MK-677

I'm on 30mg for about 4 months I think. 20 mg for 2 months at one point. I might taper back to 20mg soon to ration the 6 bottles I have left. I love being at 30mg though.
 
Jebrook said:
4 weeks. The bloat already started to accumulate from 20. Took two weeks to taper back to 10. Now the bloating is essentially gone.
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have you tried manipulate diet carbs vs protein sodium etc when you was on 30 mg to minimize the water retention ?
 
bobi593 said:
have you tried manipulate diet carbs vs protein sodium etc when you was on 30 mg to minimize the water retention ?
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Carbs were low to moderate, sodium was nil, and protein around .8 grams per body weight but didn't help much. Usually I retain very little water.
 
Currently on month 6 of ghar1ne and numb hands are becoming crazy, even if i rest for 5 minutes. Sleep is very deep and dreams are crazy sometimes. In my experience more than 20-30 mg is a waste.i will keep you guys update here since im running it for an entire year
 
However to minimize the bloating effects i highly suggest you guys to use low-sodium salt and keep you potassium level high.
 
Anyone recommend morning dosage vs pre bed?

My mate says he wakes up tired, sore eyes all the time! He doses right before bed?
 
AdelV said:
Anyone recommend morning dosage vs pre bed?

My mate says he wakes up tired, sore eyes all the time! He doses right before bed?
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I always assumed pre-bed is best due to the bodies natural tendency to secrete more GH while asleep, and to mitigate any of the Ghrelin release. Also, any Melatonin use to inhibit Somatostatin, would best be done at bed time. I guess Hup-A is ok at any time. But I'm a newb cherry when it comes to GH.
 
The_Old_Guy said:
I always assumed pre-bed is best due to the bodies natural tendency to secrete more GH while asleep, and to mitigate any of the Ghrelin release. Also, any Melatonin use to inhibit Somatostatin, would best be done at bed time. I guess Hup-A is ok at any time. But I'm a newb cherry when it comes to GH.
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Well MK 677 has a 24 hour half life so dosage time shouldn't really matter that much. However some people see more side effects taking it in the morning vs at night, and vice versa. I personally take mine first thing in the morning, it doesn't really make a difference to me.
Definitely wouldn't take melatonin any other time than before bed. I have yet to experiment with Hup-A though.
 
BamBam0319 said:
Well MK 677 has a 24 hour half life so dosage time shouldn't really matter that much. However some people see more side effects taking it in the morning vs at night, and vice versa. I personally take mine first thing in the morning, it doesn't really make a difference to me.
Definitely wouldn't take melatonin any other time than before bed. I have yet to experiment with Hup-A though.
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Ok, cool, thx. I have absolutely zero side effects 1 week in, so I'm staying with what I got :)
 
The_Old_Guy said:
Ok, cool, thx. I have absolutely zero side effects 1 week in, so I'm staying with what I got :)
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Any benefits yet? I haven't had any bad side effects (bloating, lethargy) other than when I first started MK 677, but the quality sleep has stuck with me even at 10mg.
 
Lucianooo said:
Currently on month 6 of ghar1ne and numb hands are becoming crazy, even if i rest for 5 minutes. Sleep is very deep and dreams are crazy sometimes. In my experience more than 20-30 mg is a waste.i will keep you guys update here since im running it for an entire year
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Thanks for the advice I'll be running for a year as well, 10mg. I could do 20mg at a year, but I want to keep the mg lower.
 
BamBam0319 said:
Well MK 677 has a 24 hour half life so dosage time shouldn't really matter that much. However some people see more side effects taking it in the morning vs at night, and vice versa. I personally take mine first thing in the morning, it doesn't really make a difference to me.
Definitely wouldn't take melatonin any other time than before bed. I have yet to experiment with Hup-A though.
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I've been taking 10mg for 3 months now, 2-3 weeks ago I added some Hup-A in the morning.
 
Burnfire said:
Thanks for the advice I'll be running for a year as well, 10mg. I could do 20mg at a year, but I want to keep the mg lower.
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My suggestion is always to keep it low. Then before you decide to bump up the dose (presuming you feel the need), I would first try to "amplify/supercharge" the 10mg by using somatostatin inhibitors. I'd start with a mild one like melatonin at night, then Hup-A, then a combo of the two. Other somato inhibitors exist but those are my go to ones due to low sides + low cost.

After you've done that for a few months etc, then ramp to 20mg (if you feel the need), and repeat adding in the somatostatin inhibitors.

