This has turned into a "ill just throw a link down and agree with it " thread with hardly any personal experience discussion brought to the table so I'll be unsubbing now.
Ok, here is my anecdote;
I spent a week training fasted when on holiday. I trained first thing in the morning.
I was significantly weaker and felt nauseous every session. My workouts were significantly easier yet I found them harder than the much more rigorous workouts that I would usually put myself through.
In theory if I did them for long enough I should notice some form of adaptation to them. If I was forced to train first thing in the morning due to my work schedule then I would do it but I don't believe fasted training offers any advantage in terms of performance.
I dont think the training is going to impact the bodyfat or weightloss. the overall caloric deficit would be the major factor regarding that. Depletion training (high rep/hypertrophy) training could aid in glyocgen depletion, but who is to say that is really the key factor to fatloss or fatloss for training. We have seen in real life that hypertrophy training while dieting can be a disaster and cause to a ton of muscle loss if one is not training heavy when they do diet. So it is doubtful as much science as we do read i doubt we have one specifically on bodybuilders or that does compare the fed to fasted state for our exact research we are trying to find since most reserach is done in either 1) Rats, 2) overweight subjects, or 3) People who have messed up caloric intakes to not really match their goal which skew the end result.
Anabolic response:
Insulin Response and Nutrient partitioning:
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"GLUT4: Glucose transporter type 4 is a protein responsible for insulin-regulated glucose transport into the muscle cell. It increased by a whopping 28% in F but only 2-3% in C (not mentioned in the paper but this is my estimate based on the graphs). This partly explains why F saw superior results in regards to glucose tolerance and insulin sensitivity.
Since GLUT4 is triggered by AMPK, which is increased when glucose availability is low, i.e. during fasted training, one would assume the GLUT4 increase could then be explained by an increase in AMPK. This was found to be true: AMPK increased by 25% in F, which correlated closely with the increase in GLUT4 content."
Metabolic enzymes: Very fittingly, the same group of enzymes that were investigated in the study I covered in "Fasted Training Boosts Endurance and Muscle Glycogen" were looked at here.
Interestingly, changes in citrate synthase and HAD, two markers for fuel-utilization efficiency, were not different between F and C. However, two other important markers for glucose and fat metabolism, FAT/CD36 and CPT1, were increased by ~30% in F. C saw no increase at all.
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Body composition: Now this is very interesting. Despite overfeeding the subjects with 1000 calories or more, F only gained 0.7 kg. From a scientific standpoint, this is deemed insignificant. That is, the gain could likely be attributed to chance or, very likely, fluctuations in body weight due to increased muscle glycogen. This lack of weight gain in F could not be explained by the training regimen. They were still overfed by 15-20% when accounting for the extra activity. This left the subjects with a theoretical surplus of 650 calories per day, on average, which should have resulted in weight gain equivalent to ~3.5 kg after six weeks.
What about C? They gained 1.4 kg, twice as much as F, despite doing the same amount of exercise and consuming the same amount of calories and macronutrients.
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More from Martin:
"The main findings of the present study were that: training in an overnight-fasted state enhances storage of muscle glycogen compared to training in the fed state; skeletal muscle of men and women respond differently in terms of oxidative activity to training in the fed and overnight-fasted state; and peak VO2 and peak power improved more when training in the fasted state compared to the fed state."
Questioning the dramatic increase (+54.7%) in muscle glycogen in the fasted group, the researchers were not able to find an answer based on unexpected confounders or behaviors between groups. Muscle biopsies were taken at the same time and there were no difference in diet in between groups.
"...it is highly likely that the differences in glycogen stores between groups reflect the training intervention and not exercise timing or pre-biopsy diet."
Moreover, these results are in line with a prior study that found similar results for fasted training.
"Importantly, our findings correspond to that of De Bock et al. confirming that training whilst circulating CHO levels are low increases the capacity to accrue glycogen in the trained muscles."
