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M1T chemistry/biology related question

SpecialK117

Member
The suggested dosage for M1T is 10mg ED. Some have used more and some have used less, but it seems a lot have gained on 10mg from what I've read. My question is: how does only 10mg of 1-test ED produce such dramatic gains? The human body only produces 4-10mg of natural test ED (taken from a pubmed article), so how does a dose of 1-t that is so close to the body's own level of test production produce such dramatic results? Is there some reaction taking place that converts the 1-t into a much larger quantity of an active substance or something?
 
first off 1-test is NOT test nor does it convert to it
secondly methylated 1-test (m1t) isn't 1-test the methylation changes the entire compound
 
Methylation of any steroid is going to require a smaller dose to see effectiveness. That' the whole point. You are comparing apples and oranges here. Think of d-bol, and boldenone.
 
ryansm said:
Methylation of any steroid is going to require a smaller dose to see effectiveness. That' the whole point. You are comparing apples and oranges here. Think of d-bol, and boldenone.
Click to expand...
Yes but test produced by your body is 100% bioavailable. What is it about the m1t compound that makes it require such a smaller effective dose, beyond just the fact that it is methylated? On the other hand, more 1-test is required if injected than regular test.
 
you're totally missing the point

1-test is a COMPLETELY DIFFERENT HORMONE/COMPOUND than testosterone

they aren't the same thing
 
M1t is far more anabolic than testosterone is to the body, this is why it can produce profoundly greater effects at the same dosages, i do not know the biochemistry behind this though, or why it is more anabolic.
 
I wondered the same thing many times when I first started here...how can 10mg. of something illicit such drastic gains?

To answer your question, M1T is thought to be anywhere from 900-1200% more anabolic than testosterone. I can't go into a thorough explanation of how this occurs in-vivo, but basically it binds tightly to your androgen recpetors and doesn't breakdown b/c it's a methyl. A short read on anabolic biochemistry will explain the significance of the 900% number.
 
what everyone is saying is m1t is not the same as 1t so dont interchage the 2.
brodus covered it as well as I could. m1t is about 9X more powerful than testosterone. so I guess you can say its like about 10 mg of m1t is similar to taking 90 to 120 mg of testosterone. I'm not a scientist so that is broken down into very rough laymans terms.
 
Brodus said:
I wondered the same thing many times when I first started here...how can 10mg. of something illicit such drastic gains?

To answer your question, M1T is thought to be anywhere from 900-1200% more anabolic than testosterone. I can't go into a thorough explanation of how this occurs in-vivo, but basically it binds tightly to your androgen recpetors and doesn't breakdown b/c it's a methyl. A short read on anabolic biochemistry will explain the significance of the 900% number.
Click to expand...
Do you have any recommended sources for reading about anabolic biochem?
 
There are a few reasons that something like M1T might be more potent than T. I see this was briefly covered above but thought I might go into a little more detail.

First, the endogenous ligand isn't necessarily the strongest agonist at the receptor. In other words T itself may not activate whatever receptors are involved as strongly as some other chemical does. For instance people often say that DHT is stronger than T, at least in some cases.

Second, half life is very important. The half life of T is pretty short compared to the (supposed typical) half life of various methyls. This means that the methyls hang around a lot longer, which has the same net result for our purposes as upping the dose.

The scenario you mentioned, active metabolites, does occur in some cases. The drug might be metabolized into related chemicals which are also active. Some might even be more potent and/or have longer half lives. The best example I can think of here is in the benzodiazepine family, where this sort of thing definitely happens. As far as androgens, think of 4AD. It is said to be active on it's own, but in addition some fraction of it is definitely metabolized into T, which is also quite active. (I am not suggesting that this does or does not happen with M1T specifically, just saying that this type of scenario is something that can occur in some cases.)

This list is not exhaustive, but I think it covers the basics.
 
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