So as an example (duration on each dose before adjustment will be purely individual):

Months x-x 10mg
Months x-x 10mg + Melatonin
Months x-x 10mg + Hup-a / melatonin
Months x-x 20mg (no somato inhibitors)
Months x-x 20mg + Melatonin
Months x-x 20mg + Hup-a / melatonin

And so on....

By using this strategy you can DRAMATICALLY extend the lifespan of each bottle...which is precious since its out of production by supp companies (yes I know sketch RC still exists).
 
kboxer7 said:
My suggestion is always to keep it low. Then before you decide to bump up the dose (presuming you feel the need), I would first try to "amplify/supercharge" the 10mg by using somatostatin inhibitors. I'd start with a mild one like melatonin at night, then Hup-A, then a combo of the two. Other somato inhibitors exist but those are my go to ones due to low sides + low cost.

After you've done that for a few months etc, then ramp to 20mg (if you feel the need), and repeat adding in the somatostatin inhibitors.

So as an example (duration on each dose before adjustment will be purely individual):

Months x-x 10mg
Months x-x 10mg + Melatonin
Months x-x 10mg + Hup-a / melatonin
Months x-x 20mg (no somato inhibitors)
Months x-x 20mg + Melatonin
Months x-x 20mg + Hup-a / melatonin

And so on....

By using this strategy you can DRAMATICALLY extend the lifespan of each bottle...which is precious since its out of production by supp companies (yes I know sketch RC still exists).
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Thank you for the good advice man! I've already thrown the hup a in.

Man I have to go with a company I trust..


BamBam0319 said:
Any differences since adding the hup-a in?
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I don't seem as groggy around mid day.
 
At 10mg, I really didn't notice anything... no help in the sleep department or help with recovery. As soon as I bumped it up to 20, sleep improved and I felt completely recovered with only 6 hours of sleep. Loving it.
 
halljo said:
At 10mg, I really didn't notice anything... no help in the sleep department or help with recovery. As soon as I bumped it up to 20, sleep improved and I felt completely recovered with only 6 hours of sleep. Loving it.
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I figured with 6 bottles of gharine I have already and getting a few bottles of Focused Nutrition Elite MK-677. I'll see what 6 months at 10mg does and if I feel the need bump to 20mg for 6 months.
 
Burnfire said:
I figured with 6 bottles of gharine I have already and getting a few bottles of Focused Nutrition Elite MK-677. I'll see what 6 months at 10mg does and if I feel the need bump to 20mg for 6 months.
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I'm jealous haha. Nearing the end of my first Ghar1ne bottle with only one left in the stash. Wishing I could afford more.
 
kboxer7 said:
My suggestion is always to keep it low. Then before you decide to bump up the dose (presuming you feel the need), I would first try to "amplify/supercharge" the 10mg by using somatostatin inhibitors. I'd start with a mild one like melatonin at night, then Hup-A, then a combo of the two. Other somato inhibitors exist but those are my go to ones due to low sides + low cost.

After you've done that for a few months etc, then ramp to 20mg (if you feel the need), and repeat adding in the somatostatin inhibitors.

So as an example (duration on each dose before adjustment will be purely individual):

Months x-x 10mg
Months x-x 10mg + Melatonin
Months x-x 10mg + Hup-a / melatonin
Months x-x 20mg (no somato inhibitors)
Months x-x 20mg + Melatonin
Months x-x 20mg + Hup-a / melatonin

And so on....

By using this strategy you can DRAMATICALLY extend the lifespan of each bottle...which is precious since its out of production by supp companies (yes I know sketch RC still exists).
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Any particular brand of Hup-A people are liking ??
 
Lucianooo said:
Currently on month 6 of ghar1ne and numb hands are becoming crazy, even if i rest for 5 minutes. Sleep is very deep and dreams are crazy sometimes. In my experience more than 20-30 mg is a waste.i will keep you guys update here since im running it for an entire year
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Have you tried adding B12 for the tingling? I like Solgar sublingual Methycobalamin & I have been tested with elevated B12 levels whilst using it. 2000 - 5000mcg daily is a good target range. 1000mcg is sufficient for some people, if it works you'll know fairly quickly, try buying 1000mcg tabs & increasing by 1000mcg/day every few days until the tingling stops. No need to exceed 5000mcg, if that doesn't work (finish the bottle) then taking more is unlikely to result in any further benefit.
 
Just to add, this stuff really does work.

If I just miss a dose due to me being out for the night and I take it the next day. The hunger and hand swelling/numbing/tingling is back soon after the dosing. Not as strong as when I first started it but it's very noticeable.

Ever since I started taking it, it really seems to have been helping me pack on quality muscle much faster than when I wasn't on it. It just shows in the mirror.
 
anab0lix said:
Just to add, this stuff really does work.

