What is the difference?
NP Wish there was more detailed info, however have not found much more than this...Thanks. That is what I figured. Im glad you cleared things up for me.
Safe compared to what, a bowl of tapioca pudding??So do you think its safe to start using sarms. I know its fairly new as far as still not in phaze 3 fda testing.
i saw the clinical profile on S-4 and was far from impressed....plus i make a point not to listen to the salesman when considering a purchase.Wait a bit and see if BabyBlu keeps posting while running S-4. As long as he does, thats enough for me
I agree. I did not see anything striking about S-4 on paper.i saw the clinical profile on S-4 and was far from impressed....plus i make a point not to listen to the salesman when considering a purchase.
i believe there is a future to SARMs, but i dont think S-4 is it...
On a scale of 1-11 so the effectiveness seems like a 7 out of 11.
lol....on a scale of leprechauns to boll weevils my confusion is a Model T Ford.hmmm. effectiveness? what effect are you judging. Strength, Hypertrophy, Liver Values, HDL/LDL, etc? What are you comparing this to? Test, Deca, Tren, etc?
Pretty general statement, and in itself has no real meaning.
BTW, why "1-11"?!
On a scale of 9 to -5, my confusion level is a 11 here :think:
lol....on a scale of leprechauns to boll weevils my confusion is a Model T Ford.
Second that.i saw the clinical profile on S-4 and was far from impressed....plus i make a point not to listen to the salesman when considering a purchase.
i believe there is a future to SARMs, but i dont think S-4 is it...
Damn, thats pretty intense BB. If things keep up at this pace, pretty soon you may have to change your name to "BabyBluVeins"Last night I noticed a 'new' vein in the lower palm of my hand, under my thumb. Odd.
bb
arent you like 18 or something?Your right. Soon as I can afford it I would love to try it.
I was thinking safe compared to superdrol haladrol pp, epistane etc. Maybe a stack? I still have some HD and PP left and epistane. For a future cycle.
i think he saying at such a young age you shouldnt be f*cking around with hormones.Would you like me to be 18?
My biological age is 16 but I am a lot older than 18.
exactly. too young.i think he saying at such a young age you shouldnt be f*cking around with hormones.
Would you like me to be 18?
My biological age is 16 but I am a lot older than 18.
Dude, you are confusing as hell to have a reasonable conversation on this topic.... You're biological age is 16 and youre close to becoming 25!?! WTF!?!I am around the corner to becomming 25. I don't know how young that is in comparison to 18 years of age but I think thats not to too young and plus I was just curious.
My chronological age is 24 my actual years but I am aging at at a slower rate so the doctor said Im around the age of 16. I think I said it correctly.
S-4 is an easier way of saying:ive read the write up but what exactly is s-4
Selective Androgen Receptor Modulator Treatment Improves Muscle Strength and Body Composition and Prevents Bone Loss in Orchidectomized Rats
The partial agonist activity of a selective androgen receptor modulator (SARM) in the prostate was demonstrated in orchidectomized rats. In the current study, we characterized the full agonist activity of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide (a structurally related SARM referred to in other publications and hereafter as S-4) in skeletal muscle, bone, and pituitary of castrated male rats. Twelve weeks after castration, animals were treated with S-4 (3 or 10 mg/kg), dihydrotestosterone (DHT) (3 mg/kg), or vehicle for 8 wk. S-4 (3 and 10 mg/kg) restored soleus muscle mass and strength and levator ani muscle mass to that seen in intact animals. Similar changes were also observed in DHT-treated (3 mg/kg) animals. Compared with the anabolic effects observed in muscle, DHT (3 mg/kg) stimulated prostate and seminal vesicle weights moire than 2-fold greater than that observed in intact controls, whereas S-4 (3 mg/kg) returned these androgenic organs to only 16 and 17%, respectively, of the control levels. S-4 (3 and 10 mg/kg) and DHT (3 mg/kg) restored castration-induced loss in lean body mass. Furthermore, S-4 treatment caused a significantly larger increase in total body bone mineral density than DHT. S-4 (3 and 10 mg/kg) also demonstrated agonist activity in the pituitary and significantly decreased plasma LH and FSH levels in castrated animals in a dose-dependent manner. In summary, the strong anabolic effects of S-4 in skeletal muscle, bone, and pituitary were achieved with minimal pharmacologic effect in the prostate. The tissue-selective pharmacologic activity of SARMs provides obvious advantages over steroidal androgen therapy and demonstrates the promising therapeutic utility that this new class of drugs may hold.
Ostarine and Andarine are both aryl propionamide analogs. From this writeup it seems that S-4 is a further altered version.Is ostarine S-4 or some other SARM ?
When the idea of trifluoromethylation was utilized by our laboratory to discover novel aryl-propionamide AR agonists, we identified novel and important in vitro SARs for the AR-binding affinity and agonist activity (30, 31), including a para-nitro group in the A-ring, a trifluoromethyl group linked to the chiral carbon (R-isomer), a thio-ether linkage, and a halo or para-N-alkylamido group in the B-ring. When these compounds were tested in vivo, however, no pharmacologic
activity was observed owing to their unfavorable pharmacokinetic properties (32). Further structural modification was made to overcome this problem by changing the thio-ether linkage to an ether bridge, which resulted in the successful discovery of the first member, S-4, of a new series of SARMs
i just dont quite get it....the stuff appears to work just like nandrolone. it provides next to no androgenic support:
(DHT (3 mg/kg) stimulated prostate and seminal vesicle weights moire than 2-fold greater than that observed in intact controls, whereas S-4 (3 mg/kg) returned these androgenic organs to only 16 and 17%
so unless you want to stack it with T or DHT or proviron or masteron or something, you're not going to have much in the way of libido during a cycle...and obviously, all those steroids impact the prostate, so what's the point again?
what question is there?? this product is highly suppressive, period.hopefully the answer of suppression will be answered soon.
there's a distinction you are perhaps not clear on - suppression isnt what kills your libido and makes for a less than pleasant cycle...suppression PLUS subpar androgenicity does that. on a Test E cycle you are virtually completely shut down within 3 weeks....but your libido is great, and you feel fantastic. on, i dunno, epistane, you are also shut down within a few weeks (this is conjecture but likely), but you dont feel it too much, because epi has a pretty solid androgenic potency also (93% of T i believe)....BUT, on a nandrolone, you shutdown quickly but you have no libido, because nandrolone is only 37% as androgenic as T.this still sounds like a good product even with shutdown, as long as it doesnt turn out to be more suppressive than anything we currently have access to.
that "overview" is 100% worthless, IMO.I guess the question is if this stuff is supposed to be theoretically so horrible on the libido then why is GTx claiming SARMS enhance libido: http://www.gtxinc.com/tech/serm.htm
i dont think that's an opinion - it's fact. LH and FSH were in the gutter, which pretty much confirms that it bound to the hypothalamus.Personally I do think this stuff will have a negative effect on HPTA in long term usage or even after a month or so.
bb
this thread was first in my email box. if you think i am either a) somehow scared of you, or b) unable to pose a superior argument to yours every single time i am called upon to do so, then you are either dimmer than i thought or you have poor short-term memory.Its never been confirmed to my knowledge that Ostarine is conclusively S-4.
Funny though that you never responded to my other post. You must love salt the way you stay on my nuts....
bb