Pregnenolone

rippedintexas said:
.

The docs at the clinic I attend are certified in anti-aging medicine, and they concluded the low DHEA and Pregnenolone were likely responsible for the high SHBG and lower Free T, and the replacement of these should bring up my Free T without the need to go on TRT.

.
Click to expand...

Uggggg:rasp: I really really loath these antiaging clinics. They are full of alot of quackery.

Low DHEA and low Preg is not responsible for high SHBG/lowFT and neither should they be a reason to supplement such compounds. I really do wonder where some of these people get their ideas. Do they just make this stuff up?

The reason we add Preg/Dhea is because any time you start adding in exogenous T your body will cease to make other androgenic hormones. By adding in Preg, which is the mother hormone of all others, you replenish what your body has stopped making becuase of being on HRT.
 
I don't think SHBG is an invalid assay. You're putting words into Dr John's mouth. He said it *can* be unreliable, but I don't ever recall him saying that it was "invalid".

How many times have you had your SHBG checked?

I've had it checked at least 20 times in the last few years. The range has always been from 13-20. So yes, there is some variance and whether or not that variance is what makes it "unreliable" is debatable, but the trend is consistent. (ie, I have SHBG on the low end of normal). Using many SHBG readings though, you can spot a trend.

Also, Dr Shippen's chart to extract "Free T" based on Total T and SHBG is based on you guessed it...Total T and SHBG. It is fair to call the Free T assay invalid. That's why the chart exists. If SHBG is "invalid", then Dr Shippen's chart is trash and I don't think anyone will go there...not even Dr John.

Sonny
 
T800 said:
I don't think SHBG is an invalid assay. You're putting words into Dr John's mouth. He said it *can* be unreliable, but I don't ever recall him saying that it was "invalid".

How many times have you had your SHBG checked?

I've had it checked at least 20 times in the last few years. The range has always been from 13-20. So yes, there is some variance and whether or not that variance is what makes it "unreliable" is debatable, but the trend is consistent. (ie, I have SHBG on the low end of normal). Using many SHBG readings though, you can spot a trend.

Also, Dr Shippen's chart to extract "Free T" based on Total T and SHBG is based on you guessed it...Total T and SHBG. It is fair to call the Free T assay invalid. That's why the chart exists. If SHBG is "invalid", then Dr Shippen's chart is trash and I don't think anyone will go there...not even Dr John.

Sonny
Click to expand...

"First, limitations in the measurement of TT, SHBG, and particularly direct (analog) FT assays are extracted from the scientific literature and recent external and internal QC reports. It is concluded that the free direct T assay is useless in the clinical context of andropause. The impact of the observed limitations of TT and SHBG measurements on calculated FT and BAT or BAT obtained by precipitation with ammonium sulfate is then discussed. A comparative evaluation of the advantages and disadvantages of calculated FT or BAT vs. precipitated BAT is presented before concluding that doing a TT as a first line test remains overall the most cost-effective measurement in the diagnosis of hypogonadism in males, and that this sole determination will be sufficient in over 75% of the cases. " - Invalid Link Removed
 
I'm not sure what you're trying to say, PC.

I said Free T was a worthless assay. You said SHBG is a worthless assay.


Sonny
 
hardasnails1973 said:
If ft and shbg then how can you measure bioavailable T then?
Click to expand...

Nails,
The more and more I learn, the more and more Im skeptical about all bloodwork, regardless of what we are measuring for. There is so much invalidity. And they only give you a snapshot of levels at that particular point of the day.

For me, Im becomming more and more convinced that Urines are the only way to go to get the very best measurement possible of whats really going on from a hormonal standpoint.
 
HAN: You need SHBG and Total T for the Free T calculator that Dr Shippen uses. Hence my point that SHBG can't be a totally worthless (inconsistent...maybe) assay.

PC: I think the urines idea certainly has merit. I know Dr John is a proponent of them. I don't know how many of the commonly used blood assays are available via urine or what insurance companies' standpoint is on them. I think that's the roadblock for many. Tests are expensive. My urine neurotransmitter test was about $200 since insurance wouldn't cover them. I have a pretty decent plan, too. Definitely would not want to eat that amount of money on a regular basis!

Sonny
 
plymouth city said:
Nails,
The more and more I learn, the more and more Im skeptical about all bloodwork, regardless of what we are measuring for. There is so much invalidity. And they only give you a snapshot of levels at that particular point of the day.

For me, Im becomming more and more convinced that Urines are the only way to go to get the very best measurement possible of whats really going on from a hormonal standpoint.
Click to expand...

