Mirtazapine - anabolic/androgenic...?

Thank you for your response. I am aware of the increased appettite effects from Mirtazapine, but I was more curious to its effects on digestion. I have had IBS-C for a long time and have found SSRI's to be somewhat effective, although some side effects make them not worth it for me. I know Mirtazapine has an effect on norepinephrine, and while I felt great on effexor, I believe norepinephrine effects only make my IBS-C worse. I am wondering if Mirtazapine will have the same effect on my IBS-C as effexor did, or maybe since it is a strong anti-cortisol, it may help my IBS-C. Just wanted some antidotal feedback on Mirtazapine and its effects on digestion.
 
Mex
If you look up The Last Psychiatrist on the web, he has some great articles on Mirtz. Seriously clever dude. What I can tell you is this: Histamine causes IBS when it's above normal levels for the individual. It will increase stomach acid, cause discomfort and diarrhoea. Several of the old school antacids were actually h2 antihistamines. Estrogen is a major promoter of histamine, but there can be quite a few reasons for it's excess, eg lack of enzymes to clear histamine. Folks coming off antihistamines often develop IBS like symptoms and that's because the histamine rebound is setting off all kinds of signalling in the gut.
Mirtz is like a super-antihistamine - h1. It's effects are dose dependent. If you take a quarter pill that is enough to cover the histamine bases and no more. If you do half a tab then you are moving into the serotonin blockade territory. Take a full pill and you can expect the overflow to work on noradrenaline receptors. For me, a quarter pill is the hot spot. It chokes histamine and also lowers cortisol. If you have been running on high histamine for some time, the initial effect is like being hit with a sledge hammer. That shows just how high your histamine was in the first place, and how your body adapted to this level. In effect it is a 'comedown' and sometimes not a nice one.
I have not found a quarter pill to be an appetite booster, but anything over a half is. So, I can take a quarter at bedtime and maybe one at midday to ensure 24 histamine blockade. Histamine can hamper endocrine function. It plays havoc with hormone and neuro receptors leading to depression and anxiety. SSRI's probably promote histamine rather than lower it. Serotonin is, after all, a stress related hormone. If it wasn't, then stress adaptation drug tianeptine would not lower it. The irony is that tianeptine is as effective, if not better, than the ssri class yet it has the opposite effect. Go figure... In a really stressful situation in the past, I crunched half a mirtz under my tongue and within ten minutes I felt relaxed and calm. That is nothing to do with serotonin or noradrenaline which take weeks to rise - it is blockade of histamine. I've probably always been a high histamine type - never able to really relax unless sleeping. Always looking for new stimuli. Big appetite for risk.
Cannabis is an antihistamine and anti estrogen as well as a stress adaptive drug. It also promotes T long term. A very, very interesting drug. Looking forward to the OTC pill version in due course ;-)
 
Thank you for taking time for the very detailed response. I have been reading up on The Last Psychiatrist website, and you are right, there is a wealth of information on there. Interesting that you mention histamine as a culprit as I have always suspected my histamine was high due to congestion, allergies, etc., but never really looked into it. Now that you pointed out the connection between histamine and digestion I will have to read up more on it. I will take your advise on the Mirtazapine dosing and ask for it at my next doctors visit as it seems it could be very beneficial in my case.
 
mex, I apologize for not carefully reading your question. I hate it when people do that.

Andalucia, I take a quarter pill too! People have a hard time believing it does anything. I've recently tried just going off of it, and I can't. I've gone to 1/8 of a pill for two weeks, then a tiny crumb, then the anxiety and depression become worse. Back on a quarter of a pill and I'm back to baseline. I take a bunch of other meds too for depression and anxiety, so it's not the only one. It's just weird though.

Sorry to interrupt. Please pay more attention to mex if there are more questions.
 
No need to apologize, any added conversation is welcome and I appreciate your input. I do have a question for you though, what other types of meds do you take with the Mirtazapine? Do you use it in adjunct with a SSRI? Zoloft worked great with my IBS-C, except for the constant night sweats and insomnia. I was thinking in addition to Zoloft, Mirtazapine would be a nice addition for fix the sleep problem.
 
