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New Betaine Study

muscleupcrohn

muscleupcrohn

Legend
A study published earlier this year found that "high dietary choline and betaine intakes are significantly associated with favorable body composition in humans."
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We already know that betaine is a very useful supplement that has become a staple alongside supplements like creatine for many people on this forum. There are studies showing increases in body composition (increases in LBM AND decreases in body fat):
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reps performed and total bench press volume (and muscle oxygen consumption:
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and squats (within one week):
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vertical jump:
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and power:
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Back to the new study:
A total of 3214 subjects from the CODING (Complex Disease in Newfoundland population: Environment and Genetics) study were assessed. Dietary choline and betaine intakes were computed from the Willett Food Frequency questionnaire. Body composition was measured using dual-energy X-ray absorptiometry following a 12-hour fast. Major confounding factors including age, sex, total calorie intake and physical activity level were controlled in all analyses.
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The study also stated:
To the best of our knowledge, this is the first large cross-sectional study specifically designed to investigate the association between dietary choline, betaine intakes and DXA-derived body composition. We found significant associations of higher dietary choline and betaine intakes with better body composition profile (lower %BF, higher %LM).
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The beneficial effect of dietary choline and betaine intakes on obesity was demonstrated in every obesity measurement in both women and men...
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dietary betaine intake (mg/kg/day) was significantly lower by 13.3%, 33.0%, 29.7%, and 41.7% in female overweight, female obese, male overweight and male obese groups, respectively, compared to normal weight groups.
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As for what was considered low, medium, and high betaine intake:

Women:
Low: 37mg/day
Medium: 87mg/day
High: 201mg/day

Men:
Low: 39mg/day
Medium: 88mg/day
High: 217mg/day

As you can see, even the high betaine intake is much less than the 2.5g used in many studies on resistance trained individuals.

Yes, this was "only" an association study, but we already have multiple studies showing that betaine supplementation can benefit body composition. What this study provides that the others don't is a much larger sample size. While this is not a double-blind placebo-controlled study, it was "a large population based cross-sectional study" with over 3,000 subjects. Between this larger association study and the handful of more controlled studies with smaller sample sizes, we can get a better picture of the potential benefits of betaine (specifically improved body composition; increased LBM and reduced fat).

In my opinion, betaine has earned its spot among staple supplements for athletes and gym goers alongside other proven ingredients like creatine monohydrate. In addition to the body composition and performance benefits of betaine, there is also research suggesting betaine can be beneficial for the liver:
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and "is an important nutrient for the prevention of chronic disease"
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In conclusion, betaine appears to be both an effective ergogen (capable of improving body composition and performance), as well as a generally healthy ingredient with a variety of benefits for more than just athletes/lifters. Any time you have an affordable ingredient that is not only "effective" (helps us get bigger and/or stronger), but also generally healthy and even god for you, I feel it deserves a spot in your supplement arsenal (for me these are creatine monohydrate, betaine, and taurine, all of which, and then some, I get from PowerMax XT).

For people who aren't already taking betaine, there are several products that contain full doses of betaine, as well as several other "staple" ingredients such as creatine, including:

-Performax Labs PowerMax XT
-Olympus Labs Tr1umph
-PES Ergonine
-iForce Finish Line
 
muscleupcrohn said:
A study published earlier this year found that "high dietary choline and betaine intakes are significantly associated with favorable body composition in humans."
Invalid Link Removed

We already know that betaine is a very useful supplement that has become a staple alongside supplements like creatine for many people on this forum. There are studies showing increases in body composition (increases in LBM AND decreases in body fat):
Invalid Link Removed
reps performed and total bench press volume (and muscle oxygen consumption:
Invalid Link Removed
and squats (within one week):
Invalid Link Removed
vertical jump:
Invalid Link Removed
and power:
Invalid Link Removed

Back to the new study:


The study also stated:




As for what was considered low, medium, and high betaine intake:

Women:
Low: 37mg/day
Medium: 87mg/day
High: 201mg/day

Men:
Low: 39mg/day
Medium: 88mg/day
High: 217mg/day

As you can see, even the high betaine intake is much less than the 2.5g used in many studies on resistance trained individuals.

Yes, this was "only" an association study, but we already have multiple studies showing that betaine supplementation can benefit body composition. What this study provides that the others don't is a much larger sample size. While this is not a double-blind placebo-controlled study, it was "a large population based cross-sectional study" with over 3,000 subjects. Between this larger association study and the handful of more controlled studies with smaller sample sizes, we can get a better picture of the potential benefits of betaine (specifically improved body composition; increased LBM and reduced fat).