What might be the reason for the different effects between genders on oxidative enzymes? As mentioned previously, differences in fuel utilization. Males rely less on intramuscular triglycerides and fatty acids and more on glucose, while females burn a higher percentage of fat at any given exercise intensity. But why fed state training would then be more beneficial for females when it comes to "oxidative adaptation" requires further investigation.
More on fasted training and protein synthesis:
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In this study, subjects were split into two groups that were trained on two occasions separated by three weeks. The three-week rest period between sessions served as a "washout" period, in order to make sure that the prior session didn't interfere with the results obtained during the second test.
The workouts were fairly basic whole-body sessions: 3 x 8 in seven movements such as bench press, overhead press, curls and leg press.
One of the sessions (F) were performed on an empty stomach after an overnight fast.
The other session (B) was performed in the fed state. Subjects were given a breakfast of 722 kcal composed of 85% carbs, 11% protein and 4% fat, and training was initiated 90 minutes after the meal.
After the weight training session, both groups rested for 4 hours. At the one- and four-hour marks, muscle biopsies and blood tests were obtained . Participants were also also given a recovery drink to sip each hour during the rest period.
Results revealed that the F session had twice as high levels of p70s6k in comparison to the B when measured at the one-hour mark post-workout. Other myogenic transcription factors were also higher at this point, though not quite as pronounced as p70s6k. At the four-hour mark, the differences between the two groups had evened out.
Among other things, increased levels of p70s6k may lead to a faster transport of amino acids into the muscle cell membranes, which should lead to a more rapid and potent anabolic response to post-workout nutrient ingestion. The effects seen on the other myogenic signaling mechanisms could also affect muscle growth through other pathways.
Interesting. I used to train fasted a while ago but have since changed my tact (as I always do) and now train after a large feed. Seems to sit better with me this way.
Although if I do HIIT, then eating beforehand makes me wanna puke so its hard to find a good balance lol
That balance is key for me also.
When i trained weights fasted I would get light headed ( i always try to train max effort and intensity. As heavy as possible and as many reps as possible). Even with a shake before hand I would get blackouts especially squats.
When I do Cardio on the other hand I enjoy it much more fasted but will always have bcaa intra or before.
I guess my point is when I weight trained fasted my workouts suffered. I'd rather have a killer session with some food in me and do my cardio after lifting then, weight train at a less capacity.
This has turned into a "ill just throw a link down and agree with it " thread with hardly any personal experience discussion brought to the table so I'll be unsubbing now.
That balance is key for me also.
When i trained weights fasted I would get light headed ( i always try to train max effort and intensity. As heavy as possible and as many reps as possible). Even with a shake before hand I would get blackouts especially squats.
When I do Cardio on the other hand I enjoy it much more fasted but will always have bcaa intra or before.
I guess my point is when I weight trained fasted my workouts suffered. I'd rather have a killer session with some food in me and do my cardio after lifting then, weight train at a less capacity.
Most roundtables include experience but is mostly based off the research they study. Even if someone throws out their experience some people will still rebuttal with "oh you should do this or you should do that" when it suits that individual and their success because it suits them and its optimal for their schedule. Both are vital IMO, sometimes the things that dont seem like they would work on paper or in a lab show the best results for that individual hence why i believe there is no true "best way" to do things because everyone responds so differently. Some prefer the fasted training and some do not. Some experience greater focus/energy in a fasted state, and some are just horrible, groggy and tired. The only true way is to give it a good 4-8 weeks minimum of trying something new, try to adjust, and take notes on what works for your mood, energy, strength, and performance and then adjust. Same could be said with intra-workout carbs, meal timing, meal frequency etc. There will never be a one size fits all for every individual that walks, but i am always eager to see how other people do things and see what works for them because each piece of advice could be utilized to help give you an edge for something in the future or your current program/diet/training.
