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LG science Cyclosome, ur thoughts ?

hamdysayed

Well-known member
They r releasing 1 andro with this deliver system that supposed to pass the liver and deliver pure hormone to blood (sounds like injection)
So I tried to search it and I couldn't find any info on that delivery system!
What yalls thought it sounds promising.
VaughnTrue hopefully u can tell us more please
 
its probably just the same thing as VPX used to use.. search liposome and you will learn plenty about it.
 
I don't believe in the "advanced delivery system" the original liquids and the letters had a special delivery that I don't feel lived up to the hype
 
It's called Cyclosome...here's the write up from the website.

LG Sciences is a pioneer in the Bodybuilding and Prohormone industry being one of the first companies to introduce many of the prohormones that have search entered the marketplace over the last decade. Researchers at LG Sciences recently developed a proprietary process called Cyclosome Technology. This one-of-a-kind technology brought to you by the leaders in Prohormones involves the entrapment of hydrophobic prohormones and other Testosterone boosting compounds in the form of water-soluble Prohormone–cyclodextrin (CD) complex in liposomes has been investigated as a new strategy to combine the relative advantages of CDs and liposomes into one system, namely Prohormone-in-CD-in-liposome systems called Cyclosome’s. You can think of all this in terms of a ‘Trojan Horse,’ passing through the liver unharmed and intact. As opposed to being destroyed in the liver like all other hormonal products on the market, past and present. This new Cyclosome technology allows the ‘Trojan Horse’ to deliver prohormones and testosterone boosters to the systemic circulation by the intestinal lymphatic route, circumventing first-pass inactivation in the liver for the very first time. Almost all previous Oral capsules and tablets manufactured to increase testosterone — including Testosterone itself — are involved in the “first pass affect” which renders the active compounds virtually useless.

Cyclosome Technology — the most advanced liposomal delivery technology ever developed for bioavailability is the answer to getting poorly absorbed Testosterone boosting compounds and legal prohormones into the body so they can work ! The pharmaceutical industry has embraced this cutting-edge technology in recent years and now EpiAndro 50 will be one of the first to utilize it in a testosterone booster and anabolic agent.

For Cyclosome preparation, an overall understanding of the interaction between CDs and lipid components of liposomes is necessary for this complex. LG Sciences has developed a Double-loading technique, which is a revolutionary strategy to prohormone release and increase prohormone-loading capacity. The Cyclosome approach can be useful in increasing prohormone solubility and vesicles stability, in controlling the in vivo fate of hydrophobic compounds and in avoiding burst release of prohormones from the vesicles. To obtain a stable Cyclosome, the CDs should have a higher affinity to prohormone molecules compared with liposomal membrane lipids. Cyclosomes prepared by LG’s double-loading technique are the most advanced targeted prohormone delivery system ever developed because they have a fast onset action with prolonged prohormone release process and the significantly enhanced prohormone-loading capacity.
 
It's called Cyclosome...here's the write up from the website.

LG Sciences is a pioneer in the Bodybuilding and Prohormone industry being one of the first companies to introduce many of the prohormones that have search entered the marketplace over the last decade. Researchers at LG Sciences recently developed a proprietary process called Cyclosome Technology. This one-of-a-kind technology brought to you by the leaders in Prohormones involves the entrapment of hydrophobic prohormones and other Testosterone boosting compounds in the form of water-soluble Prohormone–cyclodextrin (CD) complex in liposomes has been investigated as a new strategy to combine the relative advantages of CDs and liposomes into one system, namely Prohormone-in-CD-in-liposome systems called Cyclosome’s. You can think of all this in terms of a ‘Trojan Horse,’ passing through the liver unharmed and intact. As opposed to being destroyed in the liver like all other hormonal products on the market, past and present. This new Cyclosome technology allows the ‘Trojan Horse’ to deliver prohormones and testosterone boosters to the systemic circulation by the intestinal lymphatic route, circumventing first-pass inactivation in the liver for the very first time. Almost all previous Oral capsules and tablets manufactured to increase testosterone — including Testosterone itself — are involved in the “first pass affect” which renders the active compounds virtually useless.

Cyclosome Technology — the most advanced liposomal delivery technology ever developed for bioavailability is the answer to getting poorly absorbed Testosterone boosting compounds and legal prohormones into the body so they can work ! The pharmaceutical industry has embraced this cutting-edge technology in recent years and now EpiAndro 50 will be one of the first to utilize it in a testosterone booster and anabolic agent.

For Cyclosome preparation, an overall understanding of the interaction between CDs and lipid components of liposomes is necessary for this complex. LG Sciences has developed a Double-loading technique, which is a revolutionary strategy to prohormone release and increase prohormone-loading capacity. The Cyclosome approach can be useful in increasing prohormone solubility and vesicles stability, in controlling the in vivo fate of hydrophobic compounds and in avoiding burst release of prohormones from the vesicles. To obtain a stable Cyclosome, the CDs should have a higher affinity to prohormone molecules compared with liposomal membrane lipids. Cyclosomes prepared by LG’s double-loading technique are the most advanced targeted prohormone delivery system ever developed because they have a fast onset action with prolonged prohormone release process and the significantly enhanced prohormone-loading capacity.
Interesting, any sponsored retailer carry it yet ?

That's interesting. With cyclodextrin you are limited to about 25mg compound.
Any change with this?
In for more info what are your thoughts bro?
 
The issue with cyclodextrin complexes IMO is limited dosing capability.

You can't pop 2tabs of ams rde 4ad cause of this.
Does this fix it? That's my question.

It'd be cool if it did.
 
The issue with cyclodextrin complexes IMO is limited dosing capability.

You can't pop 2tabs of ams rde 4ad cause of this.
Does this fix it? That's my question.

It'd be cool if it did.
I'm hoping it is, non liver toxic oral 1 testestorone and dht via epi andro! That's what's up
 
The issue with cyclodextrin complexes IMO is limited dosing capability.

You can't pop 2tabs of ams rde 4ad cause of this.
Does this fix it? That's my question.

It'd be cool if it did.

You mean you'd have to pop one and wait 30 minutes and then pop another one right?
 
Here is the 4-Androstenolone label from the website..

Serving Size: 1 Tablet
Servings Per Container : 60

Propriety Blend
4-Dehydroepiandrosterone (4 androstene-3b-ol,17-one)
Active
50mg

So with this delivery system, does that mean we are now getting the full 50mg?
 
So, they are using cyclodextrin and liposomes to help absorption. All I can say is that our research team looked in to both cyclodextrin and liposomes and neither looked promising enough for us to even test out. Maybe Lg has fixed all these issues with the double encapsulation but I'm not holding my breath. We shall see!
 
Effect on drug bioavailability

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A drug delivery system is expected to deliver the required amount of drug to the targeted site for the necessary period of time, both efficiently and precisely. Different carrier materials are being constantly developed to overcome the undesirable properties of drug molecules.[1] Amongst them, cyclodextrins (CDs) have been found as potential candidates because of their ability to alter physical, chemical and biological properties of guest molecules through the formation of inclusion complexes. CDs were discovered approximately 100 years ago and the first patent o-n CDs and their complexes was registered in 1953.[2] However, their large-scale commercial utilization was prevented mainly due to their high cost and concerns regarding their safety. Recent advancements have resulted in dramatic improvements in CD production, which have lowered their production costs. This has led to the availability of highly purified CDs and CD derivatives which are well suited as pharmaceutical excipients. A lot of work has also been done regarding the safety-assessment of CDs and CD derivatives, which has allayed the fears that were initially raised regarding their safety.

CDs enhance the bioavailability of insoluble drugs by increasing the drug solubility, dissolution and/or drug permeability. CDs increase the permeability of insoluble, hydrophobic drugs by making the drug available at the surface of the biological barrier, e.g., skin, mucosa or the eye cornea, from where it partitions into the membrane without disrupting the lipid layers of the barrier. In such cases it is important to use just enough CD to solubilize the drug in the aqueous vehicle since excess may decrease the drug availability. In the case of water-soluble drugs, CDs increase drug permeability by direct action on mucosal membranes and enhance drug absorption and/or bioavailability.[51]
 
its probably just the same thing as VPX used to use.. search liposome and you will learn plenty about it.

This is completely unique from what VPX uses, and it is the very first time this technology has been used in dietary supplements. Up until now, the only way to utilize this technology was via prescription drugs.

Hi-Tech(which owns LG) has been making a lot of moves lately in the pharmaceutical world. We acquired as pharmaceutical manufacturing plant which included the machinery necessary for the technology. There is literally no other company in our industry that has this technology at their disposal.

That's interesting. With cyclodextrin you are limited to about 25mg compound.
Any change with this?

Yes, this allows for much larger doses to be consumed while simultaneously exceeded basic cyclodextrin dosing.

The issue with cyclodextrin complexes IMO is limited dosing capability.

You can't pop 2tabs of ams rde 4ad cause of this.
Does this fix it? That's my question.

It'd be cool if it did.

Yes, this fixes it. I have not spoken about anabolics since IFN left that game in 2009. I haven't spoken about them because there haven't been any that got me excited enough to use myself. With this change in delivery methods however, I have been very outspoken on them because the science and results in testing is absolutely phenomenal.


So, they are using cyclodextrin and liposomes to help absorption. All I can say is that our research team looked in to both cyclodextrin and liposomes and neither looked promising enough for us to even test out. Maybe Lg has fixed all these issues with the double encapsulation but I'm not holding my breath. We shall see!

This technology is unique from basic cyclodextin/liposome technology. Like I said above, it is the very first time this technology has been available to this industry, and it WILL make a massive difference in the potency and effectiveness of these compounds.



Now, one thing to keep in mind are the target hormones of these compounds. 1-test, test, and boldenone. This means people are going to see gains akin to 1-AD, 4-AD, and Bold200...not things like the OG Dymethazine/Superdrol/Pheraplex which were methyalted steroids. Instead of 25-30lbs in a month, 6-12lbs should be realistic, and it should be very lean and dry gains.
 
Those are pretty big claims. Are these just estimates or do you have testers that have had these results? vaughn true
 
Those are pretty big claims. Are these just estimates or do you have testers that have had these results? vaughn true

what are big claims? that appropriately dosed 1-Testosterone(2x the anabolic power of testosterone), Boldenone(1x the anabolic power of testosterone), and testosterone wont give people 6+lbs of muscle in a month? Do you remember 1-AD and 4-AD and Bold200 when they were on the market?


We test everything we make on users prior to releasing something to the market, no other way to truly know if something works or not.
 
what are big claims? that appropriately dosed 1-Testosterone(2x the anabolic power of testosterone), Boldenone(1x the anabolic power of testosterone), and testosterone wont give people 6+lbs of muscle in a month? Do you remember 1-AD and 4-AD and Bold200 when they were on the market?


We test everything we make on users prior to releasing something to the market, no other way to truly know if something works or not.

Comparing these to 1,4 ad is a big claim. That's awesome if you guys have beta tested it and these results have been achieved by multiple testers, looking forward to seeing everyone's results from these new products!
 
Comparing these to 1,4 ad is a big claim. That's awesome if you guys have beta tested it and these results have been achieved by multiple testers, looking forward to seeing everyone's results from these new products!

I'm not sure I'm understanding why this is a bold claim.

our 1-andro converts to 1-testosterone, same as 1-ad did.

our 4-andro converts to testosterone, same as 4-ad did.

our bold product(s) convert to boldenone, same as Bold200 did.
 
I'm not a fan of dehydro-17hydroxy-progesterone

But the rest are interesting. How's the price compared to say ams 4-ad rde?
 
I'm not a fan of dehydro-17hydroxy-progesterone

But the rest are interesting. How's the price compared to say ams 4-ad rde?

can you link me or post up the formula on this product? I want to make sure I'm comparing apples to apples here
 
I'm not sure I'm understanding why this is a bold claim.

our 1-andro converts to 1-testosterone, same as 1-ad did.

our 4-andro converts to testosterone, same as 4-ad did.

our bold product(s) convert to boldenone, same as Bold200 did.

But it's a 2 step conversion instead of 1,4 ad's 1 step conversion into the target hormones. That extra step significantly weakens the compound. That's awesome if you made a 2 step conversion hormone as strong as a 1 step conversion, it should be very impressive.
 
Now, one thing to keep in mind are the target hormones of these compounds. 1-test, test, and boldenone. This means people are going to see gains akin to 1-AD, 4-AD, and Bold200...

Maybe 1,4 bold because that was very mild. I hope you aren't talking about the original 1AD and 4AD though, because that's huge stretch.
 
Maybe 1,4 bold because that was very mild. I hope you aren't talking about the original 1AD and 4AD though, because that's huge stretch.

That is exactly what he was referring to.
 
That is exactly what he was referring to.

you guys seem to be remembering very different gains off 1-AD/4-AD than the rest of the world. They were great products, but didn't put on 20lbs/month for users, not even as insane doses.
 
you guys seem to be remembering very different gains off 1-AD/4-AD than the rest of the world. They were great products, but didn't put on 20lbs/month for users, not even as insane doses.

I'm with you on the weight gain. They were good, but most logs only show ~8-12 lbs stacked
 
you guys seem to be remembering very different gains off 1-AD/4-AD than the rest of the world. They were great products, but didn't put on 20lbs/month for users, not even as insane doses.
You are correct

But not sure about others, but even though I inject, I still use these products. Rhook can account for that.
I have a bottle of 4-ad rde on my counter right now, an a vial of test prop in my stash.
They are different but each has a place.
 
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