Methyl Cobalamin

I finally got some pins for my little pet, and I shot him with 500mg sub q in the booty. He is in prime placebo phase, but I could swear he seemed to more focused and energetic when performing some annoying manual labor. He's been trouble by inexplicable fatigue for as long as I can remember. The vet didn't have a clue as to why he feels like this. I'll keep an eye on the lil' guy, and update his progress.
 
Report: after my 5th consecutive day of 1000mcg dosing, no further benefits were encountered. Will slow down to E3D or so from now on, with the occasional venture into ED for a few days to see if it helps any more.
 
I'm gonna start ramping mine up. I pinned again this morning w/600mg. I have been taking EC in the a.m. to get me going during PCT. I'm only having 1 cup of coffee this morning. I'll test it out to see if that is enough to get me through 4.5 consecutive hours of teaching.
 
bull-terrier said:
No joy here with any test subject and sub-Q. Back to IM and ED. Maybe E3D or EOD soon, don't know...
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Are you saying you aren't noticing any effects (on your animals)? Or are you just saying that the benefits have reached their peak and have stabilized?

IM is probably a good idea if dosing less often.
 
BTW, IBE's Methyl B12 is red, so I can't really tell if there is any blood when aspirating. Any thoughts on the risk of hitting a vein w/B12?
 
i just shot the MB12 today, 500mcg. so far the effect is similar to B12 - altertness, good mood, energy. i feel a little more stimmed than with B12 (guess that's the efficacy of the drug)

IM in the pec, if anyone cares. it kicked in very quickly.
 
Beowulf said:
BTW, IBE's Methyl B12 is red, so I can't really tell if there is any blood when aspirating. Any thoughts on the risk of hitting a vein w/B12?
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I've read a study where individuals were given b12 intraveneously (sp) at a dosage of 10,000 mcgs per week to help treal mylenoma, so I dont think it would hurt anything if you did happen to inject into a vein.
 
Beowulf said:
BTW, IBE's Methyl B12 is red, so I can't really tell if there is any blood when aspirating. Any thoughts on the risk of hitting a vein w/B12?
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Hopefully your blood doesn't look that pinkish... I think you'd see blood if it went in there...
 
You really don't even need to aspirate with this small of a dose. It can be used intravenously as stated above. We harp on aspirating mostly for oil based compounds because if oil gets into a vein it could be very serious for your hamsters. Aqueous solutions like b12 pose no threat in this regard.
 
...unless there is a tiny amount of air inside the needle, and then you are giving yourself a clot, which will block a blood vessel at random. Maybe a tiny vessel in the skin. Maybe an artery that feeds your pituitary...

I know, THERE SHOULD NOT BE ANY AIR inside the needle. I say: paranoia = safety... In this instance.
 
True. A phlebotomist once told me that it takes an inordinate amount of air in an IV to do cause an actual embolism, however one should tap all bubbles out and aspirate anyways as a precaution. Tiny blood clots are not good.
 
So once you inject for 4-5days or so at a high dosage you only need to use every few days then? Are the effects there to the full potential on days you do not inject or how much do they diminish? I have been thinking about trying this for a while.
 
snakebyte05 said:
So once you inject for 4-5days or so at a high dosage you only need to use every few days then? Are the effects there to the full potential on days you do not inject or how much do they diminish? I have been thinking about trying this for a while.
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I hadn't taken the MB12 for quite a few days and pinned both yesterday and today. Yesterday I was mightily energized by it. It was easy for me to feel the added energy. I pinned 1000mcg again today and while energy was very good today, I do not feel any ADDED energy. So I guess my energy level was the same today as yesterday. I will not dose tomorrow and will dose the day after that, and report back. Grunt out.
 
bioman said:
How's everyone's allergies?

Mine are pretty much non-existent unless I forget to dose for a week or more. It is peak allergy season here in AZ.
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Over the weekend I heard the weatherman say that allergies were as bad as they get. I felt fine. I don't have severe allergies, but I do have them, and it has led to a couple of ear and sinus infections. I thought my sense of smell was gone from the infections, but it seems to be better than it has been in a long time.

BTW, my female hamster has also begun B12 therapy. She was quite chipper immediately after .3ml in the booty.
 
Beowulf said:
Over the weekend I heard the weatherman say that allergies were as bad as they get. I felt fine. I don't have severe allergies, but I do have them, and it has led to a couple of ear and sinus infections. I thought my sense of smell was gone from the infections, but it seems to be better than it has been in a long time.

