This isn't an answer exactly, but my advice is don't chase the feel or the hunger supression. Instead only up the dose after 3 weeks of the scale not moving and your reflection in the mirror not improving. It is best as a recomp agent, not a hunger killer or pure weight loss drug. The other two agonists are helping nutrient partitioning and can even INCREASE hunger, metabolism and insulin sensitivity. This means you will feel less and drop weight less than a traditional GLP1. If your diet and training are on point, You are recomping. If you are, then you want to run it as low and slow and long as you can. Not just try to rush it and run into sides.
Done right this is something you see over months not weeks.
I would add fasted cardio, L-Carnitine, Green Tea, Ephedra or SLU before I upped my dose past 2MG.
The only other reason to increase dose (and it is a terrible one) is that the bottle once reconstituted will begin to degrade over months. So if you have a huge 20+mg bottle , you may want to increase the dose to compensate for the lowered potency. This would not be the case currently though.
When you say "its effectiveness" has "gone down slightly" what do you mean? Not suppressing hunger? Not seeing results fast enough?
Are you overweight? Or in shape but looking to cut? What's the goal?