Meth, cocaine and Glp-1 agonists. 🤯🤯🤯

[Smont]

Don't do drugs, let's just start here lol.

I made this thread looking for some people to chime in hopefully how understand these drugs way better then I do.

The first glp1-A that everyone has heard of is probably ozempic, it works, but ozempic only killing appetite and lowering blood sugar. Now we have retatrutide and some others that do the same while also directly effect fat loss.

I never liked the idea of trying to give overweight people who probably don't understand the importance of diet a drug that only kills hunger because the gods honest truth of the matter is that many of these ppl will basically start only eating a few tasty treats and not much real food. They loose weight in a extremally unhealthy malnourished nutrition lacking way. And this is where we see the horror pictures that people blame on ozempic when ozempic has nothing to do with it, the real reason is it's basically like if I was to cut on 1000 cal a day and used that 1000 cal for a burger and a milkshake every day. That might even be healthier than what I've had ppl tell me there diet was like.

This got me going down the rabbit hole of wanting to learn something new, coupled with ADHD, and old memories.

I knew/now tons of people with drug issues. The daily drug users are usually skinny and do not have much actual muscle which is expected. These cns stimulants like coke and meth all suppress appitate by acting on the part of your brain that controls hunger and they also all lower your blood glucose. Some do right away and others do over time.

Wouldn't these technically be (dangerous) but Glp-1 agonists.

They increase Catecholamine which in turn dramatically effects carbohydrate metabolism by slowing down insulin secretion and this increases the production of glucagon. That's also how a glp-1 works! The same thing, but obviously not the same thing....

Now before someone chimes in and tells me not to use drugs lol. I don't use any alcohol or drugs, outside of pot and performance enhancement drugs. I'm not interested in using coke or a glp-1 for myself .

I'm just curious on the topic.

 

[gphagan1]

Don't do drugs, let's just start here lol.

I made this thread looking for some people to chime in hopefully how understand these drugs way better then I do.

The first glp1-A that everyone has heard of is probably ozempic, it works, but ozempic only killing appetite and lowering blood sugar. Now we have retatrutide and some others that do the same while also directly effect fat loss.

I never liked the idea of trying to give overweight people who probably don't understand the importance of diet a drug that only kills hunger because the gods honest truth of the matter is that many of these ppl will basically start only eating a few tasty treats and not much real food. They loose weight in a extremally unhealthy malnourished nutrition lacking way. And this is where we see the horror pictures that people blame on ozempic when ozempic has nothing to do with it, the real reason is it's basically like if I was to cut on 1000 cal a day and used that 1000 cal for a burger and a milkshake every day. That might even be healthier than what I've had ppl tell me there diet was like.

This got me going down the rabbit hole of wanting to learn something new, coupled with ADHD, and old memories.

I knew/now tons of people with drug issues. The daily drug users are usually skinny and do not have much actual muscle which is expected. These cns stimulants like coke and meth all suppress appitate by acting on the part of your brain that controls hunger and they also all lower your blood glucose. Some do right away and others do over time.

Wouldn't these technically be (dangerous) but Glp-1 agonists.

They increase Catecholamine which in turn dramatically effects carbohydrate metabolism by slowing down insulin secretion and this increases the production of glucagon. That's also how a glp-1 works! The same thing, but obviously not the same thing....

Now before someone chimes in and tells me not to use drugs lol. I don't use any alcohol or drugs, outside of pot and performance enhancement drugs. I'm not interested in using coke or a glp-1 for myself .

I'm just curious on the topic.

That’s actually an interesting theory and makes sense…..and obviously the National Institute Health (NIH) thinks so too, because it appears they are looking into research to use glp-1 to help Cocaine addicts kick the addiction.