If I just miss a dose due to me being out for the night and I take it the next day. The hunger and hand swelling/numbing/tingling is back soon after the dosing. Not as strong as when I first started it but it's very noticeable.

Ever since I started taking it, it really seems to have been helping me pack on quality muscle much faster than when I wasn't on it. It just shows in the mirror.
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That is the kind of results I like !
 
kboxer7 said:
My suggestion is always to keep it low. Then before you decide to bump up the dose (presuming you feel the need), I would first try to "amplify/supercharge" the 10mg by using somatostatin inhibitors.
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I started right out of the gate with 100mcg of Hup-A. I've always done 2.5mg Melatonin - I'm a little older and recall research that continued low dose Melatonin wasn't really a problem, especially for older dudes. Is there a tolerance/safety issue with Hup-A and/or Melatonin that you've researched?
 
The_Old_Guy said:
I started right out of the gate with 100mcg of Hup-A. I've always done 2.5mg Melatonin - I'm a little older and recall research that continued low dose Melatonin wasn't really a problem, especially for older dudes. Is there a tolerance/safety issue with Hup-A and/or Melatonin that you've researched?
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I can't recall any specific studies but I believe the common recommendation with Hup A was to cycle off every 2-3 weeks as the body builds a tolerance. I can't remember exactly who suggested that though.
 
Jebrook said:
I can't recall any specific studies but I believe the common recommendation with Hup A was to cycle off every 2-3 weeks as the body builds a tolerance. I can't remember exactly who suggested that though.
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Yup, guess I should have "Let Me Examine That For You" myself :)

Cycling of Huperzine-A tends to be used since the half-life exceeds 24 hours, and although a 'cycle' of Huperzine-A tends to last 2-4 weeks followed by a break the optimal cycle length is not yet known.
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Taking Melatonin is not associated with negative feedback (when taking supplementation causes your body to produce less of a hormone). It is also not addictive, and is not toxic.
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I am just over 4 weeks in on mk 10mg every night. And the hand tingling is getting to be more and more pronounced in the mornings I really feel it while I am driving into work
 
The_Old_Guy said:
I started right out of the gate with 100mcg of Hup-A. I've always done 2.5mg Melatonin - I'm a little older and recall research that continued low dose Melatonin wasn't really a problem, especially for older dudes. Is there a tolerance/safety issue with Hup-A and/or Melatonin that you've researched?
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Melatonin is safe long term, and the more research that is done, the more its being touted as a "miracle drug."

Hup-a on the other hand is an acetylcholinesterase Inhibitor (a very strong one at that), and we need AcH to regulate acetylcholine levels in our brain, which aid in regulating and safeguarding a number of neurochemical functions. So while it is not "toxic" at prescribed doses, it can be detrimental and/or disruptive to neuro pathways

I'll PM you a link where some decent research has been compiled and abbreviated if you want to give it a quick look.
 
kboxer7 said:
Melatonin is safe long term, and the more research that is done, the more its being touted as a "miracle drug."

Hup-a on the other hand is an acetylcholinesterase Inhibitor (a very strong one at that), and we need AcH to regulate acetylcholine levels in our brain, which aid in regulating and safeguarding a number of neurochemical functions. So while it is not "toxic" at prescribed doses, it can be detrimental and/or disruptive to neuro pathways

I'll PM you a link where some decent research has been compiled and abbreviated if you want to give it a quick look.
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Can share info on melatonin? I'm kind of curious about it.
 
UncleSarm said:
Can share info on melatonin? I'm kind of curious about it.
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That would be one lengthy write up lol...

In a short summation until I find the time to write five pages:

1. Neuro-protective
2. Reduction in body fat + increase in fatty oxidation
3. cardio-protective
4. Aids in establishing a healthy circadian rhythm
5. Increase in exercise tolerance
6. 10x+ increase in muscle gylcogen levels
7. Bone and teeth preserving agent
8. Anti-inflammatory agent
9. Somatostatin inhibitor (mild) - may aid in increased GH levels
10. MAY reduce estrogen in some men (does not seem to have a systemic effect though, despite being a stronger AI than Letro when studied in-vitro).

The list goes on really, but that's a start. If you want a reference for any specific benefit just hit me up and I'll be happy to dig it up.
 