For me i can do both in a fasted/non fasted state
Fasted:
- Greater Energy (Pre-workouts do hit harder in a true fasted state)
- Have hit PR's in a fasted state and notice increased energy compared to a fed state, longer focus, and greater mental clarity
- Overall strength may not be up to par compared to training later or with food in me, but i still put in very good sessions
- Focus/Intensity remains high
- Less Vascularity/Pump
Fed:
- May feel a bit bloated depending on how close or what i eat pre-workout (usually a very light meal to fuel training and eat more post/pre bed)
- Strength may be greater (have hit more PR's in a fed state)
- Energy/Focus may be a bit less if using a pre-workout due to food in the system and effects not as great
- performance on par if not a bit better with food in me (tough to tell since i train fasted more often due to schedule/job)
- Vascularity/Pump greater with food/pre-workout meal in me compared to fasted
my expereinces
Ok, here is my anecdote;
I spent a week training fasted when on holiday. I trained first thing in the morning.
I was significantly weaker and felt nauseous every session. My workouts were significantly easier yet I found them harder than the much more rigorous workouts that I would usually put myself through.
In theory if I did them for long enough I should notice some form of adaptation to them. If I was forced to train first thing in the morning due to my work schedule then I would do it but I don't believe fasted training offers any advantage in terms of performance.
Agree with both of you. I can't train to my fullest potential fasted. My best workouts are always post a hefty carb weighted meal.Interesting. I used to train fasted a while ago but have since changed my tact (as I always do) and now train after a large feed. Seems to sit better with me this way.
Although if I do HIIT, then eating beforehand makes me wanna puke so its hard to find a good balance lol
This has turned into a "ill just throw a link down and agree with it " thread with hardly any personal experience discussion brought to the table so I'll be unsubbing now.
Irrelevant you unsubbed you're not supposed to be in hereThat balance is key for me also.
When i trained weights fasted I would get light headed ( i always try to train max effort and intensity. As heavy as possible and as many reps as possible). Even with a shake before hand I would get blackouts especially squats.
When I do Cardio on the other hand I enjoy it much more fasted but will always have bcaa intra or before.
I guess my point is when I weight trained fasted my workouts suffered. I'd rather have a killer session with some food in me and do my cardio after lifting then, weight train at a less capacity.
Most roundtables include experience but is mostly based off the research they study. Even if someone throws out their experience some people will still rebuttal with "oh you should do this or you should do that" when it suits that individual and their success because it suits them and its optimal for their schedule. Both are vital IMO, sometimes the things that dont seem like they would work on paper or in a lab show the best results for that individual hence why i believe there is no true "best way" to do things because everyone responds so differently. Some prefer the fasted training and some do not. Some experience greater focus/energy in a fasted state, and some are just horrible, groggy and tired. The only true way is to give it a good 4-8 weeks minimum of trying something new, try to adjust, and take notes on what works for your mood, energy, strength, and performance and then adjust. Same could be said with intra-workout carbs, meal timing, meal frequency etc. There will never be a one size fits all for every individual that walks, but i am always eager to see how other people do things and see what works for them because each piece of advice could be utilized to help give you an edge for something in the future or your current program/diet/training.
For me i can do both in a fasted/non fasted state
Fasted:
- Greater Energy (Pre-workouts do hit harder in a true fasted state)
- Have hit PR's in a fasted state and notice increased energy compared to a fed state, longer focus, and greater mental clarity
- Overall strength may not be up to par compared to training later or with food in me, but i still put in very good sessions
- Focus/Intensity remains high
- Less Vascularity/Pump
Fed:
- May feel a bit bloated depending on how close or what i eat pre-workout (usually a very light meal to fuel training and eat more post/pre bed)
- Strength may be greater (have hit more PR's in a fed state)
- Energy/Focus may be a bit less if using a pre-workout due to food in the system and effects not as great
- performance on par if not a bit better with food in me (tough to tell since i train fasted more often due to schedule/job)
- Vascularity/Pump greater with food/pre-workout meal in me compared to fasted
my expereinces
Now this was a helpful post.![]()
What about the post workout 'window'? Does anyone notice any difference between getting in some protein within 30 minutes or not? I know n=1 and it is uncontrolled, but I just want your personal opinions on what you feel works best
What about the post workout 'window'? Does anyone notice any difference between getting in some protein within 30 minutes or not? I know n=1 and it is uncontrolled, but I just want your personal opinions on what you feel works best
What about the post workout 'window'? Does anyone notice any difference between getting in some protein within 30 minutes or not? I know n=1 and it is uncontrolled, but I just want your personal opinions on what you feel works best
I can definitely say I feel better after eating after I lift. I get all shakey and dizzy almost hypoglycemic like if I dont eat a meal post workout. Rather or not that meal adds to "dem gainz" I havent really noticed a difference.
