Long story short, my SHBG is very very high. My doc tried me on clomid, which made me a wreck. He now wants me to give it another go, but with arimidex. I don't have real recent baseline labs, as the provincial labs are refusing to complete most tests at the moment. As such, I am uncertain where my estroidal is, which is less than ideal. Anyway, 7 days @ 25mg clomid per day and 1 mg arimidex (2 times per week) and I am a wreck again. Anxiety through the roof. Frankly, the arimidex is a pretty healthy dose. However, in dropping the clomid, I start to feel better within a few days, which makes me wonder if the the side effects I get from clomid are independant from estroidal being elevated. My question is, has anyone tried this combination and had elevated SHBG in spite of estroidal being in check? Also, is flat out TRT a more practical route in the face of elevated SHBG. I can't get proviron here, otherwise I'd try it.