Take Aegis and Talos along with Mechabol, and with meals. You can take milk thistle and NAC at the same time, if you'd like. Dietary fats, in large enough quantities, can dramatically improve the gastrointestinal absorption of lipophilic supplement ingredients.... like mechabol, resveratrol, CoQ10, silybin (to some degree), and many others.
Liver supports won't decrease & should even increase absorption. (TUDCA and sodium taurocholate are actually 'oral penetration enhancers' of a sort -- they can solubilize lipophilic/poorly-bioavailable ingredients & increase the extent and rate of their absorption. And PPC is, pound for pound, better than dietary fats.) ...That said, there's some alarming data re: milk thistle decreasing androgen receptor function, but I don't think that it's 'clinically relevant', so I see no harm in taking milk thistle...