5-Methoxy-N-Acetyltryptamine, MEL, Melatonina, Mélatonine, MLT, N-acetyl-5-methoxytryptamine, N-Acétyl-5-Méthoxytryptamine, Pineal Hormone.

possible uses - there are a few, some i didnt even realize and never tried-
can act as a sun screen- interesting, prevent sunburn and fall asleep at the same time- no that wont happen, as melatonin is produce during night hours, when its dark to help regulate sleep in our bodies.

it can also be used for headaches as well- there is a large list of reasons- blood pressure, before surgery, ringing in the ears.

it can increase symptoms of depression - obviously this depends on how severe the case is. The longer the use of mel, can then have a neg effect on you during the day, causing you to get tired- been there and done that. I worked a lot of late nights for years and my sleep patterns went to shyt.

another interesting note with mel is the ability to help with withdrawal symptoms- smoking for one. friend of mine was suggested to try this and it worked for him. i thought it was insane, but it worked- after he quit, he took it a few hours later and kept with it. hasnt smoked since.
 
kboxer7 said:
That would be one lengthy write up lol...

In a short summation until I find the time to write five pages:

1. Neuro-protective
2. Reduction in body fat + increase in fatty oxidation
3. cardio-protective
4. Aids in establishing a healthy circadian rhythm
5. Increase in exercise tolerance
6. 10x+ increase in muscle gylcogen levels
7. Bone and teeth preserving agent
8. Anti-inflammatory agent
9. Somatostatin inhibitor (mild) - may aid in increased GH levels
10. MAY reduce estrogen in some men (does not seem to have a systemic effect though, despite being a stronger AI than Letro when studied in-vitro).

The list goes on really, but that's a start. If you want a reference for any specific benefit just hit me up and I'll be happy to dig it up.
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add his list to mine, as K B said, there are many uses for this-

nice post bro
 
kboxer7 said:
Melatonin is safe long term, and the more research that is done, the more its being touted as a "miracle drug."

Hup-a on the other hand is an acetylcholinesterase Inhibitor (a very strong one at that), and we need AcH to regulate acetylcholine levels in our brain, which aid in regulating and safeguarding a number of neurochemical functions. So while it is not "toxic" at prescribed doses, it can be detrimental and/or disruptive to neuro pathways

I'll PM you a link where some decent research has been compiled and abbreviated if you want to give it a quick look.
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So how do *you* take it? (100mcg). After reading your link, I may adopt the 4 Day Max rule per week (every other night)? Still not sure about "cycle" length or break length?
 
The_Old_Guy said:
So how do *you* take it? (100mcg). After reading your link, I may adopt the 4 Day Max rule per week (every other night)? Still not sure about "cycle" length or break length?
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4-6 weeks. Then a month or so break.

I dose 5 on, 2 off. Morning or afternoon to avoid potential sleep disturbance.
 
kboxer7 said:
4-6 weeks. Then a month or so break.

I dose 5 on, 2 off. Morning or afternoon to avoid potential sleep disturbance.
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What do you think about Every Other Night for 4-6 weeks, and also what about dropping to 50mcg? All I want is the Somatostain inhibition, I could care less about any cognitive stuff - don't need it. Thanks!
 
The_Old_Guy said:
What do you think about Every Other Night for 4-6 weeks, and also what about dropping to 50mcg? All I want is the Somatostain inhibition, I could care less about any cognitive stuff - don't need it. Thanks!
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I don't see anything wrong with that. The half life is 36ish hours anyway.
 
kboxer7 said:
4-6 weeks. Then a month or so break.

I dose 5 on, 2 off. Morning or afternoon to avoid potential sleep disturbance.
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Can you send me that link also. I am running 10mg everyday And would like to increase the benefits with out upping the dose
 
fro60ol said:
Can you send me that link also. I am running 10mg everyday And would like to increase the benefits with out upping the dose
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Sure man. Coming your way.
 
fro60ol The_Old_Guy smith_69

Another possible way to "supercharge" your MK-677 on the cheap...TLDR is that a 40%+ extract of Tribulus sappoins seems to have an MOA that increases FREE igf-1. It does NOT increase Igf-1, but rather makes existing Igf-1 (which MK will increase) actually available for use.

Similar to "free test" vs "total test."

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I bought a large tub of SNS Trib which has a minimum sappoin content of 45%. Super cheap too.
 
The_Old_Guy said:
Ok, cool. What about going down to 50mcg?
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Somato inhibition is caused in a dose dependent manner with 200-400 mcg being where the magic is in terms of full potency. Most of this data comes from research on Alzheimer patients.

With that said, I'll reiterate that Hup-A is just as strong as pharma meds (and even has a longer duration of efficacy) for Ach inhibition. So its not like 50mcg isn't going to work, just not at full potential.

Hup-A can cause some sides for people so really its up to you to determine what dose you feel comfortable at from a safety and benefits perspective. It never hurts to start low at 50 mcg and if needed slowly work your way up to a higher dose.
 
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