BTW, my female hamster has also begun B12 therapy. She was quite chipper immediately after .3ml in the booty.
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I bet that was fun helping administer the dose to her booty. :lol:

I think next month Ill buy some of this, I have lots of insulin needles still around, 30g, 1/2 inch a believe, or w/e standard size was (left over from igf-1). Ive been looking for something to give some good clean energy that is relatively easy, and the allergy thing is a big plus.
 
Beowulf said:
Are you saying you aren't noticing any effects (on your animals)? Or are you just saying that the benefits have reached their peak and have stabilized?

IM is probably a good idea if dosing less often.
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I'm sorry. I should have been more clear. Have been IM meB12 for test subject #1 for aprox 20 days. Started @ 600mcg and quickly shifted to 1000mcg ED. During this time have tried a couple forays into subQ hoping to cut down on ED and go to EOD or E3D. But, lost too much of the benefits, and had to return to IM ED in order to regain the full effect. A lessoning of benefits has been noted, so perhaps at some point venture away from ED may be possible.

Other test subjects: have varied from 600mcg to 1000mcg and varied dose schedule, but not tried subQ. Results from these subjects has been that: 1000mcg IM ED seems to be the most effective.

A sure way to tell if meB12 is working after a time, or to what degree, skip a day of two, then re-inject test subject. You may be surprised at the results.
 
The female received 500mg today. Shortly after she was running around with an expression of "wow! this stuff is amazing".
 
so has anyone come to any kind of conclusion on IM vs. Sub-Q?!

going to start today around 1:00pm probably 500Mcg. guess i will go sub-q in the lower ab or booty not sure...
 
Doesn't seem to matter, but intuitively the IM is going to hit you faster and not last as long as SQ.

It's interesting to see the various reactions, which I would say depend heavily on how deficient the subject was prior to injection. Females are often low on B12/folic acid/iron. I would add folic acid or a multi B for those of you running this ED..you don't want you B vitamin status to get too far out of wack. Folic acid/B12 work together to boost hematocrit as well.
 
bioman said:
Doesn't seem to matter, but intuitively the IM is going to hit you faster and not last as long as SQ.

It's interesting to see the various reactions, which I would say depend heavily on how deficient the subject was prior to injection. Females are often low on B12/folic acid/iron. I would add folic acid or a multi B for those of you running this ED..you don't want you B vitamin status to get too far out of wack. Folic acid/B12 work together to boost hematocrit as well.
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So Bio, you think an oral Multi B vitamin might help (beyond a regular multivitamin)? The female hampster is already taking folic acid, as her vet said she was deficient. She is really happy with the B12. Today is a miserable, lethargic, rainy day in Boston, and both the male and the female subjects are coping better than usual.
 
A good multi vit should do the trick. I take huge doses of folic acid, 3-4000 mcgs) as it works very well for alleviating depression and anxiety in some cases. Some studies show it to be on par with prescription meds.
 
Yes, today in Boston sucked and Mr Weatherman says to expect it to suck for days. I think I need this stuff...
 
SD1959 said:
Yes, today in Boston sucked and Mr Weatherman says to expect it to suck for days. I think I need this stuff...
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Yeah, it is going to suck through Saturday :blink:


I wonder if we're all having such a great reaction b/c we're all B12 deficient or if it is some specific action of the B12.
 
If you've ever used antibiotics, chances are you are b12 deficient. AntiB's not only reduce or destroy your intestinal flora but some of them can mess up your gut's intrinsic factor which allows for the absorption of B12 and other nutrients.

I used AntiB's heavily as child and a teen for acne control. In my early teens I started to get allergies and by age 17 I was a complete mess. An allergist told me my sinuses were the worst he had ever seen. I had severe allergies, even with medication, up until I started using b12 and magnesium asporotate. I also had severe depression.

Anecdotal certainly, but I personally link those problems with B12 deficiency.
 
Interestingly, sinus infections due to allergies have led to most of the antibiotics I've taken. Good info.

I HEART B12!
 
The female test subject was complaining today of painful injection. It wasn't the pin, but the B12 entering that caused the pain. Soreness persisted for a while after. It was a shot to the posterior quadrant with a 1/2" slin pin filled with .5ml. Any thoughts on the pain? Even if it didn't go IM b/c of the booty, I wouldn't think a sub-Q shot should be that sore.
 
Beowulf said:
The female test subject was complaining today of painful injection. It wasn't the pin, but the B12 entering that caused the pain. Soreness persisted for a while after. It was a shot to the posterior quadrant with a 1/2" slin pin filled with .5ml. Any thoughts on the pain? Even if it didn't go IM b/c of the booty, I wouldn't think a sub-Q shot should be that sore.
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Sub-Q can sometimes be more painful than IM depending on the subject's underskin sensitivity to the preservatives.

