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Love of SNS / Mw1 <3

Very Nice !
 
Can any of the reps shed some light on piperine? As in, we ok taking 2 caps indefinitely? Im not too familiar with the ingredient other than what Coop has said about it regarding AMF...De_eB?
 
NewAgeMayan said:
Can any of the reps shed some light on piperine? As in, we ok taking 2 caps indefinitely? Im not too familiar with the ingredient other than what Coop has said about it regarding AMF...De_eB?
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I'm def not the expert but piperine is simply an absorption enhancer and is in almost every (or at least a ton of) supplement.... Can't see this being an issue at all.
 
booneman77 said:
I'm def not the expert but piperine is simply an absorption enhancer and is in almost every (or at least a ton of) supplement.... Can't see this being an issue at all.
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This!!

There is studies showing effectivity of piperine. Boosting bioavailability of many plant/herb compounds and not to mention medicines too..

Here is something to read:

How piperine increases the bioavailability of many substances:
Piperine has the remarkable ability to manipulate all four of these mechanisms. It inhibits a number of enzymes responsible for metabolizing drugs and nutritional substances; it stimulates the activity of amino-acid transporters in the intestinal lining; it inhibits p-glycoprotein, the ‘pump’ protein that removes substances from cells; and it decreases the intestinal production of glucuronic acid, thereby permitting more of the substances to enter the body in active form. Consequently, some of these substances are able to reach, enter, and remain within their target cells for longer periods of time than would otherwise be the case. Of course, this can be a mixed blessing – if one is using a drug for which the therapeutic level is not substantially lower than the toxic level, piperine supplementation might raise the bioavailability of the drug until its intracellular concentration exceeds the toxic threshold. On the other hand, piperine supplementation can sometimes turn a marginally effective therapeutic substance into a highly effective one simply by increasing its bioavailability and intracellular residency time. A good example of this latter phenomenon is the use of piperine to increase the bioavailability of curcumin, a supplement with broad activity against cancers, inflammation and infections. A 20 mg dose of piperine can increase curcumin’s bioavailability twentyfold.

Piperine and Viagra
The drug sildenafil (Viagra®) is metabolized mainly by the enzyme CYP3A4, which is found in many tissues, including the small intestine and the liver. Consequently, when one takes a dose of this drug, some of the dose is destroyed before it reaches the bloodstream, and more of it is destroyed in the liver before it reaches the rest of the body. About 40% of the sildenafil successfully reaches the general circulation. Once there, half of it gets metabolized every 4 hours during passes through the liver and other tissues. Thus, out of a 100 mg dose, about 20 mg remains in circulation after 4 hours.

Piperine, as indicated above, is an inhibitor of the CYP3A4 enzyme. If a dose of piperine is taken shortly before a dose of sildenafil, the sildenafil will not have to ‘run the gauntlet’ of CYP3A4 metabolism on its way to the bloodstream. This will boost the efficiency of a dose of sildenafil – potentially by as much as a factor of 2.5. This means that a 100 mg dose taken with piperine could be equivalent to a 250 mg dose taken without it – a dose likely to produce unpleasant side effects at the very least. Piperine will also prolong the action of sildenafil, probably by about two hours, which is how long the inhibition of CYP3A4 lasts in the liver.
 
Yip, its effects on certain compounds and whatnot are certinly impressive, but Im not so much concerned with them.

My query is dose related; is 40mg (2 caps) /day not too excessive if one wishes to do so longterm, and what about even higher amounts? I am completely ignorant as to the chronic (or even acute, to a certain extent) effects such dosing may or may not ellicit.
 
NewAgeMayan said:
Yip, its effects on certain compounds and whatnot are certinly impressive, but Im not so much concerned with them.

My query is dose related; is 40mg (2 caps) /day not too excessive if one wishes to do so longterm, and what about even higher amounts? I am completely ignorant as to the chronic (or even acute, to a certain extent) effects such dosing may or may not ellicit.
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I know for sure that common side with high piperine dose is GI issues .
And honestly, I would be carefull with to much piperine if using medicines
 
Danes said:
I know for sure that common side with high piperine dose is GI issues .
And honestly, I would be carefull with to much piperine if using medicines
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I hope it dosnt sound like Im trying to be a wiseguy or call anyone out?

If the official stance of SNS/CEL is "dont be such a greedy homo, Mayan, and stick to the suggested daily dose of 1 cap prewo you really dont need more than that" then cool, thats along the lines of what Im asking too :D
 
NewAgeMayan said:
I hope it dosnt sound like Im trying to be a wiseguy or call anyone out?

If the official stance of SNS/CEL is "dont be such a greedy homo, Mayan, and stick to the suggested daily dose of 1 cap prewo you really dont need more than that" then cool, thats along the lines of what Im asking too :D
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Lol.
 
NewAgeMayan said:
I hope it dosnt sound like Im trying to be a wiseguy or call anyone out?

If the official stance of SNS/CEL is "dont be such a greedy homo, Mayan, and stick to the suggested daily dose of 1 cap prewo you really dont need more than that" then cool, thats along the lines of what Im asking too :D
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Actually 1-2 pills are more than enough for health benefits,endurance etc:)

But I do understand your question about piperine dose. Not to mention if its taken 3-4 caps daily
 
NewAgeMayan said:
Yip, its effects on certain compounds and whatnot are certinly impressive, but Im not so much concerned with them.

My query is dose related; is 40mg (2 caps) /day not too excessive if one wishes to do so longterm, and what about even higher amounts? I am completely ignorant as to the chronic (or even acute, to a certain extent) effects such dosing may or may not ellicit.
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Itl be fine at 2 caps :D
 
Had an insane crazy weekend (wife was having contractions etc at 34 weeks-luckily they were able to stop our daughter from coming for the time being) so today I came home to a package that really lifted my spirits :) been eyeballing this epi-plex since I heard about it. I was and still am going to order a few more bottles (no doubt in my mind it will deliver) I will get a log up in a couple of days. thanks again mw1 and the entire sns/cel team. Made my day! Invalid Link Removed
 
Afi140 said:
Had an insane crazy weekend (wife was having contractions etc at 34 weeks-luckily they were able to stop our daughter from coming for the time being) so today I came home to a package that really lifted my spirits :) been eyeballing this epi-plex since I heard about it. I was and still am going to order a few more bottles (no doubt in my mind it will deliver) I will get a log up in a couple of days. thanks again mw1 and the entire and/cel team. Made my day! Invalid Link Removed
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Nice!! Most important I am glad you daughter & wife are OK.
 
thanks brotha-appreciate it.
 
aaronuconn said:
Who's this MW1 guy? Never heard of him.

:D
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he is like the Bruce (ooops i mean Caitlyn) Jenner of the supplement world. He is gonna break the twitter record ;)
 
Afi140 said:
Had an insane crazy weekend (wife was having contractions etc at 34 weeks-luckily they were able to stop our daughter from coming for the time being) so today I came home to a package that really lifted my spirits :) been eyeballing this epi-plex since I heard about it. I was and still am going to order a few more bottles (no doubt in my mind it will deliver) I will get a log up in a couple of days. thanks again mw1 and the entire sns/cel team. Made my day! Invalid Link Removed
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hey congrats to you and your wife-and good luck!!!

geez, that was fast, can't believe you got it already!!!!
 
Will be following your log. Best wishes for you and your family !!
 
mw1 said:
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those are tightttttt (that means cool for all the old folks floating around these parts-even though I feel way old teaching high schoolers)
 
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