I worry.

I see signs of analysis paralysis.

At one time one need to finish decission making process and take action.

Most decissions are made on incomplete information.

There are no perfect tests, all have some deficiencies.

When better tests become available we will use them, in the mean time what we have to suffice.
 
T800 said:
HAN: You need SHBG and Total T for the Free T calculator that Dr Shippen uses. Hence my point that SHBG can't be a totally worthless (inconsistent...maybe) assay.

PC: I think the urines idea certainly has merit. I know Dr John is a proponent of them. I don't know how many of the commonly used blood assays are available via urine or what insurance companies' standpoint is on them. I think that's the roadblock for many. Tests are expensive. My urine neurotransmitter test was about $200 since insurance wouldn't cover them. I have a pretty decent plan, too. Definitely would not want to eat that amount of money on a regular basis!

Sonny
Click to expand...

Sonny,
Urines are actually cheaper than bloodwork. Your looking at 224 bucks for the panel.

Off the top of my head, the only important ones urines can't measure is IGF and SHBG. I am now of the conclusion that SHBG is pointless anyways. Get T and E in line and let SHBG fall where it may.

IGF is another matter. Because of the very nature of BW being somewhat inaccurate in some tests and completely inaccurate in others, IGF levels have a +- ratio of 30 points usually.

And let us not forget that the important Estrogen by products like 16 hydroxy and others can ONLY be measured in urines.
 
JanSz said:
I worry.

I see signs of analysis paralysis.

At one time one need to finish decission making process and take action.

Most decissions are made on incomplete information.

There are no perfect tests, all have some deficiencies.

When better tests become available we will use them, in the mean time what we have to suffice.
Click to expand...

Agreed, no doubt.
 
plymouth city said:
Sonny,
Urines are actually cheaper than bloodwork. Your looking at 224 bucks for the panel.

Off the top of my head, the only important ones urines can't measure is IGF and SHBG.
Click to expand...

Don't oversell the urines - they test a lot, but primarily only steroid hormones. At Rhein, for an additional fee, you can get fT3 and fT4. All the ancillary (but necessary) tests such as CBC, chem, liver, LH, FSH, SHBG, PSA, prolactin, IGF-1, lipids, homocysteine, CRP etc. have to be done w/ BW.

And yes, that's true--not all patients need all of those tests. But anybody is going to need at least a minimal amount of blood work that will cost at least what the 24 hour UA costs.

For an initial visit, you are looking at at least $500 for labs, probably more. Initial followup is about the same. Later followups cost less, unless things aren't going well.
Dr. John likes followups every 6 mos.
 
plymouth city said:
Uggggg:rasp: I really really loath these antiaging clinics. They are full of alot of quackery.

Low DHEA and low Preg is not responsible for high SHBG/lowFT and neither should they be a reason to supplement such compounds. I really do wonder where some of these people get their ideas. Do they just make this stuff up?

The reason we add Preg/Dhea is because any time you start adding in exogenous T your body will cease to make other androgenic hormones. By adding in Preg, which is the mother hormone of all others, you replenish what your body has stopped making becuase of being on HRT.
Click to expand...


I am not on HRT. The question is why are the DHEA and Preg low, regardless of their effects on FT/SHBG. These low levels are occurring for some reason.
 
rippedintexas said:
I am not on HRT. The question is why are the DHEA and Preg low, regardless of their effects on FT/SHBG. These low levels are occurring for some reason.
Click to expand...

It is good to know the reasons.
Because of that medical science makes a progress.
I like to read about arguments and research about reasons why hormones are at this and not the other level.

In a mean time you identified problem,
low DHEA and low pregnenolone.

eventually you should have a better chance a feeling better when you work at bringing thise two numbers up to desired level.

We have noted that supplementing just with pregnenolone raises both (preg and DHEA), so at first try just pregnenolone.

I noted that DHEA and pregnenolone pills do not work much for me. Used about 350mg/day of DHEA with meager results.
Drastically changed with short time on preg cream.

At the moment looks like prescription compounded pregnenolone cream is the way to go.
I use 1gram/day of 100mg/1gram compounded cream.

There are preg creams over the counter, of unknown (and low) amount of pregnenolone in them, waste of time.
 
JanSz said:
It is good to know the reasons.
Because of that medical science makes a progress.
I like to read about arguments and research about reasons why hormones are at this and not the other level.

In a mean time you identified problem,
low DHEA and low pregnenolone.

eventually you should have a better chance a feeling better when you work at bringing thise two numbers up to desired level.

