing it