Anyone have any good trustworthy references on cardarine? I’m interested in starting some supplementation other than staples at some point soon so I wanna start researching a few things.
Edit: also, is that the supp that has had some (bladder?) cancer “risk” (i think I remember it being extremely small or even questionable if it was real) associated with it?
Double edit:
Answered my own Q:
“Warnings/Precautions (for pioglitazone, a PPAR gamma agonist used in DM) (note: cardarine is a PPAR delta/beta agonist)
Concerns related to adverse effects:
• Bladder cancer: An FDA review concluded that although clinical trial data are inconsistent regarding the risk of bladder cancer in patients exposed to pioglitazone, there is still the potential for an increased risk and package labeling has been updated to reflect this. Avoid use of pioglitazone in patients with active bladder cancer and consider risks versus benefits prior to initiating therapy in patients with a history of bladder cancer.
• edema...
• fractures....
• heart failure...
• hematologic effects ...
• hepatic effects...
• hypoglycemia
• macular edema
• weight gain: Dose-related weight gain observed with use; mechanism unknown but likely associated with fluid retention and fat accumulation”
Interestingly, the bladder cancer warning isnt present when I look up rosiglitazone, which is also in the thiazolidinedione class.
Additionally:
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those doses are way higher than what ive seen people using & it also sounds like duration of supplementation played a big role in the observed carcinogenicity.