Central GLP-1 Receptors: Novel Molecular Targets for Cocaine Use Disorder - PMC

Given that the search for effective pharmacotherapies for cocaine use disorder has, thus far, been fruitless, there remains a critical need for conceptually innovative approaches toward identifying new medications to treat this disease. A better ...

pmc.ncbi.nlm.nih.gov

 

[sns8778]

The way this appeared on the sidebar as a new thread - my first thought was - Dang, Smont is taking his next cutting cycle seriously lol

 

[PolishHamm3r77]

It won’t work the same. Most people binge. So you won’t eat for a couple days, then you sleep and wake up hungry AF and eat a ton of dirty cals and gain weight. And we all know that when sleep deprived cals r stored as fat before anything else. Clean cals are even not partitioned correctly when sleep deprived. I am not proud to admit but I’d be the equivalent of Hyde on this topic. I had a 2 into 1 intake for several years(deviated septum). Many case studies under my belt between 2004 and 2010 and resumed research from 2015(last time I disappeared from here) until 2019. I don’t plan on conducting any more research it was all self funded. I didn’t have a grant

 

[Jbryfit1]

The way this appeared on the sidebar as a new thread - my first thought was - Dang, Smont is taking his next cutting cycle seriously lol

Same. Had to click when I saw his name.

 

[Smont]

The way this appeared on the sidebar as a new thread - my first thought was - Dang, Smont is taking his next cutting cycle seriously lol

It's 4am and I just burst out laughing. I didn't think how that would read. It sounds like I'm laying out my cycle

 

[Smont]

That’s actually an interesting theory and makes sense…..and obviously the National Institute Health (NIH) thinks so too, because it appears they are looking into research to use glp-1 to help Cocaine addicts kick the addiction.

Central GLP-1 Receptors: Novel Molecular Targets for Cocaine Use Disorder - PMC

Given that the search for effective pharmacotherapies for cocaine use disorder has, thus far, been fruitless, there remains a critical need for conceptually innovative approaches toward identifying new medications to treat this disease. A better ...

pmc.ncbi.nlm.nih.gov

That's pretty cool, I will check this out

 

[cheftepesh1]

That was an interesting read. I have some colleagues that would be interested in this.

 

[kisaj]

That’s actually an interesting theory and makes sense…..and obviously the National Institute Health (NIH) thinks so too, because it appears they are looking into research to use glp-1 to help Cocaine addicts kick the addiction.

Central GLP-1 Receptors: Novel Molecular Targets for Cocaine Use Disorder - PMC

Given that the search for effective pharmacotherapies for cocaine use disorder has, thus far, been fruitless, there remains a critical need for conceptually innovative approaches toward identifying new medications to treat this disease. A better ...

pmc.ncbi.nlm.nih.gov

I mean, it makes sense. This is largely due to the rapid increase in dopamine, which other substances also cause at a different level. It seems that all GLPs are doing is taking away the reward from the release of dopamine- similar to NAC, in some regard. Thus reducing the craving, but I would also think overall mood. I mean, they've been looking at GLPs to help alcohol abuse as well, which would work in the same way.

 

[Pin2Win117]

The way this appeared on the sidebar as a new thread - my first thought was - Dang, Smont is taking his next cutting cycle seriously lol

 

[Smont]

Bump: did anyone survive the cocaine and meth cycle? In for feedback lol

I bumped this thread because I'm interested to see if anybody has switched from Semaglutide (I don't like anything about sema) but is anyone switched from semi to a Natty glp 1 and what was your results?

Also I'm getting very interested in reta if anyone has feedback, particularly in low 1-2mg per week doses?

I'm only looking for personal experiences, I'm not interested in any I heard or I read or I saw type stuff. I can handle the research part I just am looking for people's first hand experiences

 

[GQdaLEGEND]

i know some peeps, who knows some peeps who knows some .. oh wait your not interested

jk jk i have no feedback on topic .. i do like your opening line in this thread and agree drugs are bad lol

 

[ironviking]