In my opinion, betaine has earned its spot among staple supplements for athletes and gym goers alongside other proven ingredients like creatine monohydrate. In addition to the body composition and performance benefits of betaine, there is also research suggesting betaine can be beneficial for the liver:
Invalid Link Removed
and "is an important nutrient for the prevention of chronic disease"
Invalid Link Removed

In conclusion, betaine appears to be both an effective ergogen (capable of improving body composition and performance), as well as a generally healthy ingredient with a variety of benefits for more than just athletes/lifters. Any time you have an affordable ingredient that is not only "effective" (helps us get bigger and/or stronger), but also generally healthy and even god for you, I feel it deserves a spot in your supplement arsenal (for me these are creatine monohydrate, betaine, and taurine, all of which, and then some, I get from PowerMax XT).

For people who aren't already taking betaine, there are several products that contain full doses of betaine, as well as several other "staple" ingredients such as creatine, including:

-Performax Labs PowerMax XT
-Olympus Labs Tr1umph
-PES Ergonine
-iForce Finish Line
Click to expand...

Good find. Definitely a staple of mine. And it's cheap!
 
I get major gastric distress when trying to take betaine (bulk powder), even in small doses (1mg). I think I even tried 500mg once, and it still sent me running to the bathroom. I can take the capsules, but they are quite a bit more pricey than the bulk powder..
 
Sparkss said:
I get major gastric distress when trying to take betaine (bulk powder), even in small doses (1mg). I think I even tried 500mg once, and it still sent me running to the bathroom. I can take the capsules, but they are quite a bit more pricey than the bulk powder..
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Have you tried taking it with food?
 
muscleupcrohn said:
Have you tried taking it with food?
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I thought about that, since when I take the capsules, it is usually with my daily vitamins, which is with breakfast. But when I take the powder in my protein shake it clobbers me. but I can also (usually) take a supp (PWO, etc) with betaine in it, even on an empty stomach, w/o problems. I tried two different betaine (powder) brands, no luck. What one do you use? From everything I read on it I agree it should be a staple right next to creatine, just wish it treated me better when I first take it.
 
I've used it a lot and love it. Great muscle fullness when I take it.
 
Great post!

I personally love oly Vital1ty. Betaine, creatine, and PS. I have 30 tubs in storage. Lol
 
Sparkss said:
I thought about that, since when I take the capsules, it is usually with my daily vitamins, which is with breakfast. But when I take the powder in my protein shake it clobbers me. but I can also (usually) take a supp (PWO, etc) with betaine in it, even on an empty stomach, w/o problems. I tried two different betaine (powder) brands, no luck. What one do you use? From everything I read on it I agree it should be a staple right next to creatine, just wish it treated me better when I first take it.
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I get my betaine from PowerMax XT. I've also gotten it from other supplements (daily staple supplements and various pre-workouts). As for bulk powders, I'm not sure if I'm allowed to list the companies here, but you can PM me.

For a while I mixed a ton of bulk powders every day (creatine, betaine, taurine, glutamine with alanine, etc), but it's so much easier to just get it all from one supplement (PowerMax, Triumph, etc). It saves a decent amount of time, and tastes a lot better too.
 
it is on sale right now for $4.99. Looks like they are pushing the Conqu3r supp now.
 
Excellent post and write-up here! Must've taken a while but these are the quality posts that make me love the forums
 
Sparkss said:
I get major gastric distress when trying to take betaine (bulk powder), even in small doses (1mg). I think I even tried 500mg once, and it still sent me running to the bathroom. I can take the capsules, but they are quite a bit more pricey than the bulk powder..
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Check your capsules, were you taking Betaine HCL or Betaine Anhydrous, thats a common complaint with Betaine HCL.
 
Adizzle1 said:
Check your capsules, were you taking Betaine HCL or Betaine Anhydrous, thats a common complaint with Betaine HCL.
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Betaine HCL isn't going to cause GI issues. More than likely is going to benefit the GI.
 
kbayne said:
Betaine HCL isn't going to cause GI issues. More than likely is going to benefit the GI.
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Really? I always thought the hcl was no bueno...
 
Why isn't it used instead then?
 
muscleupcrohn said:
I get my betaine from PowerMax XT. I've also gotten it from other supplements (daily staple supplements and various pre-workouts). As for bulk powders, I'm not sure if I'm allowed to list the companies here, but you can PM me.