What about the post workout 'window'? Does anyone notice any difference between getting in some protein within 30 minutes or not? I know n=1 and it is uncontrolled, but I just want your personal opinions on what you feel works best
I still consume liquid nutrition post workout.
I don't think it is necessary per se but I find it difficult to eat immediately and I find my mental acuity diminishes if I consume nothing.
I can definitely say I feel better after eating after I lift. I get all shakey and dizzy almost hypoglycemic like if I dont eat a meal post workout. Rather or not that meal adds to "dem gainz" I havent really noticed a difference.
I love food, I love working out, I love GOOD supplements, and I am sure that I will love gear and PH's.
None of my gains or progress would have been possible without proper nutrition (most days of the week). And I have screwed myself out of more gains and a visible 6 pack because of my lack of discipline with my nutritional choices. But like I said, I love food and I am not a Competitor of any kind, so I am going to eat my cheeseburgers.
This belongs here right?![]()
In regards to gains, I don't really notice a difference with protein consumed immediately post workout. I am usually not hungry afterwards. The idea of a shower and nap is more appealing, but I will say once I finish my post workout meal I turn into a ravenous eating machine...impatiently awaiting the next meal.
What about the post workout 'window'? Does anyone notice any difference between getting in some protein within 30 minutes or not? I know n=1 and it is uncontrolled, but I just want your personal opinions on what you feel works best
I actually feel a lot better waiting between 45 minutes to an hour after.
Nice. Is this for whole food or a shake?
The studies were not geared toward a calorie deficit. And calling a calorie a calorie is simply misguided. Ketogenic diets improve CVD biomarkets and lipid profiles; this is shown in LCD and VLCKD.
Carbs are not the body's primary source of energy; they are only that way because you eat them and eating carbs inhibits lipolysis. Fat provides more energy per gram and is far more sustainable.
The body, once keto adapted, can use ketones to fuel exercise of any intensity and, the body is sufficiently capable of producing carbohydrates from non-carbohydrate sources.
You're forgetting a few key points here, man. Red blood cells require glucose as do specific areas of the brain. Not only that, but the nervous system also heavily relies on glucose as fuel. Those require about 500kcals of glucose to operate efficiently. Yes, ketones can be used as energy efficiently throughout the body but certain systems REQUIRE glucose, no two ways about it. Fatty acids are converted to Acetyl CoA and cannot make glucose, ketones yes but not glucose. Therefore, when on keto diets the only glucose source you're getting is from deamination of protein or from Glycerol, which can be converted to glucose or to pyruvate (then Acetyl CoA) but the rate that Glycerol (due to most fatty acids only containing one glycerol molecule) converts is minor. Making the sacrificing of protein (or high intake thereof) one of the only significant sources of glucose production and even then only certain amino acids can be converted to pyruvate (pyruvate -> glucose) others favor Acetyl CoA or go directly into the TCA cycle which can later be used for glucose.
All that being said, I'm not entirely sold that the body can "sufficiently" produce enough glucose to fuel the systems that only accept it as fuel.
BTW I used all those studies you put up showing keto diets as positive findings in defense of keto diets with my nutrition teacher. Thanks![]()
Amount of glucose needed changes when keto adapted
Amount of glucose needed changes when keto adapted
You're forgetting a few key points here, man. Red blood cells require glucose as do specific areas of the brain. Not only that, but the nervous system also heavily relies on glucose as fuel. Those require about 500kcals of glucose to operate efficiently. Yes, ketones can be used as energy efficiently throughout the body but certain systems REQUIRE glucose, no two ways about it. Fatty acids are converted to Acetyl CoA and cannot make glucose, ketones yes but not glucose. Therefore, when on keto diets the only glucose source you're getting is from deamination of protein or from Glycerol, which can be converted to glucose or to pyruvate (then Acetyl CoA) but the rate that Glycerol (due to most fatty acids only containing one glycerol molecule) converts is minor. Making the sacrificing of protein (or high intake thereof) one of the only significant sources of glucose production and even then only certain amino acids can be converted to pyruvate (pyruvate -> glucose) others favor Acetyl CoA or go directly into the TCA cycle which can later be used for glucose.