I'm on Mounjaro (Tirzepatide), I am a Type1 diabetic so the prescription is a bit off label. This was after a long period ~14yrs of a sedentary lifestyle, I was a competitive gym rat before then. I ran into some serious health issues and decided to get healthy again. I was already losing weight pretty well but my BGs starting fluctuating drastically (due to weight loss). With the other health issues I had my doc and I decided to go with a low dose script to see if that would help even things out a bit. I will say right now that if anyone says that anything over the counter or even illicit drugs have the same appetite killing effect they haven't taken the full range of drugs and compared them to Tirz. The day after taking 2.5mg my appetite was gone completely. I've never had a high hunger drive so losing weight for me was sometimes a struggle but nothing horrifically bad but on this stuff there is no hunger drive, I didn't even think about food and could go for days without eating...and did a couple times. This led to some malnutrition and dehydration so I set reminders to eat and drink. I really think this is where a lot of people run into problems, they don't eat and/or drink properly to support their nutritional needs; it's very easy to do. This wasn't bad at first because I was just trying to get healthy again and not build muscle.
Finally got back into the gym and after a few months decided to do a light bulk, it was darn near impossible and I was only taking 5mg at this time. So I decided to come off of it, at least for a bit. The effects lingered for about 5 weeks after the last injection, my hunger returned but it was lower than it had originally been. My taste had changed as well, I no longer craved any sweets, and still don't. My cravings were more toward healthier foods, peppers, mushrooms, salads, fruit, lean protein sources, et. cetera. Caffeine had a much stronger effect as well, one cup of coffee gives me jitters...and I can't stand the taste anymore - I used to drink coffee all day long.
After the bulk I decided to go back on because again my BGs were bouncing around too much and Tirz did help to even them out. I decided to jump right back into 5mg, big mistake, I slept for like two days straight after the first two injections, finally after the 3rd week I adjusted to the dose. Again, hunger completely gone - no hunger pangs, no denying food, you just don't think about food.
It's easy to start making healthier choices with that craving for dopamine gone, it saddens me that so many people on this stuff don't take advantage of that.
to summarize
Hunger - completely knocks it out up to the point where a person may have to force themselves to eat.
Blood sugar - nothing except insulin lowers it better and this is coming from a type1 diabetic. My total daily dose of insulin is around 25units now where it used to be over 70 (partially due to weight loss also)
Weight loss - Tirz has helped me lose over 60lbs of fat. As stated I was already on a path to get healthier and lost around 20lbs before starting Tirz but it rapidly sped the weight loss process up.
For the natty GLP-1 agonist pffft I tried them during bulking when I was off Tirz and they just don't compare. I even tried high doses of berberine and it doesn't come close. And these fools that say berberine lowered their fasting glucose by 5 points....that's well within the range of variation with the tests. If it were around 20points it might be something to look at but anything under that could be due to natural variables.
I have been looking at reta but insurance is picking up the tab for my script right now so if that changes I'll probably give reta a try. I wouldn't bother with sema, Tirz is a dual agonist (GLP-1 and GIP), and reta is a triple agonist (GLP-1, GIP, and Glucagon receptors), sema is just a GLP-1 agonist.

 

[ironviking]

Damn I freakin rambled on there. Here's what you were asking about:

For the natty GLP-1 agonist pffft I tried them during bulking when I was off Tirz and they just don't compare. I even tried high doses of berberine and it doesn't come close. And these fools that say berberine lowered their fasting glucose by 5 points....that's well within the range of variation with the tests. If it were around 20points it might be something to look at but anything under that could be due to natural variables.

 

[SkRaw85]

Bump: did anyone survive the cocaine and meth cycle? In for feedback lol

I bumped this thread because I'm interested to see if anybody has switched from Semaglutide (I don't like anything about sema) but is anyone switched from semi to a Natty glp 1 and what was your results?

Also I'm getting very interested in reta if anyone has feedback, particularly in low 1-2mg per week doses?

I'm only looking for personal experiences, I'm not interested in any I heard or I read or I saw type stuff. I can handle the research part I just am looking for people's first hand experiences

Family member was running sema (end dose 2.5mg) switched to Reta a few months ago with nothing but good things to say/show. Reta dose has been 2mg throughout. Sema would give a crippling nausea feeling which would detract from hunger, Reta does not create this feeling. It eliminates “hunger noise” and enables the ability to simply switch of hunger, in a much more streamlined way. Glucagon is a fun research rabbit hole.

