Speedbacker
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That sucks you didn't see the "unbelievable" muscle growth you're supposed to get when myostatin is "blocked". That's a ton of money to spend, but gotta give you credit for trying that.
so at this point is the celldyne supplement considered bunk?well its nothing new like i said before the biggest muscle growth i notice and its still quite visible today is my trap and shoulder muscle it stands out from the rest
Nobody knows. Nobody's used it. I don't think too many people are getting their hopes up because of it, but I think it's supposed to be released in a month or so and there will be people who will buy it, so I guess we'll find out shortly. I wouldn't expect much though.so at this point is the celldyne supplement considered bunk?
so at this point is the celldyne supplement considered bunk?
1: Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E985-91. Epub 2006 Dec 5.
Muscle growth after postdevelopmental myostatin gene knockout.Welle S, Bhatt K, Pinkert CA, Tawil R, Thornton CA.
Department of Medicine, University of Rochester, Rochester, NY, USA. [email protected]
Constitutive myostatin gene knockout in mice causes excessive muscle growth during development. To examine the effect of knocking out the myostatin gene after muscle has matured, we generated mice in which myostatin exon 3 was flanked by loxP sequences (Mstn[f/f]) and crossed them with mice bearing a tamoxifen-inducible, ubiquitously expressed Cre recombinase transgene. At 4 mo of age, Mstn[f/f]/Cre+ mice that had not received tamoxifen had a 50-90% reduction in myostatin expression due to basal Cre activity but were not hypermuscular relative to Mstn[w/w]/Cre+ mice (homozygous for wild-type myostatin gene). Three months after tamoxifen treatment (initiated at 4 mo of age), muscle mass had not changed from the pretreatment level in Mstn[w/w]/Cre+ control mice. Tamoxifen administration to 4-mo-old Mstn[f/f]/Cre+ mice reduced myostatin mRNA expression to less than 1% of normal, which increased muscle mass approximately 25% over the following 3 mo in both male and female mice (P<0.005 vs. control). Fiber hypertrophy appeared to be sufficient to explain the increase in muscle mass. The pattern of expression of genes encoding the various myosin heavy-chain isoforms was unaffected by postdevelopmental myostatin knockout. We conclude that, even after developmental muscle growth has ceased, knockout of the myostatin gene induces a significant increase in muscle mass.
PMID: 17148752 [PubMed - indexed for MEDLINE]
Thanks.human recombinant anti-gdf-8 and it want from TLR I WILL PM YOU WHERE I GOT IT FROM
The whois registrar info is probably someones home or his web person.You can't find the abstracts, the site looks sh*t, you have to pay to be on the waiting list?!?!?!?! Ot's registered as follows:
Domain name: folstaxan.com
Registrant Contact:
Celldyne Biopharma LLC
Richard Green ()
+1.2108869648
Fax: none
227 Adams Street
San Antonio, TX 78210
US
maps.google.com the zip, and then the street,
all the w's.san-antonio-texas.com is a B&B a few doors down,doesn't look to me like a place where a legit pharm company should be registered. In any case, it's residential. Either a massive con, or, if not, then definately it does't work and they want to cash in before everyone finds this out, by charging you to buy it?!
You can't find the abstracts
ABSORPTION PROFILE AND HORMONAL INFLUENCES OF Fertilized EGG YOLK INGESTION IN THE HUMAN
Journal of the American College of Nutrition, Volume 25, Number 5, October 2006
Colker, C. Peak Wellness, Inc. Greenwich, CT
Fertile egg yolks contain significant concentrations of follistatin. In an effort to identify whether this orally ingested source of naturally occurring follistatin is actually absorbed and pharmacokinetically active in the human model, this study was undertaken.
A male subject was chosen because the normal baseline male physiology does not regularly contain any measurable concentration of follistatin. Follistatin-rich fertile egg yolk powder properly processed to preserve active follistatin (FolstaxanTM) was obtained (Celldyne Biopharma, San Antonio, TX). After initial blood draw and subsequential oral Folstaxan dosing, serum follistatin levels were qualitatively and quantitatively) measured as an indicator of absorption. In addition, since we know follistatin is a negative modulator of myostatin, serum myostatin levels were qualitatively and quantitatively measured as an indication of hormonal influence and thus true pharmacokinetic activity. Testing utilized purchased follistatin and myostatin standardized for verification. Confirmations were run by ELISA and quantitations by Liquid Chromatography Tandem Mass Spectrometer with third degree fragmentation (Expertox, Deer Park, TX).
Results showed as predicted, a zero level of follistatin at baseline with a myostatin level of 46 pg/ml, 12 hours after FolstaxanTM dosing. Serum follistatin measured 57.1 pg/ml with a decline of myostatin to 34 pg/m1, 24 hours after the initial dosing, follistatin levels began to predictably drop from the time of initial dosing to 11.4 pg/ml. Yet myostatin continued to decline slightly with a 24-hour level of 31 pg/ml. These results clearly indicate that a fertile egg yolk powder properly processed to preserve active follistatin, when orally ingested, results in detectable serum follistatin. Furthermore, this resultant follistatin presence has significant pharmacokinetic activity is shown by the hormonal down regulation of serum follistatin.
Any update on when the actual product will be available, and perhaps more 'research' released on it? Last time I visited the site they were still selling 'delivery positions'.alright i was imformed by rick that theres a toll free number 1-866 -750-5168 up and running for anyone who dont want to order folstaxan on the computer
Cool. I think we'd have better luck praying for muscle than for this product to work to be honest, but I'm always open to hopefulness and the possibility that out of the BS something useful might arise.I just emailed rick asking him again whats the actual release date on this product and i will post what he says I must admit he have improved the website alot you can actually see some of the various effects of myostatin on human muscle but enough of that we want this product to be release and this is what i told rick, I will let you know what he says .peace!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Have you heard from him yet?I just emailed rick asking him again whats the actual release date on this product and i will post what he says I must admit he have improved the website alot you can actually see some of the various effects of myostatin on human muscle but enough of that we want this product to be release and this is what i told rick, I will let you know what he says .peace!!!!!!!!!!!!!!!!!!!!!!!!!!!!
lol, alright.not yet speed but i am hounding him though .
just waiting on my jugs of folstaxans to come in and then im gonna make a log on it good or bad hopefully its good
no i havent receieved it yet but was told today it would be at my front door next week.
The abstract looked good except for the fact that there was only one subject with no control which is just very strange and I don't see how it could ever be published in a respectable journal like that.the abstract looked viable. Without peer review there is no way to verify its aunthenticity. if someone can find this published somewhere that would be nice
It is important to note that fertilized egg yolk supplements are not new to the supplement market. I dunno the level of follistatin in them however
Was wondering about this too.The abstract looked good except for the fact that there was only one subject with no control which is just very strange and I don't see how it could ever be published in a respectable journal like that.
This folstaxan product, when he gets it.Can't log what?
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