Meth, cocaine and Glp-1 agonists. 🤯🤯🤯

[Smont]

Don't do drugs, let's just start here lol.

I made this thread looking for some people to chime in hopefully how understand these drugs way better then I do.

The first glp1-A that everyone has heard of is probably ozempic, it works, but ozempic only killing appetite and lowering blood sugar. Now we have retatrutide and some others that do the same while also directly effect fat loss.

I never liked the idea of trying to give overweight people who probably don't understand the importance of diet a drug that only kills hunger because the gods honest truth of the matter is that many of these ppl will basically start only eating a few tasty treats and not much real food. They loose weight in a extremally unhealthy malnourished nutrition lacking way. And this is where we see the horror pictures that people blame on ozempic when ozempic has nothing to do with it, the real reason is it's basically like if I was to cut on 1000 cal a day and used that 1000 cal for a burger and a milkshake every day. That might even be healthier than what I've had ppl tell me there diet was like.

This got me going down the rabbit hole of wanting to learn something new, coupled with ADHD, and old memories.

I knew/now tons of people with drug issues. The daily drug users are usually skinny and do not have much actual muscle which is expected. These cns stimulants like coke and meth all suppress appitate by acting on the part of your brain that controls hunger and they also all lower your blood glucose. Some do right away and others do over time.

Wouldn't these technically be (dangerous) but Glp-1 agonists.

They increase Catecholamine which in turn dramatically effects carbohydrate metabolism by slowing down insulin secretion and this increases the production of glucagon. That's also how a glp-1 works! The same thing, but obviously not the same thing....

Now before someone chimes in and tells me not to use drugs lol. I don't use any alcohol or drugs, outside of pot and performance enhancement drugs. I'm not interested in using coke or a glp-1 for myself .

I'm just curious on the topic.

 

[gphagan1]

Don't do drugs, let's just start here lol.

I made this thread looking for some people to chime in hopefully how understand these drugs way better then I do.

The first glp1-A that everyone has heard of is probably ozempic, it works, but ozempic only killing appetite and lowering blood sugar. Now we have retatrutide and some others that do the same while also directly effect fat loss.

I never liked the idea of trying to give overweight people who probably don't understand the importance of diet a drug that only kills hunger because the gods honest truth of the matter is that many of these ppl will basically start only eating a few tasty treats and not much real food. They loose weight in a extremally unhealthy malnourished nutrition lacking way. And this is where we see the horror pictures that people blame on ozempic when ozempic has nothing to do with it, the real reason is it's basically like if I was to cut on 1000 cal a day and used that 1000 cal for a burger and a milkshake every day. That might even be healthier than what I've had ppl tell me there diet was like.

This got me going down the rabbit hole of wanting to learn something new, coupled with ADHD, and old memories.

I knew/now tons of people with drug issues. The daily drug users are usually skinny and do not have much actual muscle which is expected. These cns stimulants like coke and meth all suppress appitate by acting on the part of your brain that controls hunger and they also all lower your blood glucose. Some do right away and others do over time.

Wouldn't these technically be (dangerous) but Glp-1 agonists.

They increase Catecholamine which in turn dramatically effects carbohydrate metabolism by slowing down insulin secretion and this increases the production of glucagon. That's also how a glp-1 works! The same thing, but obviously not the same thing....

Now before someone chimes in and tells me not to use drugs lol. I don't use any alcohol or drugs, outside of pot and performance enhancement drugs. I'm not interested in using coke or a glp-1 for myself .

I'm just curious on the topic.

That’s actually an interesting theory and makes sense…..and obviously the National Institute Health (NIH) thinks so too, because it appears they are looking into research to use glp-1 to help Cocaine addicts kick the addiction.

Central GLP-1 Receptors: Novel Molecular Targets for Cocaine Use Disorder - PMC

Given that the search for effective pharmacotherapies for cocaine use disorder has, thus far, been fruitless, there remains a critical need for conceptually innovative approaches toward identifying new medications to treat this disease. A better ...

pmc.ncbi.nlm.nih.gov

 

[sns8778]

The way this appeared on the sidebar as a new thread - my first thought was - Dang, Smont is taking his next cutting cycle seriously lol

 

[PolishHamm3r77]

It won’t work the same. Most people binge. So you won’t eat for a couple days, then you sleep and wake up hungry AF and eat a ton of dirty cals and gain weight. And we all know that when sleep deprived cals r stored as fat before anything else. Clean cals are even not partitioned correctly when sleep deprived. I am not proud to admit but I’d be the equivalent of Hyde on this topic. I had a 2 into 1 intake for several years(deviated septum). Many case studies under my belt between 2004 and 2010 and resumed research from 2015(last time I disappeared from here) until 2019. I don’t plan on conducting any more research it was all self funded. I didn’t have a grant

 

[Jbryfit1]

The way this appeared on the sidebar as a new thread - my first thought was - Dang, Smont is taking his next cutting cycle seriously lol

Same. Had to click when I saw his name.

 

[Smont]

The way this appeared on the sidebar as a new thread - my first thought was - Dang, Smont is taking his next cutting cycle seriously lol

It's 4am and I just burst out laughing. I didn't think how that would read. It sounds like I'm laying out my cycle

 

[Smont]

That’s actually an interesting theory and makes sense…..and obviously the National Institute Health (NIH) thinks so too, because it appears they are looking into research to use glp-1 to help Cocaine addicts kick the addiction.

Central GLP-1 Receptors: Novel Molecular Targets for Cocaine Use Disorder - PMC

Given that the search for effective pharmacotherapies for cocaine use disorder has, thus far, been fruitless, there remains a critical need for conceptually innovative approaches toward identifying new medications to treat this disease. A better ...

pmc.ncbi.nlm.nih.gov

That's pretty cool, I will check this out

 

[cheftepesh1]

That was an interesting read. I have some colleagues that would be interested in this.

 

[kisaj]

That’s actually an interesting theory and makes sense…..and obviously the National Institute Health (NIH) thinks so too, because it appears they are looking into research to use glp-1 to help Cocaine addicts kick the addiction.

Central GLP-1 Receptors: Novel Molecular Targets for Cocaine Use Disorder - PMC

Given that the search for effective pharmacotherapies for cocaine use disorder has, thus far, been fruitless, there remains a critical need for conceptually innovative approaches toward identifying new medications to treat this disease. A better ...

pmc.ncbi.nlm.nih.gov

I mean, it makes sense. This is largely due to the rapid increase in dopamine, which other substances also cause at a different level. It seems that all GLPs are doing is taking away the reward from the release of dopamine- similar to NAC, in some regard. Thus reducing the craving, but I would also think overall mood. I mean, they've been looking at GLPs to help alcohol abuse as well, which would work in the same way.