Yes, non-methylated prohormones like 1-AD and 4-AD don't require liver support.
Milk thistle tablets are very cheap, though, so you may as well take them.
I'm injecting test cyp for 10 weeks, bookended by methylated orals as a kickstart and a "kickstop". In the middle, I take 1-AD, to give my liver a rest, but give a strong boost to gains. Primobolan tabs can be used similarly.
1-AD stacked with a testosterone ester is even better than the old 1-AD / 4AD stack