I have skipped dosing for one day, then injected 1000mcg again but no positive effect was felt. I will now skip today and tomorrow and pin again on staturday, see if that works. :)
 
Yeah, it can sting for either style of injection. I think sometimes it depends on how close you pinned to a nerve.
 
I just wanna say Thanks for this thread. I had never really understood or really believed the use of B12 could be so beneficial. After reading this thread for a week I decided to order some.

The difference in my life is amazing. I've been a vegetarian for about 9 years now and after taking that first shot I'm pretty damn sure that i've been B12 deficient for a while now. My energy is up markedly and my mental clarity is at a level it hasn't been at for years. Thanks again, and thanks IBE.

Bannock
 
I agree bro. I've suffered depression and lethargy for my whole life. I'm able to conquer it through will on most occassions, but it is frustrating. Little things should not be as hard to do as they generally have been in the past. My posts may seem exaggerated, but I am 100% serious.

Special thanks to Bio (1st person I know of to talk about this) and Grunt.
 
Vegans are classically deficient in B12 and other nutrients like magnesium.

If you are depressed, seriously consider adding extra folic acid, selenium, and chromium in to your supps. If those don't cure it 100%, try colloidal gold..that stuff rocked my world and still does.
 
shot 500mcg MB12 after several days without it....marked difference in energy, focus and mood.

how does one find out of they are in fact B12 deficient? i'm sure there's a test that can be done...

i personally think the glute is the worst possible place to inject a 1/2" pin...good chance that you'll only hit the fat layer, and from what i've read, B12 wont do anything there as it is water-based and slow to absorb to boot.

try calves or tris or delts (pretty meaty spots on most female test subjects)
 
I have found one of the best sq areas is the stomach. No one wants to get a shot there but after its over they agree it is the best spot. Usually, no matter how lean you are they lower abdomen has some sq tissue. I think too by manipulating the angle of the needle with the appropriate body fat makes more sense.

Somtimes if you get too much of the drug on the needle itself it causes more pain b/c the drug infiltrates in the passage of the needle.

I know for the im shots they alleviate this infiltration by using a z-track method where the skin is rolled away and then injected. When you let go,the skin goes back and seals the meds into the muscle where it stays.

Air in needles is not a big deal but you should try to avoid it at all costs. IV's get small air bubbles in the line but it's no big deal. The only place you would be concerned about air is hitting a large femoral artery or something like that. Most of the im arteries are really small arterioles that are very numerous so you can bleed but an air embolism is close to non existent. There is always the exception but I have never heard of it.

I plan on pinning tommorow am before I go to work. I am going to load up like some have suggested. I am going to start with 500 mcg and see how that works.
 
I did a subq shot in the abdomen. It was definitely painless and easy. Slin pins are so small that I doubt it would hurt anywhere. I'm gonna start trying my bis.
 
It may be a bit late to be asking this, but are you all refrigerating your b12? I read on some hit from a google search that it must be refrigerated. That was the only mention I've seen. IBE didn't mention it, nor did temp. seem to be a big deal in shipping.
 
Geez, I hope not. I've been keeping it at room temp...in the dark because it does photodegrade.
 
This may account for my failures with subQ.
From: Invalid Link Removed
The injection must be given in the subcutaneous fat of the buttocks. Other "fat" areas, ie. abdomen, deltoids (shoulder) do not give the same effect. A 30 degree angle or less is best and will ensure that the medicine is not given in the muscle.
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For IM the shoulders have proven most effective with my test subjects so far.
 
Interesting link. I wonder if the fact that that is for kids on the autistic spectrum has any relevance. The doses also seem to be a ****load lower.
 
Beowulf said:
Interesting link. I wonder if the fact that that is for kids on the autistic spectrum has any relevance. The doses also seem to be a ****load lower.
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About the doses used in the article: it is actually higher. For a 150 lb individual they are recommending administering 4,515 mcg per injection every 3 days.
The dose is based on your child's weight in kilograms. Weight in pounds divided by 2.2 equals weight in kilograms (150 lbs ¸ 2.2 = 70 kg). The dose of MB-12 is 64.5 mcg x Kg. 64.5 mcg x 70 kg = 4,515 mcg per dose. Rounded off becomes 4,500 mcg per pre-filled syringe.
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At 1000 mcg a day for my lab rats, that is only 3,000 mcg total over 3 days, so their dosing quite a bit higher. It should also be pointed out that their solution is much higher at 25mg/ml., while IBE's is 1mg/ml. The higher concentration allows them to inject a much smaller volume and it dissipates into the system slower (having much less surface area).
 
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