We have noted that supplementing just with pregnenolone raises both (preg and DHEA), so at first try just pregnenolone.

I noted that DHEA and pregnenolone pills do not work much for me. Used about 350mg/day of DHEA with meager results.
Drastically changed with short time on preg cream.

At the moment looks like prescription compounded pregnenolone cream is the way to go.
I use 1gram/day of 100mg/1gram compounded cream.

There are preg creams over the counter, of unknown (and low) amount of pregnenolone in them, waste of time.
Click to expand...

So if one that has a flooded estrogen metabolism who takes hcg and pregenonlone creame with out or simulataneously correcting the imbalance could be asking for BIG trouble because HCG and preg due increase progesterone and would cause greater elevations in estrone and plug up an already alterated pathway adding more fuel to the fire so to speak. So checking estrogen metabolism would be a priority on any TRT to see what modality would be safe and proper at that time. Because I am seeing a few sites starting to recommend DIm with taking progesterone , MACA, and pregenonlone may eb to the chance that it may put strain on estrogen pathyways
 
hardasnails1973 said:
So if one that has a flooded estrogen metabolism who takes hcg and pregenonlone creame with out or simulataneously correcting the imbalance could be asking for BIG trouble because HCG and preg due increase progesterone and would cause greater elevations in estrone and plug up an already alterated pathway adding more fuel to the fire so to speak. So checking estrogen metabolism would be a priority on any TRT to see what modality would be safe and proper at that time. Because I am seeing a few sites starting to recommend DIm with taking progesterone , MACA, and pregenonlone may eb to the chance that it may put strain on estrogen pathyways
Click to expand...

What does the Maca do?
 
wildfox said:
What does the Maca do?
Click to expand...

Maca is supposed to increase load size. A lot of steroid users include it in their PCT for libido. I have not had any luck on it, but I havent tried it since I have been on TRT. I don't think natural test boosters work when you are already shut down such as in TRT, but I could be wrong. I have a lot of bulk herbal stuff in the cabinet (200 grams of Maca included) that I could try and see what the effects are on someone who is on TRT.
 
JanSz said:
It is good to know the reasons.
Because of that medical science makes a progress.
I like to read about arguments and research about reasons why hormones are at this and not the other level.

In a mean time you identified problem,
low DHEA and low pregnenolone.

eventually you should have a better chance a feeling better when you work at bringing thise two numbers up to desired level.

We have noted that supplementing just with pregnenolone raises both (preg and DHEA), so at first try just pregnenolone.

I noted that DHEA and pregnenolone pills do not work much for me. Used about 350mg/day of DHEA with meager results.
Drastically changed with short time on preg cream.

At the moment looks like prescription compounded pregnenolone cream is the way to go.
I use 1gram/day of 100mg/1gram compounded cream.

There are preg creams over the counter, of unknown (and low) amount of pregnenolone in them, waste of time.
Click to expand...

Sounds like a good approach. Interestingly, my DHEA levels dropped below the range before the Preg. DHEA started dropping on previous blood tests while Preg remained stable.

I wonder how to get around the side effects? Start with 10mg of Preg or less and raise the dose cautiously; i.e., the "low and slow" approach that is used for other hormones?
 
rippedintexas said:
Sounds like a good approach. Interestingly, my DHEA levels dropped below the range before the Preg. DHEA started dropping on previous blood tests while Preg remained stable.

I wonder how to get around the side effects? Start with 10mg of Preg or less and raise the dose cautiously; i.e., the "low and slow" approach that is used for other hormones?
Click to expand...

Pregnenolone pills did not worked for me.

Prescription compounded pregnenolone cream is the way I am going.
I use 1gram/day of 100mg/1gram compounded pregnenolone cream.

Use, test, adjust dose, re-test and so on.

No magic pills.
 
rippedintexas said:
I am not on HRT. The question is why are the DHEA and Preg low, regardless of their effects on FT/SHBG. These low levels are occurring for some reason.
Click to expand...

Pregnenolone assay is worthless, discard it.

You are low on DHEA. GIVEN THAT YOU ARE LOW ON DHEA, one can assume one is low on Pregnenolone as well.

You are better off judging how much Pregnenolone you are making based on DHEA score rather than an invalid test like pregnenolone.

DHEA is a top of the hormone tree substance just like pregnenolone.

I would like to note that neither one of these is made within the testes, or has anything to do with testicular functioning.

You should give Dermacrine a try.
 
plymouth city said:
Pregnenolone assay is worthless, discard it.

