You have done your homework. Good to see. Yes, the DES can definetly lock onto receptors that aren't recognized by the other types. This is one reason it works well when pinned Preworkout. IGF as.you know is has both paracrine and autocrine subtypes. The systemic IGF created when HGH is broken down by the liver travels through the bloodstream and can bind to wherever receptors are located. By training we hope to guide preferentially to sensjtized muscle cells. The problem with systemic is,the intestines have a plethora of IGF receptors which is why I think doses of Lr3 should be kept to a minmum. With such a long life it has plenty of time to search for receptors and it doesn't take much to saturate muscle tissue. The DES mimics locally produced IGF and can access more receptors. It's short life is a blessing because it will be used by the muscle you injected it into and will spend the majority of it's life right where you want it. That's the theory anyway. It is also much more resistant to binding proteins because of the,aforementioned truncation. You might not get as much systemic growth but if that includes organs then there much better ways of. Promoting whole body anabolism.
Oh yes, brother. I'm a big proponent of doing your own research. I also have preexisting chemistry knowledge from other forays, so understanding this stuff comes a little more easily. Some of the questions I post sit for awhile since I try to rule out the obvious first. I believe in always pushing others to do the same. Knowledge is both power and safety.
Thanks for taking the time with your in-depth replies. I have sampled what seems to be this regular IGF both pre and post workout. I did the pre times without any pre-workout or anything, and the pumps were noticeably better. My girlfriend said that my biceps matched my triceps for once lol (my biceps don't like to keep up with my tris.)
Next time I'll try some DES just to see the differences and post back since this seems to be the only thread on the internet involving IGF which is neither DES or LR3.
I must also agree with your distaste for LR3. Same thing goes for true CJC-1295 (with the DAC). Many bros love the results but I'm just over here like, "but, man, the human body isn't designed to have those growth factors floating around everywhere at static high levels all the time." It's my opinion that we are playing with enough fire shooting a quick variant directly into the muscle.
Since this is basically just us talking and it is IGF related, what is your view on the pegylated MGF. I don't see as much of an issue with that because if my research is correct it shouldn't have any affinity for the standard IGF receptors and would travel systemically searching solely for damaged tissue. Am I completely off base on that?