Info on AIs

[CatSnake]

I thought I'd add a thread similar to the SERM thread with some info on AI's, based off their clinical data...

In general, one can expect an AI to increase testosterone, FSH, LH, and decreasing IGF1, estradiol, SHBG

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Side note:

SERM Thread:

http://anabolicminds.com/forum/post-cycle-therapy/288103-info-serms.html

HCG Thread:

http://anabolicminds.com/forum/post-cycle-therapy/297449-info-hcg.html#post5870442

 

[CatSnake]

Aromasin (exemestane)

25 mg/day increase testosterone 60% and decreases estradiol 38% in 10 days:

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Aromasin acts a pro-hormone?

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[CatSnake]

Arimidex (anastrozole)

1 mg/day increased testosterone from 343 to 572 and decreased estradiol from 26 to 17 in 12 weeks:

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(^interestingly enough, the group with 1 mg 2x per week was nearly as effective as the group with 1 mg/day)



1 mg/day increased testosterone 58% and decreased estradiol 48% and IGF1 18% in 10 weeks:

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[CatSnake]

Femara (letrozole)

2.5 mg/wk decreased estradiol from 123 to 57 and increased testosterone from 5.9 to 19.6, LH from 4.4 to 11.1 and FSH from 4.8 to 12.1 in 6 weeks:

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5 mg/wk decreased estradiol by 53 pmol, increased testosterone 12.8 nmol, and decreased 7 kg/bodyweight in 6 months:

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^however, letro is notorious for crashing E2 levels to undetectable levels, so there's that concern...

 

[Sdog77]

Sub'ed for great info. Thanks!

 

[livestrong82]

Sub

 

[CatSnake]

and here's a study on Arimidex for gyno:

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interestingly enough, the only AI I'm aware of that has been studied clinically for this.....

 

[Stalpeth]

Thanks for posting trying to learn all I can

 

[CatSnake]

Update:

One thing to add, is that dosing an AI at the same time as an injection might not be a good idea. it takes a while for the cyp/enanthate/prop to get absorbed in the body, and a tad longer before the body recognizes the high testosterone levels and begins aromatization into estrogen/estradiol....

personally, I found taking arimidex when I took an injection to result in low E2 symptoms the next day. however, taking the arimidex 4-12 hours after the injection has completely mitigated that side effect.


"For the 100 mg group, the average Cmax peaked above 1,200 ng/dL 24 hours after the last dose and declined to slightly above 600 ng/dL after 1 week." (testosterone enanthate)

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Various doses of testosterone, and ensuing E2 levels, etc

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"Anastrozole was rapidly absorbed orally (time to reach maximum concentration, 1 h) with a slow apparent clearance of 1.54 liters/h and a terminal half-life of 46.8 h."

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