Pax
Registered User
If I understand correctly, M1-P is progestin based and utlizes a key ingredient called Megestrol Acetate. I'm by no means claiming to be a chemist or anything, but they are claiming lots of research about their product, and the research articles they cite to on the 1fast400.com website product write-up appear to promote the idea that this product can be used like oxandrolone (anavar) to prevent muscle wasting.
Here is what I've read:
"Oster enrolled 100 patients in a double-blind placebo-controlled trial of megestrol acetate (MA) (800 mg/day). MA recipients increased their daily calorific intake by 608 calories, versus an increase of 134 in the placebo group. People treated with MA had a mean body weight increase of 3.86 kg, compared with 0.46 kg decrease in the placebo group, and gained 3.68 kg in fat compared with a 0.28 kg loss. No statistically significant differences in body water, lean mass or survival were observed between the groups.
Johnston enrolled 89 people with CD4 counts below 200 and a weight loss of greater than 5% in a placebo-controlled study of megestrol acetate (320 mg/day for two weeks each month). After 6 months, treated people had a significant increase in tricipital skinfold thickness and quality of life, but other changes in nutritional parameters were not significant.
Tierney randomized people with AIDS with a greater than or equal to 10% weight loss to receive a daily dose of 100, 400 or 800 mg of megestrol acetate or placebo during a three month double-blind trial. 19/21 evaluable treated subjects gained weight (1.5 - 29 lbs), while those randomized to receive placebo continued to lose weight. The 2 treated subjects who lost weight had developed an oesophageal ulcer and histoplasmosis, respectively. Megestrol acetate was associated with significant weight gain with a linear dose response relationship. An increase in both lean body mass and body fat was detected using bioelectrical impedance analysis. Weight gain was associated with an increase in appetite and food intake. No improvements in CD3, CD4, CD8 counts or skin reactivity was seen. While Karnofsky scores did not change, improvement in perceived quality of life was associated with weight gain.
Graham enrolled 10 patients with HIV-related wasting in a pharmacokinetic evaluation study of a new suspension formulation of megestrol acetate 40 mg/ml. All patients received a single oral dose of 800 mg/day for 21 days. All patients reported an increase in appetite and 8/10 patients gained weight at three weeks.
Testosterone and steroids
Research into testosterone plus exercise are summarised under the sub-heading ‘Resistance exercise’ below.
Grinspoon randomised 51 HIV-positive men with low testosterone levels to either 300mg of intramuscular testosterone enanthate injected every 3 weeks for 6 months, or placebo. The testosterone group gained fat-free mass (-0.6kg and 2.0kg), lean body mass (no change to 1.9kg) and muscle mass (-0.8 ad 2.4kg). "
So If I've read about this all correctly, M1-P simply increases appetite and leads to hight caloric consumption, thereby promoting a gain in mean body weight for its users. However, this appears to be mass attributable to fat and not lean body mass.
Am I way off here....?
Here is what I've read:
"Oster enrolled 100 patients in a double-blind placebo-controlled trial of megestrol acetate (MA) (800 mg/day). MA recipients increased their daily calorific intake by 608 calories, versus an increase of 134 in the placebo group. People treated with MA had a mean body weight increase of 3.86 kg, compared with 0.46 kg decrease in the placebo group, and gained 3.68 kg in fat compared with a 0.28 kg loss. No statistically significant differences in body water, lean mass or survival were observed between the groups.
Johnston enrolled 89 people with CD4 counts below 200 and a weight loss of greater than 5% in a placebo-controlled study of megestrol acetate (320 mg/day for two weeks each month). After 6 months, treated people had a significant increase in tricipital skinfold thickness and quality of life, but other changes in nutritional parameters were not significant.
Tierney randomized people with AIDS with a greater than or equal to 10% weight loss to receive a daily dose of 100, 400 or 800 mg of megestrol acetate or placebo during a three month double-blind trial. 19/21 evaluable treated subjects gained weight (1.5 - 29 lbs), while those randomized to receive placebo continued to lose weight. The 2 treated subjects who lost weight had developed an oesophageal ulcer and histoplasmosis, respectively. Megestrol acetate was associated with significant weight gain with a linear dose response relationship. An increase in both lean body mass and body fat was detected using bioelectrical impedance analysis. Weight gain was associated with an increase in appetite and food intake. No improvements in CD3, CD4, CD8 counts or skin reactivity was seen. While Karnofsky scores did not change, improvement in perceived quality of life was associated with weight gain.
Graham enrolled 10 patients with HIV-related wasting in a pharmacokinetic evaluation study of a new suspension formulation of megestrol acetate 40 mg/ml. All patients received a single oral dose of 800 mg/day for 21 days. All patients reported an increase in appetite and 8/10 patients gained weight at three weeks.
Testosterone and steroids
Research into testosterone plus exercise are summarised under the sub-heading ‘Resistance exercise’ below.
Grinspoon randomised 51 HIV-positive men with low testosterone levels to either 300mg of intramuscular testosterone enanthate injected every 3 weeks for 6 months, or placebo. The testosterone group gained fat-free mass (-0.6kg and 2.0kg), lean body mass (no change to 1.9kg) and muscle mass (-0.8 ad 2.4kg). "
So If I've read about this all correctly, M1-P simply increases appetite and leads to hight caloric consumption, thereby promoting a gain in mean body weight for its users. However, this appears to be mass attributable to fat and not lean body mass.
Am I way off here....?