You are low on DHEA. GIVEN THAT YOU ARE LOW ON DHEA, one can assume one is low on Pregnenolone as well.

You are better off judging how much Pregnenolone you are making based on DHEA score rather than an invalid test like pregnenolone.

DHEA is a top of the hormone tree substance just like pregnenolone.

I would like to note that neither one of these is made within the testes, or has anything to do with testicular functioning.

You should give Dermacrine a try.
Click to expand...

That's why I noted earlier that I likely have some adrenal issues. Thanks for the Dermacrine mention. Looks like a good product.
 
rippedintexas said:
Sounds like a good approach. Interestingly, my DHEA levels dropped below the range before the Preg. DHEA started dropping on previous blood tests while Preg remained stable.

I wonder how to get around the side effects? Start with 10mg of Preg or less and raise the dose cautiously; i.e., the "low and slow" approach that is used for other hormones?
Click to expand...

Sounds like Adrenal Fatigue. I was exactly the same.
 
coz said:
Sounds like Adrenal Fatigue. I was exactly the same.
Click to expand...

Did you ever figure out what caused yours? What symptoms did you mainly have?

Mine is suspected of being caused by a sleep disorder that was only recently diagnosed by a sleep study.
 
rippedintexas said:
Did you ever figure out what caused yours? What symptoms did you mainly have?

Mine is suspected of being caused by a sleep disorder that was only recently diagnosed by a sleep study.
Click to expand...

Hard to say what the exact cause was, could be any or a combination of too much stress, partying to hard, no sleep, quite a few operations, and some heavy sicknesses, low T, low Thyroid etc

Main point is I have it, and am being treated for it by my doc. Time will tell if they can heal themselves with treatment and I can reduce the meds, or if I'll need to take them permanently.
 
I have very low progesterone, DHEA, androstenedione levels. I have adrenal fatigue (serious case -1 yr in bed few weeks of feeling better just to be followed by major setbacks after ingestion of coffee or smoking.)

I m wondering about using pregnenolone, since i used hydrocortisone but it gave me serious Na+ and water retaining problems and ended up in the hospital and 2 months in bed with headaches, intracranial pressure changes, steroid glaucoma etc etc. Doctors told me i shouldnt self medicate, i was however desperate for some energy. Later on i found out that the most probable reason for my hydrocortisone side effects and problems induced was my already high aldosterone levels (weird to have adrenal fatigue with high aldosterone levels yet its true- since mine originate from overtraining and noradrenaline excess rather from adrenaline overload and psychological or other stressors accumulation)

Now since i cant take directly hydrocortisone and since i have understood that optimal adrenal function has nothing to do with levels of one hormone or the other but rather the hormone correlation levels i think i need to take the mother of all adrenal steroid hormones, pregnenolone??

I though of taking DHEA but have chronic prostatitis, high dht and dhea i am not sure if it will stabilize my cortisol levels. I know however for a fact that at this point my dhea levels are shunted towards cortisol production.

Man i am a wreck. I am 28 last year at this time i could easily bench 130kg and squat even more. Now i cant get out of bed, my knees are killing me, my blood sugar is out of line, i dont eat nothing but fish and green, i want to smoke and i cant i cant sleep properly, i hate all these sedatives, dont need them but cant sleep without them since my cortisol levels are so low im having problems doing anything.

So if anyone has any feedback on pregnenolone supplementation pls pls pls contact me or write back. I need all info possible.

Im in a country where preg doesnt even exist?? They dont even know of it, how am i supposed to get it?

Plus is oral/ sublingual/ cream better choice and in what amounts and for how long?

Will i be needing preg for the rest of my life or on and off or can i supplement it for some weeks and hope my adrenals will heal ??

Does it have negative feedback on my LH/FSH levels ?? They are already low dont wanna mess this up anymore

Thanks
 
solonjk said:
I have very low progesterone, DHEA, androstenedione levels. I have adrenal fatigue (serious case -1 yr in bed few weeks of feeling better just to be followed by major setbacks after ingestion of coffee or smoking.)

I m wondering about using pregnenolone, since i used hydrocortisone but it gave me serious Na+ and water retaining problems and ended up in the hospital and 2 months in bed with headaches, intracranial pressure changes, steroid glaucoma etc etc. Doctors told me i shouldnt self medicate, i was however desperate for some energy. Later on i found out that the most probable reason for my hydrocortisone side effects and problems induced was my already high aldosterone levels (weird to have adrenal fatigue with high aldosterone levels yet its true- since mine originate from overtraining and noradrenaline excess rather from adrenaline overload and psychological or other stressors accumulation)

Now since i cant take directly hydrocortisone and since i have understood that optimal adrenal function has nothing to do with levels of one hormone or the other but rather the hormone correlation levels i think i need to take the mother of all adrenal steroid hormones, pregnenolone??