For a while I mixed a ton of bulk powders every day (creatine, betaine, taurine, glutamine with alanine, etc), but it's so much easier to just get it all from one supplement (PowerMax, Triumph, etc). It saves a decent amount of time, and tastes a lot better too.
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Betaine has no taste, lol.
 
Jiigzz said:
Betaine has no taste, lol.
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I was saying that a flavored "staple" supplement tastes better than an unflavored mixture of several bulk powders including creatine, betaine, and other bulk powders. Creatine and betaine don't really have a taste, but a flavored powder still tastes better, haha.
 
Bulk cissus. Filthy. Absolutely FILTHY......
 
ryane87 said:
Bulk cissus. Filthy. Absolutely FILTHY......
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I believe it was bulk creatine CEE. When I first stated lifting, there were posts stating it was better than mono. I got some and the stuff is like straight battery acid. It burned all the way going down.
 
AntM1564 said:
I believe it was bulk creatine CEE. When I first stated lifting, there were posts stating it was better than mono. I got some and the stuff is like straight battery acid. It burned all the way going down.
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In this particular case, that was nature's way of telling you not to use it, haha.
 
AntM1564 said:
I believe it was bulk creatine CEE. When I first stated lifting, there were posts stating it was better than mono. I got some and the stuff is like straight battery acid. It burned all the way going down.
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Tastes like burning does not sound pleasant. Cissus tastes like eating dirt. Like your 4 or 5 year old self would love it.
 
AntM1564 said:
I believe it was bulk creatine CEE. When I first stated lifting, there were posts stating it was better than mono. I got some and the stuff is like straight battery acid. It burned all the way going down.
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Tastes like burning does not sound pleasant. Cissus tastes like eating dirt. Like your 4 or 5 year old self would love it.
 
Adizzle1 said:
Check your capsules, were you taking Betaine HCL or Betaine Anhydrous, thats a common complaint with Betaine HCL.
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I actually took both (at different times). I bought the HCL capsules before I knew the difference, then bought the anhydrous and switched to that. But (neither of) the capsules ever gave me any problem. It was only the raw betaine powder that did (when I added it to a protein shake).
 
kbayne said:
It aids in digestion for those who have poor stomach acid production.

Not an ergogenic.
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This, and I can speak from experience on this through past digestive issues it really seemed to help.

But no ergogenic benefit as Kyle said


To the taste discussion above, betaine is definitely pretty tasteless, and actually a little sweet.
 
An older study but interesting..
"Betaine supplement enhances skeletal muscle differentiation in murine myoblasts via IGF-1 signaling activation"
Background
Betaine (BET) is a component of many foods, including spinach and wheat. It is an essential osmolyte and a source of methyl groups. Recent studies have hypothesized that BET might play a role in athletic performance. However, BET effects on skeletal muscle differentiation and hypertrophy are still poorly understood.

Methods
We examined BET action on neo myotubes maturation and on differentiation process, using C2C12 murine myoblastic cells. We used RT2-PCR array, Western blot and immunofluorescence analysis to study the BET effects on morphological features of C2C12 and on signaling pathways involved in muscle differentiation and hypertrophy.

Results
We performed a dose–response study, establishing that 10 mM BET was the dose able to stimulate morphological changes and hypertrophic process in neo myotubes. RT2-PCR array methodology was used to identify the expression profile of genes encoding proteins involved in IGF-1 pathway. A dose of 10 mM BET was found to promote IGF-1 receptor (IGF-1 R) expression. Western blot and immunofluorescence analysis, performed in neo myotubes, pointed out that 10 mM BET improved IGF-1 signaling, synthesis of Myosin Heavy Chain (MyHC) and neo myotubes length.

In addition, we investigated BET role on myoblasts proliferation and differentiation. During proliferation, BET did not modify C2C12 proliferative rate, but promoted myogenic induction, enhancing MyoD protein content and cellular elongation. During differentiation, BET caused an increase of muscle-specific markers and IGF-1 R protein levels.

Conclusions
Our findings provide the first evidence that BET could promote muscle fibers differentiation and increase myotubes size by IGF-1 pathway activation, suggesting that BET might represent a possible new drug/integrator strategy, not only in sport performance but also in clinical conditions characterized by muscle function impairment.

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SNS 100G can be found for under $10 if you look hard enough :)
 
justhere4comm said:
Would this enhance the effects of MK677 or am I off base here?
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Assuming the study has merit of Betaine promoting muscle fibers differentiation stacking the two seems logical..another idea is stacking Betaine with MGF which promotes muscle cell proliferation...perhaps good synergy between compounds that proliferate and differentiate.
 
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