Jebrook
Well-known member
Short answer is no.
MK-677
- Thread starter WhatsaRoid?
- Start date
The_Old_Guy
Well-known member
Gotcha. I think I'm going to try 100mcg EOD for 4 weeks and then take a break. I may experiment with 200mcg. I just hope this MK is doing something - I have no numbing and no water retention at 10mg.
Also, seeing some varying data on half life - what do you make of this:
Minutes (716 is about 12 hours) ???
DirtyWilly
Member
Would someone who follows strict intermittent fasting see any benefit from MK?
From what I understand MK works because it's a ghrelin mimetic (increases ghrelin), which in turn raises GH/IGF-1. Someone following IF would already have high ghrelin levels. So wouldn't IF do the same thing or does MK push the body past what is possible to achieve through diet?
From what I understand MK works because it's a ghrelin mimetic (increases ghrelin), which in turn raises GH/IGF-1. Someone following IF would already have high ghrelin levels. So wouldn't IF do the same thing or does MK push the body past what is possible to achieve through diet?
kboxer7
Well-known member
There is some varying data out there regarding the half-life. I've seen anywhere from 12-28.5 hours in studies, which is why most dose once per day.I thought I saw one study that showed 36 hours but I can't find it at the moment so stick with the 12-28.5hr assumption.
The_Old_Guy
Well-known member
I jumped up to 20mg last night, after not noticing any numbness or water retention at 10mg. I woke up once and felt different and thought I was "number" - I'll have to make sure it wasn't placebo but I may need 20mg... which sucks, because it just cut my stash in half and RC MK is exspensive'er 
Jebrook
Well-known member
FWIW I've never had tingling at 10,20, or 30. Not even once. Had all the other sides though, bloat, lethargy, appetite, better sleep.I jumped up to 20mg last night, after not noticing any numbness or water retention at 10mg. I woke up once and felt different and thought I was "number" - I'll have to make sure it wasn't placebo but I may need 20mg... which sucks, because it just cut my stash in half and RC MK is exspensive'er
The_Old_Guy
Well-known member
I have zero, nada, zilch "sides" at 10mg... and I always sleep like a rock, so that wouldn't be a good indicator. I'll stick to 20mg for a while and see if I notice anything... this sh&t better be doing something
Edit Just grabbed two more bottles (180 caps 10mg) at PHW (Focused Nutrition Brand).
ericool007
Active member
I have zero, nada, zilch "sides" at 10mg... and I always sleep like a rock, so that wouldn't be a good indicator. I'll stick to 20mg for a while and see if I notice anything... this sh&t better be doing something
Edit Just grabbed two more bottles (180 caps 10mg) at PHW (Focused Nutrition Brand).
the only sides i get is bloat 10 or 20mg but it makes for a huge watery pump, looks like im on something for sure but with clear skin instead of acne covered shoulders lol
AdelV
Well-known member
I have zero, nada, zilch "sides" at 10mg... and I always sleep like a rock, so that wouldn't be a good indicator. I'll stick to 20mg for a while and see if I notice anything... this sh&t better be doing something
Edit Just grabbed two more bottles (180 caps 10mg) at PHW (Focused Nutrition Brand).
Looks like a solid brand, and normally PHW has on-going sales.
GavinStevens
New member
On Day 4 of MK-677 at 25/day.
I've noticed nothing but extreme hunger. I'm also dismayed that the only clinical studies I've seen on it show no increases in strength, just in fat-free mass. Increasing strength without disturbing my rising testosterone levels (recently prescribed 50mg/Clomid a day for my low T) was my goal in going with the MK.
Oh well. I'll keep going for a while anyway.
I've noticed nothing but extreme hunger. I'm also dismayed that the only clinical studies I've seen on it show no increases in strength, just in fat-free mass. Increasing strength without disturbing my rising testosterone levels (recently prescribed 50mg/Clomid a day for my low T) was my goal in going with the MK.
Oh well. I'll keep going for a while anyway.
GavinStevens
New member
I'm somewhat leery of the studies however.
I'm primarily interested in strength - but more particularly for increased mass-specific force in sprint performance.
I note that Dr. Ho's study on HGH injections showed a significant (4-5%) improvement in sprint performance. I understand that injected HGH is generally going to spike levels much higher than what MK-677 does, but he apparently provided only a low dose of HGH.
So I wonder if there's more going on. Obviously hopeful.
I'm primarily interested in strength - but more particularly for increased mass-specific force in sprint performance.
I note that Dr. Ho's study on HGH injections showed a significant (4-5%) improvement in sprint performance. I understand that injected HGH is generally going to spike levels much higher than what MK-677 does, but he apparently provided only a low dose of HGH.