 

[SkRaw85]

Forgot to mention GLP-1 eliminated nicotine use with this person, starting with sema.

 

[Smont]

Damn I freakin rambled on there. Here's what you were asking about:

I like the details it's fine. I'm actually less concerned about the appitate blunting effect, I know Reta and the natural options are less dramatic on blunting appitate but offer some better fat loss results through different pathways and seem to improve health markers. With sema, it's just a lot of appitate suppression and I deal with weight loss clients mostly, they often can't put the fork down, and I also binge eat myself but I normally can pick and choose my battles, normally...

The issue I found with sema, which I initially was worried about, ended up being tru for a lot of the ppl I know who tried it. You take a person who's close to 100 lb overweight and probably eats 4000 calories a day while sitting on the couch, and then you take their appetite away, and now they only have room for about a thousand calories and they tend to make poor food choices with it which leads to you not being very healthy and bad body composition, but even when their diet is on track when they come off and you reintroduce that hunger signal, they can't control it. This isn't everyone, just some things I was worried about that I saw happening first hand.

With the natty ones there's less of a blunting effect and Im looking to use it as a tool for the bigger picture. Rotation between low dose Reta and natty glp1's and I like them to incorporate drinking some green tea instead of raising the doses. I'm not really painting the full picture because it's a work in progress, but here's what I'm thinking, and I'm going to apply it to myself at some point .

Il lay out my thoughts/protocol ideas in the next post so it's not endless post

 

[Smont]

So this is in its infantry, and it's just me getting creative, cost effective and my focus is results driving. And I'm usually more concerned with body composition than actual weight loss. I'm not trying to starve anyone, I'm trying to supplement there nutrition and training and lifestyle choices.

Insert Angelo, Currently 247lbs and I'm assuming we're going to cut to about 200. He's already lost about 25 lb and he's starting to struggle and he went for ozempic and it made him sick and not actual able to finish his already low calorie meal plan so I had him dump it for 1mg Reta in its place.

2 weeks on 1mg and he's doing really good, when he started getting little extra bursts of hunger I tell him to go drink 2 cups of green tea and see if your still hungry after, so far it's working 3 out of 4 times. We noticed it immediately blunt your appetite but the effects don't last that long, but it does seem to last long enough to get him to his next meal no problem, he's just sometimes hungry when anticipating that next meal but he can deal with it. Only rule right now is green tea to help no more then once a day. Because I think it's going to be important to leverage the green tea more when we break.

The plan is to go up to 2 mg when needed and after 2 weeks at 2mg were taking a break. The plan is to stop reta, use the OTC glp, probably going with Steve's because that's got feedback here on the board and I trust his supplement knowledge, but we're going to rotate that in and then we really use the green tea as a extra bit of appitate suppression between each meal. He came off his metformin with Reta and will put it back in with lean glp and the green tea.

After 2 weeks were going back to 1mg Reta and take notes. The plan is every time 2 mg seems like it's not enough we take a little break and calories might even get a small increase during those two weeks I can increase their cardio to balance out the little bit of extra food, they get the benefits of a little appitate suppression and some direct fat burning ingredients and also, GLP's are EXPENSIVE AS ****! The break will save money by using less reta with lean glp, green tea and his metformin during the break and maintenance phases.

I type this up and did a little bit of it talk to text while I was working on some other projects so if I got off track anywhere I apologize.

@ironviking your post was very helpful. It actually makes me a little more confident in my ideas.

And of course I'm doing this around his diet and training, that's always (well, almost always) a constant. Everybody has screw ups

 

[Paintball26]

Bump: did anyone survive the cocaine and meth cycle? In for feedback lol

I bumped this thread because I'm interested to see if anybody has switched from Semaglutide (I don't like anything about sema) but is anyone switched from semi to a Natty glp 1 and what was your results?

Also I'm getting very interested in reta if anyone has feedback, particularly in low 1-2mg per week doses?