All that being said, I'm not entirely sold that the body can "sufficiently" produce enough glucose to fuel the systems that only accept it as fuel.
BTW I used all those studies you put up showing keto diets as positive findings in defense of keto diets with my nutrition teacher. Thanks![]()
Amount of glucose needed changes when keto adapted
"However, serum lipids generally improve with the low-carbohydrate diet, especially the triglyceride and HDL measurements. In sharp contrast, high-carbohydrate diets, which reduce high-density lipoprotein (HDL) cholesterol and raise triglyceride levels, exacerbate the metabolic manifestations of the insulin resistance syndrome [18]."
Any references for that?
However, the body limits glucose utilization to reduce the need for gluconeogenesis. In the liver in the well-fed state, acetyl CoA formed during the β-oxidation of fatty acids is oxidized to CO2 and H2O in the citric acid cycle. However, when the rate of mobilization of fatty acids from adipose tissue is accelerated, as, for example, during very low carbohydrate intake, the liver converts acetyl CoA into ketone bodies: Acetoacetate and 3-hydroxybutyrate. The liver cannot utilize ketone bodies because it lacks the mitochondrial enzyme succinyl CoA:3-ketoacid CoA transferase required for activation of acetoacetate to acetoacetyl CoA [3]. Therefore, ketone bodies flow from the liver to extra-hepatic tissues (e.g., brain) for use as a fuel;
Over the years I've done both setups... A quick PWO shake immediately after as well as nothing until a whole food meal 1hr or so later... I don't notice much difference either way but since I love to cram food and drink into my mouth as often as possible, I prefer the shake, then meal, then another, etc... I do find that during a cut, the post workout shake is an easy few hundred cals to remove and I don't seem to feel any difference as far as "extra" muscle loss.
I train faste and I'm routinely not hungry after my workout for about 2 hours
I take intra bcaa and post workout bcaas. Then more bcaas 2-3 hours later if I'm my hungry and eat my food when I'm hungry I've noticed good leaning and recovery this way
Plus I yak if I eat prior to the gym
The body can produce sufficient glucose from non-glucose sources (does a Lion eat Grass?) in order to supply the brain with adequete fuel. There is no need for Carbs.
Lactate is converted to pyruvate which can subsequently be used to produce glucose and likewise odd chain fatty acids produce succinyl COA which also produces glucose.
Acetic acid (from acetyl COA) combine with pyruvate to make glucose.
I like carbs. They make my belly and my muscles full![]()
Therefore, when on keto diets the only glucose source you're getting is from deamination of protein or from Glycerol, which can be converted to glucose or to pyruvate (then Acetyl CoA) but the rate that Glycerol (due to most fatty acids only containing one glycerol molecule) converts is minor. Making the sacrificing of protein (or high intake thereof) one of the only significant sources of glucose production and even then only certain amino acids can be converted to pyruvate (pyruvate -> glucose) others favor Acetyl CoA or go directly into the TCA cycle which can later be used for glucose.
Fun and relevant word: gluconeogenesis.
You don't need to eat carbs, hence this nifty metabolic process.
Yea... ^Sir skips a lot lol
Are you aware of the key roles protein plays in the body? Using protein to produce glucose via gluconeogenisis steals amino acids that may have been needed to synthesize an enzyme or antibody and so on...