So I wonder if there's more going on. Obviously hopeful.
anab0lix
Member
Recovery is definitely much improved on mk677 and muscle retention as well.
I have been taking agmatine sulfate caps 500mg along with 10mg cap of mk677.
Not exactly sure if it's helping either but arginine seems to have some synergy with the mk677?
Lucianooo
Active member
IMHO bro mk 677 alone will work with or without anything else., i tried huperzine EGCG,Melatoni at night but no difference
anab0lix
Member
Oh I'm aware lol just agmatine it self is good to take so I just take it at night along with the mk677. I also take melatonin pretty often since I can't sleep well so it works out anyways.
edje007
Well-known member
I would not go so far in saying it causes lethargy.
Depends on a lot of different factors. Dosing...timing...etc
For me it doesn't cause lethargy. I have used it for over 6 months at 10mg (couple of weeks on 20mg)
Eddie1267
New member
When do you take it?
edje007
Well-known member
I take it before I go to sleep. Really a game changer for sleep quality!
Have tried it in the morning but the way it helps with getting a good nights rest made me go for the pre bed dosing.
Rocket3015
Legend
I take it in the am but have never had a problem with lethargy. I may try it at bed time to see if sleep improves..
Rocket3015
Legend
I'm sold will try tonight !
smith_69
Well-known member
whichy brand good sir
Burnfire
Well-known member
OL gharine right now, gonna buy some FN to throw that in.
GavinStevens
New member
I don't experience any lethargy from it. I do sleep better, though the difference is not dramatic. More impressive is what Burnfire said: I feel more refreshed with less sleep.
The hunger pains have at least temporarily gone away after one week on it.
The hunger pains have at least temporarily gone away after one week on it.
Jebrook
Well-known member
This is how it benefits me also. Almost too well. If I get my sleep disturbed I already feel rested and ready to get up even after only 5-6 hours. 6-7 was my normal sleep duration before, yet always felt sleep quality was poor and would get lethargic during the day. No lethargy for me with Gharine at all. Serious bloat at higher doses though. Maybe starting to see joint benefits finally although it's not for sure yet if this is incidental. Hoping it continues.
anab0lix
Member
From the incredible recovery increase, literally haven't had any severe DOMS since and minimal soreness that disappears in a very short while after hard workout days, faster gains, better recomp effect, better muscle retention.
Even though I can not sleep for jack **** when I do fall asleep I also seem to start dreaming right away. That has to be saying something. Fall into deep sleep quick!
Before I started mk677 and would get only 3-5 hrs of sleep I would feel like death all day. But now even when that happens I still feel half human and not as bad. This could also be associated with rhodiola and ashgawanda but most likely the better sleep I get in a short amount of time from the mk677.
Oh and one last thing. My upper middle back pain/tightness is nearly non-existant now. It's god damn amazing.
My worn out left shoulder socket seems to be improving somewhat but I sure as hell know if I wasn't on this stuff I wouldn't be able to do half the exercises I am doing now.
My left elbow tendinitis has also improved immensely. It's just really great.
Thanks highschool wrestling!:FUfinger:
The only downside I still seem to have is my left form arm weakness. It was always like this which I believe is related to the elbow tendinitis but nowadays it gets so painfully pumped I can't even make a fist during the middle of my workout and have to take a few minute breaks here and there rubbing and massaging it.
Don't actually know if this has to do with the gh carpal tunnel syndrome side effect but read that usually goes away after a few weeks. Hopefully that's the case.
Honestly don't know if my bones are actually slightly thickening or if it's from slight bloat but my watch feels tight as all hell now on my wrist. There's no mistake.
Even though I can not sleep for jack **** when I do fall asleep I also seem to start dreaming right away. That has to be saying something. Fall into deep sleep quick!
Before I started mk677 and would get only 3-5 hrs of sleep I would feel like death all day. But now even when that happens I still feel half human and not as bad. This could also be associated with rhodiola and ashgawanda but most likely the better sleep I get in a short amount of time from the mk677.
Oh and one last thing. My upper middle back pain/tightness is nearly non-existant now. It's god damn amazing.
My worn out left shoulder socket seems to be improving somewhat but I sure as hell know if I wasn't on this stuff I wouldn't be able to do half the exercises I am doing now.
My left elbow tendinitis has also improved immensely. It's just really great.
Thanks highschool wrestling!:FUfinger:
The only downside I still seem to have is my left form arm weakness. It was always like this which I believe is related to the elbow tendinitis but nowadays it gets so painfully pumped I can't even make a fist during the middle of my workout and have to take a few minute breaks here and there rubbing and massaging it.
Don't actually know if this has to do with the gh carpal tunnel syndrome side effect but read that usually goes away after a few weeks. Hopefully that's the case.