I though of taking DHEA but have chronic prostatitis, high dht and dhea i am not sure if it will stabilize my cortisol levels. I know however for a fact that at this point my dhea levels are shunted towards cortisol production.

Man i am a wreck. I am 28 last year at this time i could easily bench 130kg and squat even more. Now i cant get out of bed, my knees are killing me, my blood sugar is out of line, i dont eat nothing but fish and green, i want to smoke and i cant i cant sleep properly, i hate all these sedatives, dont need them but cant sleep without them since my cortisol levels are so low im having problems doing anything.

So if anyone has any feedback on pregnenolone supplementation pls pls pls contact me or write back. I need all info possible.

Im in a country where preg doesnt even exist?? They dont even know of it, how am i supposed to get it?

Plus is oral/ sublingual/ cream better choice and in what amounts and for how long?

Will i be needing preg for the rest of my life or on and off or can i supplement it for some weeks and hope my adrenals will heal ??

Does it have negative feedback on my LH/FSH levels ?? They are already low dont wanna mess this up anymore

Thanks
Click to expand...
Check for Candida.

Eat lots of strong probiotics and digestive enzymes.
Watch your E2 and other estrogens.
 
griffin,
how much PREG do you use per day? who is your doc? did he provide any evidence to you suggesting the benefit of PREG oral vs TD, as in your case he is supplementing you with oral PREG ? Does he offer Rx PREG oral capsules, or do you get these over the counter?

Thanks


griffinannie said:
ITSHECTIC, sorry for the delayed response, I've been out of town. To answer your question, my doc prefers oral to transdermal. The only reason I know is think he believes the oral is more bioavaiable to receptors in the brain. ( I hope I said that right.) I have tried both and can't say that I can tell a difference and since my doc knows a hell of a lot more than me I'm going with him. He seems to be rite on everything else.
Click to expand...
 
BUMP. also, i have been taking 100mg ED pregnenolone oral OTC tablets, and have found a ridiculous increase in energy, also, my appetite seems to be significantly reduced. i have reduced by dose of HCG monotherapy down to 250IU Pregnyl HCG ED because of my additional pregnenolone oral supplementation. i admit myself a skeptic, i would have never dreamed that a simple OTC supplement could have such powerful stimulant like effects?

IMO hcg monotherapy + oral pregnenolone (or TD Rx PREG, i cannot comment because i have not tried this formulation) is the way to go!
 
I can't take pregnenolone oral OTC I do HCG and when I do PREG. it drives up my Estradiol levels makes me feel Panic. I have used PREG before going on HCG and had no problems.

I do my Depo T shot .35 mls every 3 days and I do HCG 400 IU's the 2 days each in between my T shots. Doing this keeps me leveled and holds down my Estradiol levels. I feel some men can't do PREG on HCG.
 
Oral preg raised my progesterone to over 2x above range.

Is TD Preg the same in this respect? And why would oral preg convert so heavily into progesterone? (I was taking 25mg in the am and 25mg in the pm)

If TD Preg does the same thing, then I don't see the point in taking it myself.
 
From what I understand you can't get good labs on PROG. you need to test PREG to tell because I am on HCG my Dr. tests PREG to tell how PROG is doing if PREG is to high I have to back off my HCG dose.
Gutterpump said:
Oral preg raised my progesterone to over 2x above range.

Is TD Preg the same in this respect? And why would oral preg convert so heavily into progesterone? (I was taking 25mg in the am and 25mg in the pm)

If TD Preg does the same thing, then I don't see the point in taking it myself.
Click to expand...
 
Hrm, but high PREG would be ok for me, the high PROG is what worries me. I don't want high PROG in the slightest and would like to raise my DHT as well.

This all occured before TRT. I once tried taking 50-75mg oral PREG daily for several months to see how it may positively impact my hormones. My test did not budge, my dhea didn't budge, but my PROG skyrocketed.

Right now I take test + hcg + dhea only.
 
