Igf-1?

[dcoen21]

Any supplements out there with a focus on increasing the igf-1 pathway?

 

[sdplissken]

MSM. It amplifies IGF-1 signalling and in the same time attenuates cortisol effect on muscle cells. It has also many other health benefits. It is a staple for me. 3 grams a day.

 

[Wallet55]

MSM. It amplifies IGF-1 signalling and in the same time attenuates cortisol effect on muscle cells. It has also many other health benefits. It is a staple for me. 3 grams a day.

Im curious, do you have a study on this?

 

[cheftepesh1]

Mk677 is supposed to work great on IGF-1 and GH levels.

 

[cheftepesh1]

Mk677 is supposed to work great on IGF-1 and GH levels.

 

[sdplissken]

Im curious, do you have a study on this?

MSM Enhances GH Signaling via the Jak2/STAT5b Pathway in Osteoblast-Like Cells and Osteoblast Differentiation through the Activation of STAT5b in MSCs

Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound with well-known anti-oxidant properties and anti-inflammatory activities. But, its effects on bone are unknown. Growth hormone (GH) is regulator of bone growth and bone metabolism. GH ...

www.ncbi.nlm.nih.gov

The same pathway seems to exist in muscle cells too.

Regulation of murine skeletal muscle growth by STAT5B is age- and sex-specific - Skeletal Muscle

Background Sexually dimorphic growth has been attributed to the growth hormone (GH)/insulin-like growth factor 1 (IGF1) axis, particularly GH-induced activation of the intracellular signal transducer and activator of transcription 5B (STAT5B), because deletion of STAT5B reduces body mass and the...

skeletalmusclejournal.biomedcentral.com

 

[ironkill]

MSM, growth hormone and IGF-1 | Stronger bones, stronger muscles?

According to a handful of human studies, MSM supplementation accelerates muscle recovery after intense exercise. That may be because MSM reduces the effect of cortisol, we wrote a few days ago. Another possibility is that MSM enhances the action of growth hormone and IGF-1 in muscle tissue, we...

www.ergo-log.com

MSM, a muscle enhancer that sabotages cancer cells

According to in vitro studies, MSM blocks the demolition hormone cortisol in muscle cells while increasing the action of IGF-1 and growth hormone. With such beautiful muscle strengthening effects, we get worried that MSM may also promote cancer. However, that fear is unjustified, fundamental...

www.ergo-log.com

 

[Wallet55]

MSM Enhances GH Signaling via the Jak2/STAT5b Pathway in Osteoblast-Like Cells and Osteoblast Differentiation through the Activation of STAT5b in MSCs

Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound with well-known anti-oxidant properties and anti-inflammatory activities. But, its effects on bone are unknown. Growth hormone (GH) is regulator of bone growth and bone metabolism. GH ...

www.ncbi.nlm.nih.gov

The same pathway seems to exist in muscle cells too.

Regulation of murine skeletal muscle growth by STAT5B is age- and sex-specific - Skeletal Muscle

Background Sexually dimorphic growth has been attributed to the growth hormone (GH)/insulin-like growth factor 1 (IGF1) axis, particularly GH-induced activation of the intracellular signal transducer and activator of transcription 5B (STAT5B), because deletion of STAT5B reduces body mass and the...

skeletalmusclejournal.biomedcentral.com

What kind of dosage should this be useful at? I was planning on taking 3g/day.

 

[dcoen21]

I take 3 grams of msm as it is now wonder if I should take more as the studies reference up to nine grams a day.

 

[sdplissken]

What kind of dosage should this be useful at? I was planning on taking 3g/day.

1 gr tid is the way to go. On 3 grams a day after a while you get better joints, ligaments, skin, hair, recovery, a gh like effect. It has many other health benefits like anticancer activity and it's dirt cheap.

 

[LeanEngineer]

1 gr tid is the way to go. On 3 grams a day after a while you get better joints, ligaments, skin, hair, recovery, a gh like effect. It has many other health benefits like anticancer activity and it's dirt cheap.

Seems like a laundry list of benefits. Sounds like it would be worth running if it's cheap to try it out.