No need to apologize, any added conversation is welcome and I appreciate your input. I do have a question for you though, what other types of meds do you take with the Mirtazapine? Do you use it in adjunct with a SSRI? Zoloft worked great with my IBS-C, except for the constant night sweats and insomnia. I was thinking in addition to Zoloft, Mirtazapine would be a nice addition for fix the sleep problem.

Thanks for understanding. Celexa is my main anti-depressant. I also take Lamictal because I'm Bipolar. They don't work well because I'm med resistant, but it's a lot better than nothing. I've tried about everything there is, including Lithium and atypical antipsychotics. Mirtazipine or a tricyclic is great for insomnia because you don't build up a tolerance. But I have problems with that anyway. So yes, to answer your question. I used to take Prozac and a tricyclic (sp?) before I'm moved on to Zoloft, then Paxil, then Effexor which eventually backfired on me, then we found Lexapro/Celexa works well and doesn't mess with bipolar stuff for me.
 
Hi Andalucia. Your experiences with mirtazapine sure is interesting to read about, sounds almost to good to be true. Seems like you have been reading alot!
If you have the time, could you take a look at my thread regarding low T. I think maybe we have some things in common.
 
Hi guysNew to this forum but always pop in for a read. The Dr threads are great.i believe the trycyclic anti depressant Mirtazapine to be a growth agent. For the last year I suffered anxiety/mild depression and insomnia and gastro issues after a prolonged phase of working 14 hr days in construction. My docs refused to accept any other explanation other than depression, bar one who was a good listener and open to ideas. I agreed to try all the ssri's they prescribed and the sleeping pills too - none worked and most made me feel wired. My own research suggested adrenal issues and being much inclined to natural products, I put myself through a series of trials on various substances over 12 months - I had nothing to lose. It took that time to get a cortisol test from my local surgery (UK). The test is available ok, for free, but all but one of the docs I saw, claimed it was pointless - even one who specialises in cortisone injections! Sure enough, my cortisol was off the chart high.i had pre-empted this obvious revelation by hitting dhea at 100mg per breakfast and 50mg mid afternoon. My skin, energy, focus and physique all improved substantially as the dhea drove down my cortisol through an increase in sex hormone activity. Ironically, my high cortisol had not made me heavier but lighter and with much less fat - as it was always accompanied by adrenalin - symptom pounding heart day and night. Perhaps also, cortisol's suppression of T led to a dominance of E which in itself does not actually increase fat cell numbers but potentiates anxiety and insomnia. My testes were much larger and harder each morning and held their size over the day.i had been given MIRTAZAPINE by my doc at one point and used it on the odd day when sleep was vital - it is better than anything I have ever tried for that! I knew also, it was a sledgehammer for knocking down cortisol. Recently, I took it in conjunction with the DHEA. The effect was incredible. After 4 days use I went alpha male overnight. I have used plenty of aas cycles in the past, short and long, and I can tell you that the effect of dhea and 15mg Mirtazapine combined was psychologically far more powerful. Not just that, but my vascularity/pumped appearance was very notable. I felt stronger and über confident. I didn't walk faster, I walked slower...with real purpose. I noted that the rate of testicular shrinkage over the daily circadian rhythm was more pronounced (suggesting higher endogenous androgen levels), and I could control this by reducing the dose of dhea. It felt like a high dopamine mindset with the addition of strength and calm. The hangover associated with this drug disappeared after only two days and seemed to be caused by using dhea with it, for without - the day lag was heavy. Also, the dhea seemed to remove the excessive appetite associated with Mirtazapine and I wanted to eat meat constantly with the combo?!So... What is going on here? I actually want to do this again next week as it was such a good package - sleep, confidence, growth, mood, improvement in many functions. Is mirtazapine somehow potentiating the effects of dhea, or does it need dhea to maximise it's function? I would compare it, for me, to doing 40/50mg per day of dbol without the caffeine like symptoms, instead a calm and focused demeanour. My lifting felt really easy too. I appreciate everyone is different but I hope the merits of this personal experience are worth sharing.Nick

I know this post is VERY old but I want to rehash it. I am female and every time the docs put me on Mirtazapine I suffer hair loss (rare side effect) Can you smart people please explain to me why this would be happening? Is it affecting testosterone?
 
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