I'm only looking for personal experiences, I'm not interested in any I heard or I read or I saw type stuff. I can handle the research part I just am looking for people's first hand experiences

Chiming in a bit late, but I was a Sema user and had the same stomach issues on lower dosages. I toughed it out for a while, but Sour stomach/Heartburn absolutely destroyed my sleep for the 36-48 hours after dosing for the first couple months until I finally would just semi force myself to get sick once and it'd end until the next dosing. So needless to say, I never really upped the dosage and my workouts definitely suffered.
Fiance never had the issue.

Switched to 2mg Reta about 2 months ago and it's a night and day difference with me having none of the sides. Fiance loves it as well, but takes ~1.25mg/wk.
Only real side effect I've noticed is maybe a bit of brainfog/spaciness the day after dosing where I'm functioning at 90% mentally, so I take it Saturdays to make sure my off day is Sunday to not interfere with work.

Had similar stats to the client you referenced above after becoming a Workaholic WFH Lawyer, so my real goal was getting rid of the food noise and reestablishing a healthy relationship with my diet. Still get meal prep delivered weekly, but I started that before the drugs to eliminate my laziness of ordering ubereats and having a rotating variety of meals available.

Interested in how the program you outlined above is coming along as I've been thinking of using the OTC options on my eventual ween off phase of using the lowest effective dose.

 

[Smont]

Chiming in a bit late, but I was a Sema user and had the same stomach issues on lower dosages. I toughed it out for a while, but Sour stomach/Heartburn absolutely destroyed my sleep for the 36-48 hours after dosing for the first couple months until I finally would just semi force myself to get sick once and it'd end until the next dosing. So needless to say, I never really upped the dosage and my workouts definitely suffered.
Fiance never had the issue.

Switched to 2mg Reta about 2 months ago and it's a night and day difference with me having none of the sides. Fiance loves it as well, but takes ~1.25mg/wk.
Only real side effect I've noticed is maybe a bit of brainfog/spaciness the day after dosing where I'm functioning at 90% mentally, so I take it Saturdays to make sure my off day is Sunday to not interfere with work.

Had similar stats to the client you referenced above after becoming a Workaholic WFH Lawyer, so my real goal was getting rid of the food noise and reestablishing a healthy relationship with my diet. Still get meal prep delivered weekly, but I started that before the drugs to eliminate my laziness of ordering ubereats and having a rotating variety of meals available.

Interested in how the program you outlined above is coming along as I've been thinking of using the OTC options on my eventual ween off phase of using the lowest effective dose.

I'm not seeing anyone have issues when we take out the Reta. But we are also focused on eating good and keeping calories at a reasonable amount. I made changes with everyone, but I didn't make the same changes with everyone some ppl are at 3-4,mg, no1 exceeded 4mg. The general outlet this seems to work for my clients. 1-2mg and we're using green tea, black coffee and kombucha. I put some extra fiber, pre-pro biotics and some fermented foods in there diet. The one person on higher doses is the only person who constantly misses there meals and doesn't supplement the things I mentioned because they don't like tea, coffee or kombucha and this person is regularly my only problem lol.

Basically I have them using reta (over sema)for health reasons and mild appitate suppression is the bonus. We use the other stuff (limited amounts)I mentioned to help keep the dose at 2mg, and when we break, we are increasing the green tea or kombucha or whatever to pick up the slack. Increase fiber, add a little extra cardio for those 2ish weeks and start back at 1mg again. Because Reta has a 7 day half life, after 2 weeks off Reta, there's still some of the drug in you, so when you start back up again you're always on a little bit higher dose than you were previously.

Something interesting that someone is trying on there own doing. I mentioned Reta has a 7 day half life, that means it's actually about 35 days to totally clear out. So one of them is taking 2mg every other week and they up the green tea on week 2. Week 3 they take another 2mg and so on. He's a sample pool of 1 and he has good willpower so I wouldn't say he's a guideline and is just a outlier right now

 

[Stacks1]

I didn't read the thread but it sure sounds like one hell of a stack! Would be interested in reading the review of anyone who might have survived this.