How exactly is one diagnosed with overactive P450?
Is there any evidence that an overactive P450 may lead to decreased testosterone (as P450 is responsible for metabolizing androgens)?
Over active P450 is diagnosed via an FLDP (Functional Liver Detoxification Profile.
I havnt seen any evidence that an overactive P450 would lead to low testosterone - but then I havent even looked into it. If your asking "would this fix my finasteride problem, I would say no - but it may play a part in it". From what I can gather an overactive P450 enzym is quite common and at a guess, I would say about 20% of people probably have it and dont even realize it. Its just one part in the big puzzle.
From what I know, you would not need to take the Grapefruit juice indefinately....you just need to "unclog" your liver by taking it for a month or two and stop eating/drinking things that are hard to digest such as milk.
Also you may need other amino acids such as glutathione, SAMe etc..depending on which detoxification pathways are lagging. This will all show up on an FLDP.
With poor liver function comes lack of bile production so taking ox bile would probably be needed also. But after all, you may not even have these problems, but this gives you an idea of whats required to treat these issues and how complex they can be - especially when from a blood test, your liver looks fine. See your not looking at the state of your liver here (or cell death) your looking at how it functions. The only notable thing on a blood test that will give you a clue as to how it FUNCTIONS is iscolated elevated billirubin - or Gilberts Syndrome. If this shows up it generally means a sluggish liver and you need an FLDP regardless. (things like Uric Acid and others can give clues to liver function though too).
If this still doesnt fix the problem, you need to look into your gut function as gut bugs will constantly produce toxins to the point where your liver will not stand a chance at keeping up with them. A good stool test is needed to find out if you have a gut issue and GOOD stool samples are hard to come by. Your not just looking for Candida here, your looking for stuff like Clostridium , Staph and Strep etc......and a heap more.
PS - This is how i understand it works when doctors explained it to me. There may be peices missing that I dont know.