In addition, the body also needs glucose to make some nonessential amino acids. So in the absence of carbs, you now have amino acids sacrificing themselves, to produce glucose, to make nonessential amino acids. Fatty acids cannot be used to synthesize proteins. Glycerol can contribute to the formation of nonessential amino acids (when nitrogen is available) BUT Glycerol isn't exactly sufficient (IMO) to sustain ALL these tasks that the absence of carbs is responsible for. That means you now have yet another important task of glucose in an environment that isn't producing adequate amounts, since you think its beneficial to not eat carbs.
"Does a lion eat grass" doesn't really apply to humans considering humans have evolved to use their brains differently than Lions and am quite sure have different nervous systems.
Lactate -> pyruvate conversion rate is 10:1. That provides a sufficient source of glucose? Pyruvate also converts downstream to Acetyl CoA or upstream to glucose. There is no guarantee that the synthesized pyruvate-> glucose will happen.
"Acetic acid (from acetyl COA) combine with pyruvate to make glucose. "
Which is all well and good but that conversion still requires pyruvate, which can after a number of processes be synthesized via glycerol. This occurs at an extremely limited rate due to the makeup of triglycerides or more specifically the small amount of glycerol yielded. 95% of the content within triglycerides (5% glycerol by weight) do not make glucose.
There is no need for carbs at all. That's a slightly irresponsible statement.
Yea... ^Sir skips a lot lol
Are you aware of the key roles protein plays in the body? Using protein to produce glucose via gluconeogenisis steals amino acids that may have been needed to synthesize an enzyme or antibody and so on...
In addition, the body also needs glucose to make some nonessential amino acids. So in the absence of carbs, you now have amino acids sacrificing themselves, to produce glucose, to make nonessential amino acids. Fatty acids cannot be used to synthesize proteins. Glycerol can contribute to the formation of nonessential amino acids (when nitrogen is available) BUT Glycerol isn't exactly sufficient (IMO) to sustain ALL these tasks that the absence of carbs is responsible for. That means you now have yet another important task of glucose in an environment that isn't producing adequate amounts, since you think its beneficial to not eat carbs.
Any references for that?
Within the brain, nervous system and red blood cells? Color me interested, I'd also be very interested in seeing some evidence that this occurs.
If you have access
PMID: 4915800
If not I can try and attach it
The body needs glucose, yes but this doesn't need to be supplied exogenously. Glycerol is not the only component that is used to provide energy to the body in absence of carbs.
It seems like you are making the assumption that ketosis = zero glucose when in fact this is not the case. ketosis =/= zero glucose manufacturing.
Also, can you state factually that the body cannot function properly in absence of exogenous carbohydrate? Because it seems like speculation at this stage
If you have access
PMID: 4915800
If not I can try and attach it
Read the studies; they show that the body can work and function without the need for carbs quite effectively via ketone use (yes, the brain can work on ketones).
Humans have adapted to low carb diets, hence the reason that we can produce glucose through other means. The body has sufficient capability to produce glucose through the mechanisms shown.
Pyruvate is constantly produced through normal metabolic functions; where it becomes an issue is when build-up exceeds removal (blood lactate levels are approx 1-2mmol/L at rest).
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And again, all unbound albumin fatty acids CAN be used as a fuel for the brain (as they can pass through the BBB). MCTs for example.
You can not base statements on assumptions: "There is no guarantee that the synthesized pyruvate-> glucose will happen"; What evidence is there that the body cannot function effectively in the absence of carbohydrate in the diet when Keto adpated (not just someone who has entered ketosis for 1-2 or 3 days).
Also remember that fats and triglycerides have sugar bonds and when they are cleaved (i.e. broken down) they release glucose into the bloodstream
Also, muscle proteins are spared via this process; Glycogen is spared which saves muscle proteins.
I never made that case. Not once did I say that, I also pointed out that glucose can be made with protein did I not? Also, did I state the "body" or did I say the brain, red blood cells and nervous system?
Cool ill check it out thanks Man
You jerks.... you just like to argue! :rant:
Debating lol. The best way to learn imo; lets you understand both sides to any argument![]()
Debating lol. The best way to learn imo; lets you understand both sides to any argument![]()
No doubt I read about the brain's ability to use ketones as fuel for like 4 hours last night, well into the morning lol