Honestly don't know if my bones are actually slightly thickening or if it's from slight bloat but my watch feels tight as all hell now on my wrist. There's no mistake.
cheeky1
Active member
Comparing apples & oranges there my friend. If you're expecting exogenous HGH type results then you're going to be disappointed. Mk will assist with the promotion of natural GH levels, not add to them. For recovery, repair, regeneration & even size it's a very useful compound, but it's not noted for an ability to increase strength.
cheeky1
Active member
anab0lix
Member
I added some other benefits I've been feeling in that post if you missed it since I added it on after I already posted it.
A simple 10mg cap prebed! And yes rhodiola and ksm66 really made a one hell of a difference with me being able to cope with stress.
Not all herbs and vitamins are a sham, really happy about that lol
cheeky1
Active member
Thanks mate. Yep, it's easy to get behind on some of these threads, they move fast these days!
Only 10mg, be interesting to see what your body does at 20mg, If you go there.
I'll take herbs & vits over meds any day! In the news here in Oz - there's been 6 organ failures attributable to natural supplements in the last 5 years, so once again the AMA wants pollies to step in & force additional regulation of some sort. Oh please, how about you show me how many deaths and serious illnesses have been attributed to OTC & prescription meds over the last 5 years? Or how many health successes have been achieved by using natural products? Big Pharma - get your dirty, filthy mitts out of my supplements!
anab0lix
Member
I think I'll stick to 10mg tbh. Don't have an unlimited amount of stock of this stuff and if it ain't broke don't fix it!
But yeah big pharma at it again like always. Not a big surprise ha.
Aren't Australias drug laws and customs already extremely uptight?
cheeky1
Active member
Fair enough. Why not try 20mg one of these days (maybe for 3 - 4 days) & see if you notice any difference?
Yes, though I would say our natty products & practitioners still have more freedom than in the US, but regulation is quite tight, especially with manufacturing & importation, and we don't get all the goodies other countries know & Love. Yohimbe, DHEA, Melatonin to name but a few. Oh and DMAA! I rely on some of the fine AM supporting vendors for much of my stock :wink1:
anab0lix
Member
Possibly will try. But from what most of have been saying is just extra bloat and not much other benefits. All I could possibly see helping is maybe a rise in appetite.
Also remember most studies show this stuff works better as time goes on so it just keeps on getting better and better the longer you take it.
You guys can't even get DHEA and Melatonin? Every country has it's whack laws I guess ha
cheeky1
Active member
Yeah but some do get far greater benefit at a higher dose. Agreed on the need for longer use for max benefit. I've just finished 3 mths at 10mg & will now try 3 months at 20mg, if I can take the lethargy again. If all is good i'll follow that with 3 months at 30mg (maybe) & see if the gradual increase nets me any further benefits.
Yeo, DHEA & melatonin are prescription only. Yohimbe & DMAA are illegal. Whack is one way to put it! :yuck:
anab0lix
Member
I still am on the younger side so I really don't see the need to go past 10mg. But people change and I may try it. I am only about a 1 month and a week in so it's still very early for me.
Lol prescription melatonin and dhea? HA! In a sense they are hormones no? Kind of makes sense I guess...
GavinStevens
New member
Oh, I'm not expecting exogenous HGH-type results. I'm simply interested in some results.
The question I'm essentially raising - because I don't know much about this stuff - is where is the difference?
Exogenous HGH will spike GH levels to supraphysiological levels.
MK-677 is a secretagogue that will elevate natural GH production to the top of, or perhaps above, the natural range.
How high do you have to get these levels to notice the performance-enhancing results?
I'd love to get to Dr. Ho's paper itself, as perhaps it has bloodwork results on it, but all I can find is articles about the study. It apparently showed a 4-5% reduction in 100 meter sprint times after "low" exogenous HGH injections.
How low? I don't know. I'll ask Dr. Ho.
mfg:
cheeky1
Active member
HardB0iled
Active member
Just put them in 7 day pill box with your daily, fish oil, etc. and put in your checked baggage. That's what I do. They're not gonna bother worrying about a few pills.
cheeky1
Active member
Spot on. Nothing in Mk will test up via swab & they certainly won't spin it up to check what it is. I always suggest to my customers to grab an empty bottle of something like Vitamin C or D & drop them in that (check countries laws on vitamins if in doubt), but the pill box is also a viable option.
If you're going to lose sleep over it then wait until you get back, no big deal.
smith_69
Well-known member
that's what I do- only BAD thing- everything comes out smelling like Vit B lol
cheeky1
Active member
Get Solgar sublingual B - it's delicious! :13:
Rocket3015
Legend
I have never had anyone question my 7 day pill box.