Dr. John has always side you can't get good labs on PREG you need to test PROG and your high you need to stop taking what ever drove this up. Here is a cut and paste.
In this he is taking about why we sould not take PROG. I know your not taking it. So it might not be a problem but If I were you I would want them levels down.
======================================
[quoting Dr. John Crisler]
Funny, when you take PREG, your PROG may rise, but it doesn't cause feminization. But if you give straight PROG, bad things happen.
__________________
There is not one valid study that proves men should take PROG. And many which prove he should not.

Simple, irrefutable facts:

PROG elevates SHBG
Suppresses the HPTA
Causes gynocomastia
Causes impotence


Gutterpump said:
Hrm, but high PREG would be ok for me, the high PROG is what worries me. I don't want high PROG in the slightest and would like to raise my DHT as well.

This all occured before TRT. I once tried taking 50-75mg oral PREG daily for several months to see how it may positively impact my hormones. My test did not budge, my dhea didn't budge, but my PROG skyrocketed.

Right now I take test + hcg + dhea only.
Click to expand...
 
before TRT when the PREG drove my PROG up:

SHBG was lowish (low normal)
no gyno, not holding water
was on cialis, had some sex drive but troubles 'finishing'
low normal test, low normal FT, bio test in the lower 1/3rd.

I have no idea what the high PROG was doing to me then, but I know it's not good lol. I have to get it tested again because I stopped taking PREG.

Would you say that TD PREG works differently than oral PREG? Someone told me that one type can cause lethary/calmness and the other can be stimulating/cause anxiety. I am just shocked that it had NO effect on T or DHEA levels.
 
I never tried the creams just the pills and they were this Sublingual.
Invalid Link Removed
Like I said it drove up my Estradiol levels and and killed my sex life with high Estradiol levels I could not reach an orgasm so getting this down and keeping it down I got my night time and morning wood back after not having them for over 35 yrs I am 64.

I started having ED problems again and I am on Cialis 20 mgs every 3 days it even stop working. I started getting Heartburn and found out just a few days a go I have a blockage in the main vessel supplying blood to the left side of my heart.

For yrs I have been having trouble breathing off and on and now it's read bad and the ED is bad even taking a pill. So I am going in tomorrow to have this fixed.

I am told I will feel like a new man and I can't wait to be able to go back in the gym and get some exercise.

So if you have all your levels good and still have problems with your sex life check your heart do a stress test the Heart Dr. told me this is a flag going up when you get ED and can't have sex.
 
I've had ED problems off and on since I was a teenager. I have a feeling there must be something else at play....one of my Dr's thinks I may have an autoimmune disorder..getting that checked out soon with a rheumatologist. He thinks it's a connective tissue disorder. Stupid thing is that I am 30 years old and noone has found this before or thought to test me for it. Maybe I am the stupid one for ignoring my health for so long though. :blink:
 
Well never give up keep trying to figuer it out I had ED for 10yrs on TRT never heard of high Estradiol in men. But when I did and tested it I was very high and getting it down fixed many problems I had. ED, Trouble reaching an orgasm, Panic Attacks, bad rashs on the back of my legs, brain fog, sore and hard nipples, looking red on the upper part of my body like I had a sunburn and feeling hot and sweating day and night.

It's never to late to find out whats wrong and fixing it.
 
hardasnails,
are you currently using oral PREG, to ward off of your said depletion of PREG which is caused by HCG use ?

What evidence do you have which suggests that HCG depletes PREG stores ?


thanks

hardasnails1973 said:
Could not have said it better..When hcg is used in TRT it can actually deplete pregenonlone levels

People with thyroid and low cholesterol issues would also benefit greatly from preg
Click to expand...
 
Griffin Annie
What brand of oral PREG do you use ? Can you purchase this variety, whatever it may be, over the counter, or is it still Rx only ?

Thanks


griffinannie said:
ITSHECTIC, sorry for the delayed response, I've been out of town. To answer your question, my doc prefers oral to transdermal. The only reason I know is think he believes the oral is more bioavaiable to receptors in the brain. ( I hope I said that right.) I have tried both and can't say that I can tell a difference and since my doc knows a hell of a lot more than me I'm going with him. He seems to be rite on everything else.
Click to expand...
 
Hyde12 said:
I have been taking ResetAD that has Pregnenolone in it and I have been experiencing a rise in libido. I want to keep using it but I don't want to lower DHT because I usually have low leveles of it. I aslo don't want to give false indication on my next blood test.
Click to expand...

Do you have any problem with your blood pressure rising when taking this ?? I was taking Solaray Adrenal Caps that also had licorice root in it, and that apparently was the culprit. I've been thinking about trying this stuff but am concerned that I'll run into the same problem.
 
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